Skip to main content

Atypical presentation of purulent pericardial effusion in SLE patient

A rare case of purulent pericardial effusion secondary to methicillin-sensitive Staphylococcus aureus in a patient with systemic lupus erythematosus that highlights asymptomatic bacteriuria as a potential early indicator.

Read more

Editor's Choice

Emerging therapeutics in rheumatoid arthritis

Explore recent advances in precision medicine and novel targeted therapies in rheumatoid arthritis, which may lead to better disease control or possibly cure in the future.

Reaching target urate level linked to lower MACE risk in gout

  • 05-02-2026
  • Gout
  • News

The 5-year risk for major adverse cardiovascular events in people with gout is significantly lower if they achieve the serum urate-lowering treatment target than if they do not.

Abatacept delays onset of RA long-term in at-risk individuals

Treatment with abatacept for 1 year can delay the onset of rheumatoid arthritis for up to 4 years in individuals at high risk for the condition.

Immune thrombocytopenia in connective tissue disease

What are the clinical and pathological features of immune thrombocytopenia secondary to systemic lupus erythematosus and Sjögren syndrome? And how can current and emerging therapeutic strategies improve outcomes?

Our tailored content service will keep you up to date…

Receive newsletters curated for the busy specialist by our expert editorial team

Aplastic anemia: managing special patient subgroups and challenging cases (Link opens in a new window)

Learn more about the importance of adapting treatment approaches for special patient populations (eg, elderly or pregnant patients) in this third module of our interactive e-Learning program on diagnosing and treating aplastic anemia.

Supported by:
  • Pfizer
Developed by: Springer Health+ IME
Learn more

Case Studies

Atypical presentation of purulent pericardial effusion in SLE patient

A rare case of purulent pericardial effusion secondary to methicillin-sensitive Staphylococcus aureus in a patient with systemic lupus erythematosus that highlights asymptomatic bacteriuria as a potential early indicator.

From infection to infarction: CMV retinitis in JAK inhibition

An 81-year-old receiving upadacitinib for rheumatoid arthritis developed CMV retinitis complicated by delayed retinal ischemia and vitreous hemorrhage. Clinicians should be vigilant for atypical ocular complications from JAK inhibitors.

Strawberry gingiva: a mucosal clue to systemic vasculitis

A disease flare in this patient with granulomatosis with polyangiitis was indicated by strawberry gingiva. Early recognition of SG is essential for timely diagnosis and it also serves as a valuable marker of therapeutic response.

Episode 24: Looking back at 2025

Advancing patient care

In this special edition of Medicine Matters, we're joined by Dr Gregory Lim, Claire Greenhill, and Sarah Onuora, Chief Editors of Nature Reviews Cardiology, Endocrinology, and Rheumatology, for a look back at the advances in their specialties in 2025.

Find out what caught their attention and why, and what they're looking forward to in 2026.

Gregory Lim
Claire Greenhill
Sarah Onuora
Listen now
Podcast

Current Reviews

Septic knee: multimodality approach

Septic arthritis of the knee is an acute infection that can rapidly destroy articular cartilage if not promptly recognized and treated. Early diagnosis is often difficult because symptoms overlap with crystal or inflammatory arthropathies and …

Light Treatment for PTSD: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis evaluated the efficacy of light therapy in reducing PTSD symptoms across six randomized controlled trials (RCTs), including 312 participants. Standardized mean differences (SMDs) were calculated, revealing …

Otolaryngologic manifestations in granulomatosis with Polyangitis: A systematic review of clinical presentations and renal correlation

Granulomatosis with polyangiitis (GPA) is a systemic vasculitis characterized by necrotizing granulomatous inflammation affecting small- and medium-sized blood vessels. The disease predominantly targets the respiratory tract and kidneys, but the …

Paraneoplastic dermatomyositis with atypical features associated with a solid pseudopapillary pancreatic neoplasm

Dermatomyositis (DM) is an autoimmune inflammatory myopathy that may occur as a paraneoplastic syndrome, most commonly associated with ovarian, lung, and gastrointestinal malignancies. Solid pseudopapillary pancreatic tumor is a rare neoplasm with …

Keynote webinar | Spotlight on advances in lupus

Systemic lupus erythematosus is a severe autoimmune disease that can cause damage to almost every system of the body. Learn more about novel biomarkers for diagnosis and monitoring, and familiarize yourself with current and emerging targeted therapies.

