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Internal Medicine Rheumatology

Rheumatology

Leaky gut: causes, diseases, and therapy

Excessive intestinal barrier permeability is increasingly being diagnosed, but what do we know about the causes and potential health consequences? Can intestinal barrier damage be prevented or repaired?

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Editor's Choice

Lifelong follow-up needed for children undergoing HCT for NMDs

Late toxic effects are common in children who undergo allogenic hematopoietic cell transplantation for nonmalignant diseases and therefore require lifelong follow-up.

Metabolic syndrome and bone quality

How do metabolic syndrome, its components, and related diseases impact bone quality, and what is the latest view on the contribution made by bone-derived cytokines?

Lumbar sympathetic block to treat CRPS in a toddler

After non-invasive measures failed, a lumbar sympathetic block performed with extreme caution alleviated complex regional pain syndrome in this 18-month-old.

Managing gout and metabolic syndrome

Gout is associated with metabolic syndrome and its related comorbid conditions. Find out more about the clinical challenge that is managing both conditions in the same patient.

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Case Studies

Lumbar sympathetic block to treat CRPS in a toddler

After non-invasive measures failed, a lumbar sympathetic block performed with extreme caution alleviated complex regional pain syndrome in this 18-month-old.

Misdiagnosis of pulmonary artery sarcoma

A pulmonary arterial sarcoma was mistaken as pulmonary vasculitis due to similarities between the diagnoses. This case highlights some cardinal features of the malignancy that are not seen in vasculitis.

A challenging diagnosis of lung cancer

Although uncommon, lung cancer in patients with granulomatosis with polyangiitis can be difficult to diagnose due to similarities in imaging findings.

Current Reviews

Successful treatment of Crohn’s disease-related peripheral spondyloarthritis with upadacitinib: two case reports and case-based review

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease (CD), not only causes significant intestinal inflammation but also leads to extra-intestinal manifestations such as spondyloarthritis (SpA). Although the efficacy …

Review of the updated definitions and concepts of spinal lesions in axial spondyloarthritis

Spinal imaging may support the diagnosis of axial spondyloarthritis when typical findings are recognized in an appropriate clinical context and it can also indicate disease activity. In May 2022, the definitions for inflammatory and structural …

Paraneoplastic systemic lupus erythematosus associated with dysgerminoma: a case report and literature review

Rheumatic paraneoplastic syndromes are rare and generally occur no longer than two years before diagnosis of the associated malignancy. Therefore, it can be an essential clue to occult malignancy. A healthy 18-year-old female with no underlying …

Cerebrovascular implications of takayasu arteritis: a review

Takayasu arteritis (TA) is a rare form of vasculitis, primarily affecting young women, that causes inflammation of large vessels, particularly the aorta and its main branches. Given its quick onset and nonspecific symptoms, TA poses diagnostic …

Further Reading

The uncertain correlation of ANCAs in patients with lupus nephritis and crescents, an experience from Chinese centers

Systemic lupus erythematosus (SLE) is a disease involving multiple organs and is associated with several serum autoantibodies, including anti-neutrophil cytoplasmic antibodies (ANCAs). The reported prevalence of ANCAs varies greatly, with some …

Real-World Evidence of Clinical Outcomes of the Use of the Adalimumab Biosimilar SB5 in Rheumatic and Gastrointestinal Immune-Mediated Inflammatory Diseases: 12-Month Data from the PERFUSE Study

  • Open Access
  • Adalimumab
  • Original Research Article

Immune-mediated inflammatory diseases (IMIDs) form a clinically diverse group of disorders affecting between 3 and 7% of the population in whom altered immune regulation causes chronic organ-specific and systemic inflammation [ 1 , 2 ]. While they …

Cerebrovascular implications of takayasu arteritis: a review

Takayasu arteritis (TA) is a rare form of vasculitis, primarily affecting young women, that causes inflammation of large vessels, particularly the aorta and its main branches. Given its quick onset and nonspecific symptoms, TA poses diagnostic …

Evaluation of different standard and modified two-tier testing strategies for the laboratory diagnosis of lyme borreliosis in a European setting

Lyme borreliosis (LB) is caused by infection with Ixodes -transmitted spirochetes of the Borrelia burgdorferi sensu lato (s.l.) complex, and is the most prevalent tick-borne disease in the Northern Hemisphere. In North America, B. burgdorferi sensu …