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Rheumatology

Case Studies

Lupus induced by shingles vaccine

The first report of lupus induced by the recombinant zoster vaccine. Given the ongoing widespread vaccination campaigns, clinicians need to be aware of this possible adverse reaction.

Diagnostic dilemma: neuropsychiatric lupus or WNV encephalitis?

Neuropsychiatric SLE and infections, such as West Nile encephalitis, can be difficult to differentiate, as demonstrated by these cases. This challenge is vital to overcome due to the opposing management strategies.

Kidney involvement in VEXAS syndrome

VEXAS syndrome is a recently identified genetic autoinflammatory disorder. This case highlights its under-recognized renal manifestations and underscores the need for heightened clinical suspicion and earlier intervention.

Takayasu arteritis complicated by SAPHO syndrome

Two patients presenting with anterior chest pain were diagnosed with Takayasu arteritis co-existing with SAPHO syndrome, a rare inflammatory osteoarticular disorder. Their symptoms improved with glucocorticoids and biologic agents.

Atypical manifestation of giant cell arteritis

The presence of a non-healing tongue ulcer indicated end-organ damage from GCA and prompted suspicion of the condition even in the absence of imaging or biopsy evidence. The patient responded to treatment, confirming the diagnosis.

Heterotopic ossification after wrist replacement

The first reported case of heterotopic ossification following total wrist arthroplasty. Revision surgery was performed to remove ossifications and no further signs have been reported, but the patient's range of motion remains reduced.

Successful treatment of stroke due to Takayasu arteritis

Mechanical thrombectomy and stenting were used to manage large vessel occlusion stroke in a patient with Takayasu arteritis, without any short- or long-term complications. This approach could be an effective option in these patients.

Ulcerative cutaneous sarcoidosis: a diagnostic challenge

Diagnosing cutaneous sarcoidosis can be challenging due to its diverse skin manifestations, which can mimic other conditions. In this case, the patient presented with chronic leg ulcers.

Association of IgA vasculitis with rare leukemia

This first report of IgA vasculitis associated with chronic myelomonocytic leukemia highlights the need for awareness of underlying hematologic malignancies in patients presenting with unexplained vasculitis.

Novel association of chilblains with inflammatory arthritis

Three patients with inflammatory arthritis had concomitant chilblains and bone marrow edema as revealed by MRI. Could this trifecta represent a new clinical phenotype of seronegative spondyloarthropathies?

Early atypical MRI findings in Neuro-Behçet's disease

In pediatric patients with unexplained neurological symptoms and MRI findings of lateral ventricular lesions or brainstem-thalamus-basal ganglia abnormalities, monitor closely for BD signs.

SLE presenting with bilateral retinal vasculitis

A unique case of bilateral retinal vasculitis as the initial manifestation of systemic lupus erythematosus. Recognizing the possibility of such atypical presentations allows clinicians to maintain a high index of suspicion for SLE.

Digital vasculitis as rare presentation of anti-synthetase syndrome

The patient presented with digital vasculitis, rapidly evolving interstitial lung disease, sub-clinical myositis, and arthritis of the hands with no prior history of Raynaud’s phenomenon. What antibodies would you test to determine the final diagnosis?

Tuberculosis of the elbow joint

Elbow tuberculosis is a rare manifestation of TB, with symptoms often mimicking diseases such as rheumatoid or septic arthritis. Surgical intervention can greatly benefit diagnosis, but is not always necessary for successful treatment.

GCA as a potential cause of aseptic meningitis?

A patient diagnosed with aseptic meningitis developed a right temporal headache with scalp tenderness, and imaging results were consistent with giant cell arteritis. Could the GCA have caused the aseptic meningitis?

Acute pancreatitis as presenting feature of SLE

Gastrointestinal involvement is common in systemic lupus erythematosus but acute pancreatitis as an initial manifestation is extremely rare. The patient's abdominal symptoms resolved after corticosteroid and cyclophosphamide therapy.

Uncommon type of vasculitis

Isolated celiac artery vasculitis is extremely rare, but it should be considered in the differential diagnosis of unexplained abdominal pain, particularly when imaging reveals vascular abnormalities.

Successful treatment of juvenile dermatomyositis

The JAK inhibitor tofacitinib proved effective in treating a 7-year-old with anti-MDA5 antibody-positive juvenile dermatomyositis complicated by refractory interstitial lung disease.

Rare complication of Kawasaki disease

Kawasaki disease rarely causes arrhythmias, but this infant was diagnosed with supraventricular tachycardia, which resolved after combination treatment with intravenous immunoglobulin and steroids.

How to diagnose rheumatoid meningitis

RM is a rare cause of chronic meningitis. Varied clinical manifestations and the absence of recognized criteria make diagnosis difficult, but this case illustrates what you need to look for.