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Many patients with antiphospholipid syndrome have uncontrolled cardiovascular risk factors, with primary APS patients showing particularly poor target attainment.
Ongoing research is transforming the understanding of juvenile dermatomyositis, and revealing new therapeutic and biomarker opportunities. These advances offer the potential to improve outcomes and achieve durable remission.
This case highlights that extreme reactive thrombocytosis may be part of the initial presentation of microscopic polyangiitis, potentially serving as an early diagnostic clue in the context of systemic inflammation.
Allogeneic chimeric antigen receptor therapy with natural killer cells shows promise for treating people with refractory or relapsed systemic lupus erythematosus.
People with rheumatic diseases have an increased risk for myocardial infarction, underscoring the need for early risk stratification, integrated cardio-rheumatologic care, and precision-based therapeutic strategies.
Systemic lupus erythematosus is a severe autoimmune disease that can cause damage to almost every system of the body. Learn more about novel biomarkers for diagnosis and monitoring, and familiarize yourself with current and emerging targeted therapies.
This case highlights that extreme reactive thrombocytosis may be part of the initial presentation of microscopic polyangiitis, potentially serving as an early diagnostic clue in the context of systemic inflammation.
The first case of VEXAS syndrome with features of Sjögren disease, including chronic oral sicca, high-titer SSA antibodies, a positive rheumatoid factor, and lymphopenia.
Fulminant autoimmune myocarditis was the initial manifestation of Sjögren disease, complicated by electrical storm and cardiogenic shock. Prompt initiation of corticosteroids resulted in rapid cardiac recover and successful VA-ECMO weaning.
Why are disease-modifying treatments for osteoarthritis such a difficult proposition?
Despite multiple attempts, no DMOAD is yet approved for clinical use. Prof. Ali Mobasheri takes us through the main challenges, the work being done to make these so-called utopia drugs a reality, and discusses other advances that offer hope in the meantime.
Belimumab is a human IgG1λ monoclonal antibody that inhibits B cell activating factor (BAFF), modulating B cell function through mechanisms distinct from those of anti-CD20 agents. In SLE, both belimumab and the newer biological agent …
Knee articular cartilage lesions resulting from acute or chronic injury are frequently encountered in routine clinical magnetic resonance imaging (MRI). Acute lesions typically occur following recreational or athletic activity and are often …
Patients with features of multiple systemic vasculitides are rare but do exist and can be diagnostically challenging. In particular, it can be difficult to distinguish granulomatosis with polyangiitis (GPA) with eosinophilia, proteinase 3 …
Stress is widely recognized as a significant factor contributing to the onset and exacerbation of symptoms in autoimmune diseases such as rheumatoid arthritis (RA) [ 1 , 2 ]. Exposure to stress disrupts the body’s internal balance, leading to …
Transform the way you care for your patients with aplastic anemia with our 3-module series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases.
Transform the way you care for your patients with aplastic anemia with our 3-module eLearning series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases.
Psoriatic arthritis (PsA) is a chronic, immune-mediated inflammatory disease characterized by heterogenous manifestations including peripheral arthritis, enthesitis, dactylitis, axial disease, and skin psoriasis (PsO) [ 1 ]. It is common for …
Rheumatoid arthritis (RA) is one of the most common chronic inflammatory diseases, primarily affecting the joints and presenting with extra-articular manifestations such as rheumatoid nodules, lung involvement or vasculitis, as well as other …
Fibromyalgia is defined as generalised pain lasting for at least three months, and it is typically accompanied by tender points or somatic symptoms, such as fatigue, unrefreshed sleep, and cognitive problems [ 1 ]. Fibromyalgia is estimated to …
In a large database analysis, use of GLP-1 receptor agonists was associated with a reduced symptom burden in people with fibromyalgia, but further studies with validated outcome measures are needed.
Many patients with antiphospholipid syndrome have uncontrolled cardiovascular risk factors, with primary APS patients showing particularly poor target attainment.
Understand the significance of vitamin D for bone health, especially its mechanism of action and clinical significance in bone destruction diseases such as osteoarthritis, osteoporosis, rheumatoid arthritis, and bone tuberculosis.
Adding a conventional synthetic disease-modifying antirheumatic drug to first-line systemic corticosteroid therapy may reduce treatment failure in patients with nonanterior sarcoidosis-associated uveitis.