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Internal Medicine Rheumatology

Rheumatology

Semaglutide shows promise for obesity-related osteoarthritis

STEP 9 trial results suggest that treatment with semaglutide may significantly reduce both bodyweight and knee pain in people with obesity and knee osteoarthritis.

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Editor's Choice

Romosozumab for the treatment of osteoporosis

The monoclonal antibody romosozumab has a transient but robust bone anabolic effect. Find out what is currently known about its clinical efficacy and safety for the treatment of primary and secondary osteoporosis.

Triple vessel spontaneous CAD in polyarteritis nodosa

Triple-vessel spontaneous coronary artery dissection and polyarteritis nodosa are both extremely rare. Their coexistence is exceptional and presents unique diagnostic and therapeutic challenges.

Combined treatment for PML

Progressive multifocal leukoencephalopathy is an often fatal CNS disease caused by JC virus infection. In this case, low-dose, long-term immunoglobulin plus mirtazapine resulted in a controlled inflammatory reaction.

Osteoporosis medication underused after fragility fractures

Less than a third of patients who experience a fragility fracture fill a prescription for osteoporosis medication in the year after injury.

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Case Studies

Triple vessel spontaneous CAD in polyarteritis nodosa

Triple-vessel spontaneous coronary artery dissection and polyarteritis nodosa are both extremely rare. Their coexistence is exceptional and presents unique diagnostic and therapeutic challenges.

Combined treatment for PML

Progressive multifocal leukoencephalopathy is an often fatal CNS disease caused by JC virus infection. In this case, low-dose, long-term immunoglobulin plus mirtazapine resulted in a controlled inflammatory reaction.

Lumbar sympathetic block to treat CRPS in a toddler

After non-invasive measures failed, a lumbar sympathetic block performed with extreme caution alleviated complex regional pain syndrome in this 18-month-old.

Current Reviews

Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation

Pain, a complex symptom encompassing both sensory and emotional dimensions, constitutes a significant global public health issue. Oxidative stress is a pivotal factor in the complex pathophysiology of pain, with glutathione peroxidase 4 (GPX4) …

Vunakizumab: First Approval

Vunakizumab (安达静®) is a subcutaneous (SC) recombinant anti-interleukin (IL)-17A humanized monoclonal IgG1/κ antibody being developed by Suzhou Suncadia Biopharmaceutical Co., Ltd (a subsidiary of Jiangsu Hengrui Pharmaceuticals Co., Ltd) for the …

An Update on Emerging Regenerative Medicine Applications: The Use of Extracellular Vesicles and Exosomes for the Management of Chronic Pain

  • Osteoarthrosis
  • Alternative Treatments for Pain Medicine (C Robinson, Section Editor)

Nearly two billion people worldwide are affected by chronic pain conditions, yet there remains a dearth of effective treatments for it [ 1 ]. With an estimated inflation-adjusted cost of $863 billion to the US healthcare system ($635 billion in …

Targeting the NLRP3 inflammasome–IL-1β pathway in type 2 diabetes and obesity

Increased activity of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome–IL-1β pathway is observed in obesity and contributes to the development of type 2 diabetes and its complications. In this review, we describe the …

Further Reading

Nationwide database study of postoperative sequelae and in-hospital mortality in super-elderly hip fracture patients

Hip fractures are a common orthopedic injury in the elderly, with high morbidity and mortality rates [ 1 , 2 ]. The number of hip fractures worldwide is expected to reach 4,500,000 by 2050 [ 3 ]. The elderly population in the United States …

Real-Life Data of Secukinumab in Patients with Moderate to Severe Plaque Psoriasis, Psoriatic Arthritis, and Ankylosing Spondylitis: Patient Baseline Characteristics Data from the PROMPT Study

Psoriasis (PsO), psoriatic arthritis (PsA), and axial spondyloarthritis (axSpA) or ankylosing spondylitis (AS) are chronic inflammatory diseases occurring worldwide [ 1 , 2 ]. The complex interaction between environmental, genetic, and immune …

Xanthogranulomatous pyelonephritis in a child with autoimmune joint disease

Xanthogranulomatous pyelonephritis is a rare condition in paediatric patients, mostly described in middle-aged female patients. We present a 7-year-old female with juvenile idiopathic arthritis, who was found to have a kidney mass with a …

COVID-19 vaccination-related delayed adverse events among people with rheumatoid arthritis: results from the international COVAD survey

This study aimed to assess COVID-19 vaccination-related AEs in patients with rheumatoid arthritis (RA), in the COVID-19 Vaccination in Autoimmune Diseases (COVAD)-2 study. An online international cross-sectional survey captured self-reported data …