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Adverse musculoskeletal effects of ICIs may be underestimated

Joint inflammation and erosion are as prevalent in patients who develop arthralgia after exposure to immune checkpoint inhibitors for cancer as they are in those who develop inflammatory arthritis.

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Editor's Choice

Azacitidine, tocilizumab best for VEXAS syndrome

A real-world UK study has found that azacitidine and tocilizumab are more effective than other targeted therapies for the treatment of VEXAS syndrome.

Diagnosis of 'triple-negative' primary biliary cholangitis

This case highlights the need to consider PBC when evaluating men with Sjögren disease or other autoimmune conditions when alkaline phosphatase and GGT levels are persistently elevated, even if AMA is negative.

Pulmonary arteritis in GPA

Pulmonary arteritis is a very rare manifestation of granulomatosis with polyangiitis, which typically involves small- and medium-sized vessels. But this case highlights the possibility of large-vessel inflammation.

Renal involvement in spondyloarthropathies

How prevalent are renal abnormalities across the spectrum of seronegative spondyloarthritis? And what are the associated risk factors and underlying pathophysiology?

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EULAR 2025

Explore the latest news and updates from the annual congress of the European Alliance of Associations for Rheumatology.

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Case Studies

Diagnosis of 'triple-negative' primary biliary cholangitis

This case highlights the need to consider PBC when evaluating men with Sjögren disease or other autoimmune conditions when alkaline phosphatase and GGT levels are persistently elevated, even if AMA is negative.

Pulmonary arteritis in GPA

Pulmonary arteritis is a very rare manifestation of granulomatosis with polyangiitis, which typically involves small- and medium-sized vessels. But this case highlights the possibility of large-vessel inflammation.

Novel treatment for optic neuritis

ON associated with Sjögren syndrome is uncommon and easily misdiagnosed. Conventional therapies for ON cannot control recurrence, but this case suggests telitacicept might be a promising option.

Keynote webinar | Spotlight on advances in lupus

Systemic lupus erythematosus is a severe autoimmune disease that can cause damage to almost every system of the body. Learn more about novel biomarkers for diagnosis and monitoring, and familiarize yourself with current and emerging targeted therapies.

Prof. Edward Vital
Prof. Ronald F. van Vollenhoven
Developed by: Springer Medicine
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Current Reviews

Clinical risk factors associated with cage migration after posterior approaches for lumbar interbody fusion: a 10-year systematic review and meta-analysis

Posterior approaches for lumbar interbody fusion include transforaminal lumbar interbody fusion (TLIF), posterior lumbar interbody fusion (PLIF), and minimally invasive surgery transforaminal lumbar interbody fusion (MIS-TLIF) and so on. Such …

Gout, Hyperuricemia, and the Intestinal Microbiome

  • Open Access
  • Gout
  • Review

Gout is a disease of hyperuricemia (HU) leading to monosodium urate crystal deposition in the joint, resulting in inflammation and joint damage. Recently, efforts have been made to characterize the intestinal microbiome of patients who suffer from …

Kaempferol as a multi-targeted phytotherapeutic for arthritis: systematic review and meta-analysis of preclinical models

Arthritis, including rheumatoid arthritis (RA), osteoarthritis (OA), and gouty arthritis (GA), is a major cause of disability worldwide. Current treatments have limited efficacy and adverse effects, prompting interest in natural alternatives.

CAR-T cells in systemic sclerosis

Systemic sclerosis (SSc) is a complex disease with extensive fibrosis, microvasculopathy, and autoantibodies. Activation of the adaptive immune system involving T cells, B cells, and macrophages along with microvasculopathy is considered early …

Episode 17: Challenges of developing DMOADs

Why are disease-modifying treatments for osteoarthritis such a difficult proposition?

Despite multiple attempts, no DMOAD is yet approved for clinical use. Prof. Ali Mobasheri takes us through the main challenges, the work being done to make these so-called utopia drugs a reality, and discusses other advances that offer hope in the meantime.

Prof. Ali Mobasheri
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Podcast

CME & eLearning

eLearning (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

Supported by:
  • Pfizer
Developed by: Springer Health+ IME

Further Reading

Patient Profile and Outcomes Among Patients with Rheumatoid Arthritis Treated with Baricitinib Versus Other Therapies in Spain: The RA-BE-REAL Study

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterised by inflammation that leads to joint swelling and deformity, bone erosion, and pain [ 1 , 2 ]. RA affects multiple joints in a symmetrical pattern and can also present …

Crosstalk between ferroptosis and NLRP3, a possible therapeutic target in experimentally-induced rheumatoid arthritis: role of P2Y12R inhibition in modulating P53/SLC7A11/ALOX15 signaling

Ferroptosis is critical in progressing and exacerbating rheumatoid arthritis (RA) and other inflammatory joint diseases. Inhibition of the P2Y12 receptors reduced iron overload in macrophages displaying an anti-inflammatory response. Herein, the …

Efficacy and Safety of Deucravacitinib, a Selective, Allosteric TYK2 Inhibitor, by Baseline DMARD Use in a Phase 2 Psoriatic Arthritis Study: A Post Hoc Analysis

This article is published with digital features, including a graphical abstract, to facilitate understanding of the article. To view digital features for this article, go to https://doi.org/10.6084/m9.figshare.29077367 .

Related topics

Adverse musculoskeletal effects of ICIs may be underestimated

Joint inflammation and erosion are as prevalent in patients who develop arthralgia after exposure to immune checkpoint inhibitors for cancer as they are in those who develop inflammatory arthritis.

Read more

Heterotopic ossification after wrist replacement

The first reported case of heterotopic ossification following total wrist arthroplasty. Revision surgery was performed to remove ossifications and no further signs have been reported, but the patient's range of motion remains reduced.

Read more

DMARDs boost treatment success in nonanterior sarcoidosis-associated uveitis

Adding a conventional synthetic disease-modifying antirheumatic drug to first-line systemic corticosteroid therapy may reduce treatment failure in patients with nonanterior sarcoidosis-associated uveitis.

Read more