Rheumatology

Recent advances in understanding the pathogenesis of juvenile-onset systemic lupus erythematosus has prompted the development of screening tools, molecular predictors, and new treatments.

A case illustrating a rare but important association between Behçet disease and Hodgkin lymphoma, possibly mediated by immune dysregulation and chronic immunosuppression.

A comprehensive review on hypoparathyroidism, offering an updated and holistic perspective on its management to support the delivery of effective and individualized care across the spectrum of disease severity.

Deaths due to hemophagocytic lymphohistiocytosis in Europe have almost doubled in a decade, highlighting major gaps in awareness, diagnosis, and reporting.

Understand the pros and cons of the available imaging modalities for diagnosing axial and peripheral forms of spondyloarthritis, and discover the role that artificial intelligence may play in diagnosis and management. 

Three cases of new-onset LVV that developed after COVID-19. All patients had elevated anti-ACE2 antibodies that normalized after clinical remission. Do these antibodies have a role in the pathogenesis of post-COVID-19 vasculitis?

Transcutaneous auricular vagus nerve stimulation does not significantly improve hand pain relative to sham stimulation in people with erosive hand osteoarthritis, but may benefit certain subgroups.

The STAMP trial has shown similar improvements in psoriatic arthritis clinical outcomes with intensive treat-to-target strategies with additional secukinumab and a standard step-up treat-to-target approach with methotrexate.

How can FDG-PET be used to diagnose and monitor disease activity in different forms of large-vessel vasculitis? And what improvements are needed to make it easier to incorporate PET imaging into a clinical workflow?

Many patients with antiphospholipid syndrome have uncontrolled cardiovascular risk factors, with primary APS patients showing particularly poor target attainment.

Ongoing research is transforming the understanding of juvenile dermatomyositis, and revealing new therapeutic and biomarker opportunities. These advances offer the potential to improve outcomes and achieve durable remission.

This case highlights that extreme reactive thrombocytosis may be part of the initial presentation of microscopic polyangiitis, potentially serving as an early diagnostic clue in the context of systemic inflammation. 

Allogeneic chimeric antigen receptor therapy with natural killer cells shows promise for treating people with refractory or relapsed systemic lupus erythematosus.

People with rheumatic diseases have an increased risk for myocardial infarction, underscoring the need for early risk stratification, integrated cardio-rheumatologic care, and precision-based therapeutic strategies.

Pregnancies in women with systemic sclerosis are associated with higher rates of adverse pregnancy outcomes, severe postpartum hemorrhage, and maternal disease worsening.

The first case of VEXAS syndrome with features of Sjögren disease, including chronic oral sicca, high-titer SSA antibodies, a positive rheumatoid factor, and lymphopenia.

Acute complications requiring ICU management remain a major cause of morbidity and mortality in rheumatic diseases. This disease-specific overview of ICU risks, complications, and outcomes provides a primer for clinicians.

Dual X-ray absorptiometry is a valuable tool for assessing bone density and fracture risk. But it is essential to be familiar with the guidelines, limitations, and pitfalls to optimize the interpretation of results and guide clinical decisions.

Fulminant autoimmune myocarditis was the initial manifestation of Sjögren disease, complicated by electrical storm and cardiogenic shock. Prompt initiation of corticosteroids resulted in rapid cardiac recover and successful VA-ECMO weaning.

The FcRn blocker nipocalimab significantly improves clinical disease activity in people with moderate-to-severe Sjögren disease and could be a promising approach for these patients.