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Internal Medicine Rheumatology

Rheumatology

Recommendations for the use of generative AI in medicine

This position statement from the SGIM serves as a guide for exploring how generative AI may benefit medical practice, focusing on clinical decision-making, health systems optimization, and the patient–physician relationship.

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Editor's Choice

Anastrozole boosts growth potential in children with CAH

Anastrozole could help optimize growth for children with congenital adrenal hyperplasia and advanced bone age.

Better pain relief with total hip replacement for hip osteoarthritis

Total hip replacement for severe hip osteoarthritis significantly improves pain and function in adults aged 50 years or older compared with resistance training.

Semaglutide shows promise for obesity-related osteoarthritis

STEP 9 trial results suggest that treatment with semaglutide may significantly reduce both bodyweight and knee pain in people with obesity and knee osteoarthritis.

Romosozumab for the treatment of osteoporosis

The monoclonal antibody romosozumab has a transient but robust bone anabolic effect. Find out what is currently known about its clinical efficacy and safety for the treatment of primary and secondary osteoporosis.

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Case Studies

Triple vessel spontaneous CAD in polyarteritis nodosa

Triple-vessel spontaneous coronary artery dissection and polyarteritis nodosa are both extremely rare. Their coexistence is exceptional and presents unique diagnostic and therapeutic challenges.

Combined treatment for PML

Progressive multifocal leukoencephalopathy is an often fatal CNS disease caused by JC virus infection. In this case, low-dose, long-term immunoglobulin plus mirtazapine resulted in a controlled inflammatory reaction.

Lumbar sympathetic block to treat CRPS in a toddler

After non-invasive measures failed, a lumbar sympathetic block performed with extreme caution alleviated complex regional pain syndrome in this 18-month-old.

Current Reviews

Therapeutic potential of exosomes derived from mesenchymal stem cells for treatment of systemic lupus erythematosus

Autoimmune diseases are caused by an imbalance in the immune system, producing autoantibodies that cause inflammation leading to tissue damage and organ dysfunction. Systemic Lupus Erythematosus (SLE) is one of the most common autoimmune diseases …

Efficacy and safety of current therapies for difficult-to-treat rheumatoid arthritis: a systematic review and network meta-analysis

Rheumatoid arthritis (RA) is a common and chronic inflammatory autoimmune disease characterized by destructive, chronic, debilitating arthritis [ 1 ]. According to the European Alliance of Associations for Rheumatology (EULAR) RA management …

Previous lumbar spine fusion increases the risk of dislocation following total hip arthroplasty in patients with hip-spine syndrome: a systematic review and meta-analysis

  • Open Access
  • Hip-TEP
  • Systematic Review

Degenerative hip and spine disorders are becoming more prevalent in the aging population, especially with the global increase of life expectancy. Among adults above the age of 60, 19–47% are estimated to have spinal stenosis [ 1 ]. Furthermore, hip …

Mitochondrial transplantation: a promising strategy for treating degenerative joint diseases

The prevalence of age-related degenerative joint diseases, particularly intervertebral disc degeneration and osteoarthritis, is increasing, thereby posing significant challenges for the elderly population. Mitochondrial dysfunction is a critical …

Further Reading

Therapeutic potential of exosomes derived from mesenchymal stem cells for treatment of systemic lupus erythematosus

Autoimmune diseases are caused by an imbalance in the immune system, producing autoantibodies that cause inflammation leading to tissue damage and organ dysfunction. Systemic Lupus Erythematosus (SLE) is one of the most common autoimmune diseases …

Effects of exogenous deoxyribonuclease I in collagen antibody-induced arthritis

Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease affecting around 1% of the population and its etiopathogenesis is still unknown [ 1 ]. The lack of knowledge about the real causes of RA leads to the absence of causal …

Facilitators and challenges of implementing a digital patient education programme for rheumatoid arthritis into clinical practice

Telehealth and digital interventions are increasingly used in rheumatology and have the potential to improve patient care by offering more efficient access to healthcare. However, the adoption of tele-health interventions into clinical practice is …

Policies in Canada fail to address disparities in access to person-centred osteoarthritis care: a content analysis

Osteoarthritis (OA) is defined as a primarily degenerative, sometimes inflammatory disease characterised by stiffness, inflammation, and physical and psychological impairments [ 1 ]. The Global Burden of Disease Study reported that prevalent cases …