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Internal Medicine Rheumatology

Rheumatology

CAR T-cell therapy in systemic sclerosis

Immunosuppressives form the foundation of systemic sclerosis treatment but there remains an unmet therapeutic need. Treatment with CAR T cells has shown promise but challenges, such as cost, need to be addressed.

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Editor's Choice

Rare manifestation of dermatomyositis

A young woman initially presenting with erythroderma went on to be diagnosed with dermatomyositis. This case highlights that cutaneous manifestations can precede the onset of clinical muscle weakness. 

Boosting physical activity in older RA patients

Delve into the current evidence on rehabilitation interventions to enhance physical function in older adults with rheumatoid arthritis, and get practical recommendations to support your patients in becoming more active.

Adverse musculoskeletal effects of ICIs may be underestimated

Joint inflammation and erosion are as prevalent in patients who develop arthralgia after exposure to immune checkpoint inhibitors for cancer as they are in those who develop inflammatory arthritis.

Azacitidine, tocilizumab best for VEXAS syndrome

A real-world UK study has found that azacitidine and tocilizumab are more effective than other targeted therapies for the treatment of VEXAS syndrome.

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Keynote webinar | Spotlight on advances in lupus

Systemic lupus erythematosus is a severe autoimmune disease that can cause damage to almost every system of the body. Learn more about novel biomarkers for diagnosis and monitoring, and familiarize yourself with current and emerging targeted therapies.

Prof. Edward Vital
Prof. Ronald F. van Vollenhoven
Developed by: Springer Medicine
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Latest News

No increase in cancer risk with JAK inhibitors in RA

Reassuring findings for zoster vaccine use in inflammatory RMDs

Reduction in MACE risk an additional benefit of treat to target in gout

  • 19-06-2025
  • Gout
  • News

Better axSpA outcomes after intervention with Axia app

T2T strategy with secukinumab effective in PsA in STAMP study

Vectorcardiography identifies SSc patients at high risk for PH

Case Studies

Rare manifestation of dermatomyositis

A young woman initially presenting with erythroderma went on to be diagnosed with dermatomyositis. This case highlights that cutaneous manifestations can precede the onset of clinical muscle weakness. 

Diagnosis of 'triple-negative' primary biliary cholangitis

This case highlights the need to consider PBC when evaluating men with Sjögren disease or other autoimmune conditions when alkaline phosphatase and GGT levels are persistently elevated, even if AMA is negative.

Pulmonary arteritis in GPA

Pulmonary arteritis is a very rare manifestation of granulomatosis with polyangiitis, which typically involves small- and medium-sized vessels. But this case highlights the possibility of large-vessel inflammation.

Episode 17: Challenges of developing DMOADs

Why are disease-modifying treatments for osteoarthritis such a difficult proposition?

Despite multiple attempts, no DMOAD is yet approved for clinical use. Prof. Ali Mobasheri takes us through the main challenges, the work being done to make these so-called utopia drugs a reality, and discusses other advances that offer hope in the meantime.

Prof. Ali Mobasheri
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Podcast

Current Reviews

Nrf2 signaling pathway: focus on oxidative stress in osteoporosis

The nuclear factor erythrocyte 2-related factor-2 (Nrf2) signaling pathway is an important regulatory factor for bone homeostasis in osteoporosis. It is also regarded as a key pathway of antioxidant stress and is closely related to the …

Distinguish between systemic sclerosis and localised scleroderma (morphoea) to ensure appropriate treatment

Systemic sclerosis (SSc) and localised scleroderma (also known as morphoea) are two distinct autoimmune diseases that are both associated with skin sclerosis. Although there are pathogenic pathways common to both diseases, treatment of each …

Comparison of Advances and Current Intraarticular Injectables in Treating Temporomandibular Joint Osteoarthritis—A Scoping Review of the Past 10 Years

TMJ-AC is considered an indirect, minimally invasive surgery that involves washout of the superior compartment of the joint space. AC can be performed via two techniques: single-needle or double-needle puncture. [ 1 – 4 ] AC can also be combined …

The role of physical performance measures in the physiotherapy assessment and management of older adults with osteoporotic vertebral fractures: a narrative review