Prof. Edward Vital
Prof. Ronald F. van Vollenhoven
Watch now
Video

CME & eLearning

Aplastic anemia (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module eLearning series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

Supported by:
  • Pfizer
Developed by: Springer Health+ IME

Further Reading

FDG uptake in upper abdominal lymph node as a distinctive pattern in sarcoidosis

Sarcoidosis is a multisystem granulomatous disease that has nonspecific clinical manifestations that commonly affect the pulmonary system in at least 90% of sarcoidosis patients. In 10–30% of cases there is involvement of other organs such as the …

Nanoencapsulated Sirolimus Plus Pegadricase (NASP) in Uncontrolled Gout: Current Status and Future Directions

  • Open Access
  • Gout
  • Leading Article

Uncontrolled gout (UG) is a progressive arthropathy that develops as a consequence of sustained hyperuricemia. Recombinant uricases can profoundly lower serum urate (SU) and reverse the clinical manifestations of uncontrolled gout. However …

Novel clinical application of urinary angiotensin-converting enzyme assay in renal sarcoidosis: a retrospective observational study

Sarcoidosis is a systemic inflammatory disease characterized by non-caseating granulomas, mainly affecting the lungs, eyes, and skin [ 1 – 4 ]. The prevalence of renal involvement ranges from approximately −1% to 5% [ 2 , 4 – 6 ]. Common renal …

Exploratory evaluation of early 68Ga-FAPI-46 PET/CT volume-based parameters in systemic sclerosis-associated interstitial lung disease

Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is a major cause of morbidity and mortality in systemic sclerosis [ 1 ]. Its clinical course is highly heterogeneous with 30% exhibiting progressive decline [ 2 – 4 ]. Current …

Related topics

DMARDs boost treatment success in nonanterior sarcoidosis-associated uveitis

Adding a conventional synthetic disease-modifying antirheumatic drug to first-line systemic corticosteroid therapy may reduce treatment failure in patients with nonanterior sarcoidosis-associated uveitis.

Read more
Image Credits
ECG of SLE patient with pericardial effusion/© 2026, Nora Spadoni et al, J Med Case Reports, Syringe and multicolored pills on a grey background/© Towfiqu Barbhuiya / stock.adobe.com, Chart with downward trend/© Nostagrams / stock.adobe.com, Person using prefilled syringe or pen injection/© M.Dörr & M.Frommherz / stock.adobe.com, Small reddish spots on skin/© Dr. Hans Schulz, Bergkamen, Aplastic Anemia/© Springer Healthcare IME, Widefield fluorescein angiogram showing retinal ischemia/© 2026, Ciera D. Johnson et al, BMC Ophthalmol, Imaging of ANCA-associated vasculitis patient with strawberry gingiva/© 2026, Luis CaraballoLuque Caraballo et al, under exclusive licence to International League of Associations for Rheumatology (ILAR), Clin Rheumatol, Medicine Matters Podcast promo image/© Springer Medizin GmbH, Lupus concept/© (M) Vitalii But / stock.adobe.com / Generated with AI, Incretin mimetic injectors/© aprott/ Getty Images / iStock, Scan of toddler’s spine to position the needle for a lumbar sympathetic block to treat complex regional pain syndrome/© 2024, Amany E. Ayad et al, Pain Ther, Woman using a smartphone/© Jajah-sireenut / Getty Images / iStock (symbolic image with model), Man having a coughing episode/© kostyha / stock.adobe.com (symbolic image with model), Stretchy skin in Ehlers-Danlos syndrome/© Biophoto Associates / Science Photo Library, Nervous system illustration/© vefimov / stock.adobe.com (symbolic image with model), Close-up of man with both hands on knee/© Jacob Wackerhausen / Getty Images / iStock, Close-up of person massaging their hand/© Jacob Wackerhausen / Getty Images / iStock, Vitamin D capsules/© NiseriN / Getty Images / iStock, Weighing scales and measuring tape/© Atlas / stock.adobe.com, Woman doing stretches in bedroom/© Galina Zhigalova / Getty Images / iStock (symbolic image with model), X-rays of patient with heterotopic ossification after wrist replacement/© 2025, Sonja Verena Schmidt et al, J Med Case Reports, Close-up of gloved hand filling syringe from a vial/© New Africa / stock.adobe.com, Leg ulcers in patient with ulcerative cutaneous sarcoidosis/© 2025, Nabil Belfeki et al, under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature, Rheumatol Int, Skin rash in patient with ALS, CLL, and SLR/© 2025, Joumana Freiha et al, BMC Neurol, 3D render of circulatory system/© magicmine / Stock.adobe.com, Placing a catheter for administering IV drugs/© flywish / stock.adobe.com, ECG during implant demonstrating activation during left branch bundle area pacing/© Hopman et al. BMC Cardiovasc Disord 23, 621 (2023) (CC BY 4.0)