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Internal Medicine Rheumatology

Rheumatology

Lifelong follow-up needed for children undergoing HCT for NMDs

Late toxic effects are common in children who undergo allogenic hematopoietic cell transplantation for nonmalignant diseases and therefore require lifelong follow-up.

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Editor's Choice

Metabolic syndrome and bone quality

How do metabolic syndrome, its components, and related diseases impact bone quality, and what is the latest view on the contribution made by bone-derived cytokines?

Lumbar sympathetic block to treat CRPS in a toddler

After non-invasive measures failed, a lumbar sympathetic block performed with extreme caution alleviated complex regional pain syndrome in this 18-month-old.

Managing gout and metabolic syndrome

Gout is associated with metabolic syndrome and its related comorbid conditions. Find out more about the clinical challenge that is managing both conditions in the same patient.

Self-guided digital behavioral therapy for fibromyalgia

A 12-week self-guided digital acceptance and commitment therapy program is safe and effective for adults with fibromyalgia, improving associated symptoms including fatigue and sleep disturbance.

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Case Studies

Lumbar sympathetic block to treat CRPS in a toddler

After non-invasive measures failed, a lumbar sympathetic block performed with extreme caution alleviated complex regional pain syndrome in this 18-month-old.

Misdiagnosis of pulmonary artery sarcoma

A pulmonary arterial sarcoma was mistaken as pulmonary vasculitis due to similarities between the diagnoses. This case highlights some cardinal features of the malignancy that are not seen in vasculitis.

A challenging diagnosis of lung cancer

Although uncommon, lung cancer in patients with granulomatosis with polyangiitis can be difficult to diagnose due to similarities in imaging findings.

Current Reviews

Cardiovascular Outcomes of Uric Acid Lowering Medications: A Meta-Analysis

Hyperuricemia has been associated with an increased incidence of cardiovascular diseases, including coronary artery disease (CAD) [ 1 – 3 ], heart failure (HF) [ 4 ], atrial fibrillation (AF) [ 5 , 6 ], and hypertension [ 7 ], in addition to an …

Vitamin D and hip protectors in osteosarcopenia: a combined hip fracture preventing approach

Osteosarcopenia is an emerging clinical condition highly prevalent in the older people. Affected subjects due to their intrinsic skeletal fragility and propensity to falls are at elevated risk of hip fractures which can increase morbidity and …

Allogenic haematopoietic stem cell transplantation in VEXAS: A review of 33 patients

Vacuolation, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is a multisystem disease due to a genetic mutation in the ubiquitin-activating enzyme (UBA1). Allogeneic haematopoietic stem cell transplantation (allo-HSCT) offers both …

Deciphering the Etiologies of Adult Erythroderma: An Updated Guide to Presentations, Diagnostic Tools, Pathophysiologies, and Treatments

Erythroderma, an inflammatory skin condition characterized by widespread erythema with variable degrees of exfoliation, pustulation, or vesiculobullous formation, is associated with high morbidity and mortality. Determining the underlying cause of …

Further Reading

A radiographic artificial intelligence tool to identify candidates suitable for partial knee arthroplasty

  • Open Access
  • Knee-TEP
  • Knee Arthroplasty

The prevalence of knee osteoarthritis is increasing, and it already affects one quarter of the UK’s population [ 1 ]. Knee replacement surgery is a successful treatment option for patients with end-stage symptomatic knee osteoarthritis who have …

Belimumab 10 years later: how drug positioning has changed

We analysed the change in the positioning of belimumab (BLM) in systemic lupus erythematosus (SLE) treatment in the first decade of real-life use, by providing data about patients treated by this biological drug in the Sapienza Lupus Cohort. We …

Genetic Evaluation of the Patients with Clinically Diagnosed Inborn Errors of Immunity by Whole Exome Sequencing: Results from a Specialized Research Center for Immunodeficiency in Türkiye

Molecular diagnosis of inborn errors of immunity (IEI) plays a critical role in determining patients’ long-term prognosis, treatment options, and genetic counseling. Over the past decade, the broader utilization of next-generation sequencing (NGS) …

18q Deletion Syndrome Presenting with Late-Onset Combined Immunodeficiency

Patients with chromosome 18q deletion syndrome generally experience hypogammaglobulinemia. Herein, we describe two patients with chromosome 18q deletion syndrome who presented with late-onset combined immune deficiency (LOCID), which has not been …