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Rheumatology

Editor's Choice

Baricitinib shows promise for polymyalgia rheumatica

Treatment with the JAK inhibitor baricitinib for 12 weeks results in low disease activity for individuals with a recent diagnosis of polymyalgia rheumatica compared with placebo.

JAK inhibition promising for refractory Behçet’s disease

A patient with Behçet's disease refractory to standard therapies, and complicated by uveitis and axial spondyloarthritis, responded to treatment with upadacitinib, pointing to a role for JAK inhibition in this setting.

Long-term trial data continue to support bimekizumab for axSpA

Extended follow-up of the BE MOBILE 1 and 2 trials shows bimekizumab is well tolerated and efficacious in individuals with axial spondyloarthritis for up to 2 years after initiation.

CAR T-cell therapy for autoimmune diseases

CAR T-cell therapy has revolutionized the treatment of various hematologic malignancies. But could it also have a role in treating refractory autoimmune diseases? What do findings from case reports and early clinical trials indicate?

No need to avoid TNF inhibitors in RA-associated ILD

TNF inhibitors do not appear to increase the risk for respiratory hospitalization or death in people with interstitial lung disease associated with rheumatoid arthritis.

ALS in a patient with CLL and drug-related SLR

A man with a skin rash and left leg weakness was diagnosed with sarcoid-like reaction due to treatment for chronic lymphocytic leukemia, and ultimately also amyotrophic lateral sclerosis when the motor symptoms progressed.

Unconventional imaging methods in psoriatic arthritis

Novel imaging modalities that enable both structural and molecular characterization hold great promise for improving the understanding of psoriatic arthritis and and advancing toward personalized medicine.

Infrequent zoledronate fights postmenopausal vertebral fracture risk

Women with a healthy bone mineral density may benefit from occasional infusions of zoledronate between age 50 and 60 years.

Allogeneic HSCT promising for treating lung disease in JIA

Lung disease associated with refractory systemic juvenile idiopathic arthritis appears to be improved by allogeneic hematopoietic stem cell transplantation.

Spondyloarthritis and cancer risk

The risk for malignancy in people with spondyloarthritis remains a controversial issue. What is the current evidence for the impact of the disease and its treatment with biologic and targeted synthetic DMARDs?

Rare initial manifestation of SLE

A patient with systemic lupus erythematosus was initially diagnosed with Evans syndrome, an autoimmune hematologic disorder. The case was further complicated by the co-existence of Hashimoto’s thyroiditis and pernicious anemia.

Polyarteritis nodosa presenting with severe GI bleeding

Although gastrointestinal involvement is known in polyarteritis nodosa, severe gastrointestinal bleeding due to gastric ulceration is relatively uncommon. This case sheds light on this rare complication.

Colchicine prophylaxis reduces CV events in patients with gout

  • 09-01-2025
  • Gout
  • News

Taking colchicine prophylaxis at the time of initiating urate-lowering therapy for gout flare could reduce the risk for cardiovascular events.

Use of platelet-rich plasma in rheumatic diseases

Platelet-rich plasma is a promising therapeutic agent for managing various rheumatic and musculoskeletal disorders. Learn about the evidence supporting its use for pain relief, functional improvement, and more.

Atypical Kawasaki disease in a 2-month-old boy

A case underscoring the importance of considering Kawasaki disease in infants presenting with prolonged, antibiotic-resistant fever, even though the condition is uncommon in children younger than 6 months.

Are heated mittens useful in osteoarthritis?

Wearing heated mittens for at last 15 minutes a day for 6 weeks does not significantly improve physical hand function in people with hand osteoarthritis compared with standard mittens.

Urate lowering to target feasible in patients with gout and CKD

Urate-lowering therapy to below 6 mg/dL in people with gout and chronic kidney disease does not increase the risks for kidney disease progressing to severe or end-stage.

Fractures in adulthood linked to later fracture risk

Any fracture in adulthood may be associated with an increased risk for future fracture, regardless of the age at which the first fracture occurs.

Recommendations for the use of generative AI in medicine

This position statement from the SGIM serves as a guide for exploring how generative AI may benefit medical practice, focusing on clinical decision-making, health systems optimization, and the patient–physician relationship.

Anastrozole boosts growth potential in children with CAH

Anastrozole could help optimize growth for children with congenital adrenal hyperplasia and advanced bone age.