Osteoporotic vertebral fractures (OVFs) are the most common major osteoporotic fractures [ 1 – 3 ] and are associated with substantial morbidity, decreased survival [ 4 , 5 ], and economic burden [ 6 ]. OVFs can place people at risk of a subsequent …

Elevate your expertise in aplastic anemia (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

Supported by:
  • Pfizer
Developed by: Springer Health+ IME
Learn more

Most Viewed in Rheumatology

Late-onset RA: what you need to know

Lupus induced by shingles vaccine

CME & eLearning

eLearning (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

Supported by:
  • Pfizer
Developed by: Springer Health+ IME

Editor's Choice | Rheumatology

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Further Reading

Leucine-rich alpha-2-glycoprotein 1 (LRG1) decrement during biologics therapy and its correlation with disease features and treatment outcomes in rheumatoid arthritis patients

Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects mainly females, with an estimated global prevalence of 0.46% [ 1 , 2 ]. Profiting from the progress of the biopharmaceutical industry, several novel kinds of drugs have been …

Efficacy and Safety of Biosimilar CT-P47 Versus Reference Tocilizumab: 1-Year Results of a Randomised, Active-Controlled, Double-Blind, Phase III Study in Patients with Rheumatoid Arthritis

Overproduction of the proinflammatory cytokine interleukin-6 (IL-6) is implicated in the pathogenesis of a number of autoimmune diseases, including rheumatoid arthritis (RA), in which IL-6 plays a pivotal role [ 1 – 3 ]. This pivotal role is …

Contemporary pharmacological management of patients after hip fracture: a population-based cohort of over 120,000 patients in Spain

The USA, Europe, India, and Japan concentrate an estimated 125 million people suffering from osteoporosis [ 1 ]. Osteoporotic fractures, and among them hip fractures—the worst outcome of osteoporosis—represent the majority of the economic and …

Effect of FRAXplus adjustments on fracture risk reclassification in older Swedish women—results from the SUPERB-study

Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to increased bone fragility and fracture risk [ 1 ]. Fractures are associated with significant morbidity …

Related topics

Another promising signal for GLP-1 drugs, this time in fibromyalgia

In a large database analysis, use of GLP-1 receptor agonists was associated with a reduced symptom burden in people with fibromyalgia, but further studies with validated outcome measures are needed.

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Lumbar sympathetic block to treat CRPS in a toddler

Self-guided digital behavioral therapy for fibromyalgia

Caution needed when prescribing gabapentinoids in people with COPD

Illness uncertainty in hypermobile Ehlers-Danlos syndrome

Neurostimulation therapies for chronic pain

CAR T-cell therapy in systemic sclerosis

Immunosuppressives form the foundation of systemic sclerosis treatment but there remains an unmet therapeutic need. Treatment with CAR T cells has shown promise but challenges, such as cost, need to be addressed.

Read more

Rare manifestation of dermatomyositis

Boosting physical activity in older RA patients

Adverse musculoskeletal effects of ICIs may be underestimated

Diagnosis of 'triple-negative' primary biliary cholangitis

Pulmonary arteritis in GPA

Heterotopic ossification after wrist replacement

The first reported case of heterotopic ossification following total wrist arthroplasty. Revision surgery was performed to remove ossifications and no further signs have been reported, but the patient's range of motion remains reduced.

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Trial supports metformin use in osteoarthritis

Osteoporosis and osteoarthritis in elderly patients

Biomarkers in hand osteoarthritis

Use of platelet-rich plasma in rheumatic diseases

Are heated mittens useful in osteoarthritis?

DMARDs boost treatment success in nonanterior sarcoidosis-associated uveitis

Adding a conventional synthetic disease-modifying antirheumatic drug to first-line systemic corticosteroid therapy may reduce treatment failure in patients with nonanterior sarcoidosis-associated uveitis.

Read more

Ulcerative cutaneous sarcoidosis: a diagnostic challenge

ALS in a patient with CLL and drug-related SLR

Cardio-rheumatology: an emerging specialty

Corticosteroids for hydrocephalus in neurosarcoidosis

Complications from conduction system pacing

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