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AI to predict treatment response in RA and SpA

Artificial intelligence technologies show substantial potential in predicting treatment responses in rheumatoid arthritis and spondyloarthritis. However, challenges such as methodological variability, data integration, and external validation remain.

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Editor's Choice

Disease-modifying therapies in lupus nephritis

Of the current treatments for lupus nephritis, how many can be classed as disease modifying according to recently proposed criteria? And what are the challenges and considerations for future studies?

Upadacitinib may offer a glucocorticoid-sparing option for GCA

Upadacitinib once daily, combined with glucocorticoid taper, may be more effective than placebo for inducing sustained remission in patients with giant cell arteritis.

Early atypical MRI findings in Neuro-Behçet's disease

In pediatric patients with unexplained neurological symptoms and MRI findings of lateral ventricular lesions or brainstem-thalamus-basal ganglia abnormalities, monitor closely for BD signs.

Gout and psoriatic disease: an evolving conundrum

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  • Gout
  • Review

The overlap between gout and psoriatic disease has been known since the 1980s. But what are the key mechanisms underlying this association, how does it influence management, and should "Psout" be considered a novel disease?

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Episode 17: Challenges of developing DMOADs

Why are disease-modifying treatments for osteoarthritis such a difficult proposition?

Despite multiple attempts, no DMOAD is yet approved for clinical use. Prof. Ali Mobasheri takes us through the main challenges, the work being done to make these so-called utopia drugs a reality, and discusses other advances that offer hope in the meantime.

Prof. Ali Mobasheri
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Podcast

Case Studies

Early atypical MRI findings in Neuro-Behçet's disease

In pediatric patients with unexplained neurological symptoms and MRI findings of lateral ventricular lesions or brainstem-thalamus-basal ganglia abnormalities, monitor closely for BD signs.

SLE presenting with bilateral retinal vasculitis

A unique case of bilateral retinal vasculitis as the initial manifestation of systemic lupus erythematosus. Recognizing the possibility of such atypical presentations allows clinicians to maintain a high index of suspicion for SLE.

Digital vasculitis as rare presentation of anti-synthetase syndrome

The patient presented with digital vasculitis, rapidly evolving interstitial lung disease, sub-clinical myositis, and arthritis of the hands with no prior history of Raynaud’s phenomenon. What antibodies would you test to determine the final diagnosis?

Keynote webinar | Spotlight on advances in lupus

  • Live
  • Webinar | 27-05-2025 | 18:00 (CEST)

Systemic lupus erythematosus is a severe autoimmune disease that can cause damage to almost every system of the body. Join this session to learn more about novel biomarkers for diagnosis and monitoring and familiarise yourself with current and emerging targeted therapies.

Join us live: Tuesday 27th May, 18:00-19:15 (CEST)

Prof. Edward Vital
Prof. Ronald F. van Vollenhoven
Developed by: Springer Medicine
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Webinar

Current Reviews

Deciphering the role of cell signaling pathways in gout pathogenesis and the therapeutic potential of phytoconstituents in their modulation

Gout is an acute and recurrent inflammatory arthritis (Busso and So 2010 ) characterized by monosodium urate crystal deposition in joints and soft tissues, since it causes severe pain (Parthasarathy and Vivekanandan 2018 ), may recur frequently …

Towards shortening the duration of antibiotic therapy for Lyme borreliosis: a systematic review and meta-analysis

The appropriate antibiotic prescription, at the right dose, the right duration and with the narrowest spectrum, has become a major consideration in public health for the successful treatment of bacterial infections. This is mainly due to the …

Current and future role of CT and advanced CT applications in inflammatory arthritis in the clinic and trials

Computed tomography (CT) has traditionally been underutilized in the imaging of inflammatory arthritis due to its limitations in assessing soft tissue inflammation and concerns over radiation exposure. However, recent technological advancements …

Microbial imbalance in the gut: a new frontier in Rheumatoid arthritis research

A chronic autoimmune illness that causes joint destruction and inflammation, rheumatoid arthritis (RA) often results in disability. Genetic, environmental, and immune system variables all have a role in the pathophysiology of RA. The complex …

Elevate your expertise in aplastic anemia (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

Supported by:
  • Pfizer
Developed by: Springer Healthcare IME
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CME & eLearning

eLearning (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

Supported by:
  • Pfizer
Developed by: Springer Healthcare IME

Further Reading

Paraneoplastic leukocytoclastic vasculitis mimicking ulcus cruris as rare initial manifestation of smoldering myeloma IgG kappa

Leukocytoclastic vasculitis (LCV) has been reported as a rare paraneoplastic phenomenon associated with several hematologic disorders, including indolent lymphomas such as Waldenström macroglobulinemia. However, there are very few cases of LCV in …

Real-World Safety and Efficacy of Targeted Therapies in Rheumatoid Arthritis: A 5-Year, 5130-Case Follow-Up from FIRST Registry

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by synovitis, which leads to joint destruction, physical disability, and excess mortality [ 1 ]. To prevent these consequences, therapeutic approaches have continuously …

The presumable combined effects of hydroxychloroquine and its metabolites on the blood lipids and glucose in the treatment of rheumatoid arthritis

Hydroxychloroquine (HCQ) is a weakly alkaline 4-aminoquinoline compound (Shi et al. 2019 ), first synthesized in 1944, with a similar chemical structure to chloroquine (Schrezenmeier and Dörner 2020 ). It was approved for clinical use by the U.S.

Current and future role of CT and advanced CT applications in inflammatory arthritis in the clinic and trials

Computed tomography (CT) has traditionally been underutilized in the imaging of inflammatory arthritis due to its limitations in assessing soft tissue inflammation and concerns over radiation exposure. However, recent technological advancements …

Related topics

AI to predict treatment response in RA and SpA

Artificial intelligence technologies show substantial potential in predicting treatment responses in rheumatoid arthritis and spondyloarthritis. However, challenges such as methodological variability, data integration, and external validation remain.

Read more

ALS in a patient with CLL and drug-related SLR

A man with a skin rash and left leg weakness was diagnosed with sarcoid-like reaction due to treatment for chronic lymphocytic leukemia, and ultimately also amyotrophic lateral sclerosis when the motor symptoms progressed.

Read more