The FcRn blocker nipocalimab significantly improves clinical disease activity in people with moderate-to-severe Sjögren disease and could be a promising approach for these patients.
A proof-of-concept study suggests that treatment with the JAK inhibitor tofacitinib could increase skeletal muscle mass in patients with rheumatoid arthritis.
Another case report contributing to the growing body of literature on gastrointestinal involvement in systemic lupus erythematosus, and underscoring the importance of early recognition and targeted treatment.
Explore recent progress in clinical and molecular endotyping of primary Sjögren disease, and understand how these insights can inform the development of precision treat-to-target strategies.
A young man with antiphospholipid syndrome presented with left main coronary artery STEMI. Through a novel strategy combining drug-coated balloon angioplasty and anticoagulation and immunomodulation therapy, the patient displayed sustained patency without recurrent thrombosis at one year follow up.
Systemic lupus erythematosus is a severe autoimmune disease that can cause damage to almost every system of the body. Learn more about novel biomarkers for diagnosis and monitoring, and familiarize yourself with current and emerging targeted therapies.
Another case report contributing to the growing body of literature on gastrointestinal involvement in systemic lupus erythematosus, and underscoring the importance of early recognition and targeted treatment.
A young man with antiphospholipid syndrome presented with left main coronary artery STEMI. Through a novel strategy combining drug-coated balloon angioplasty and anticoagulation and immunomodulation therapy, the patient displayed sustained patency without recurrent thrombosis at one year follow up.
Axial proptosis, conjunctival congestion, chemosis, and a corneal perforation with iris prolapse revealed underlying granulomatosis with polyangiitis, requiring systemic immunosuppression, antibiotics, and a bandage contact lens.
Why are disease-modifying treatments for osteoarthritis such a difficult proposition?
Despite multiple attempts, no DMOAD is yet approved for clinical use. Prof. Ali Mobasheri takes us through the main challenges, the work being done to make these so-called utopia drugs a reality, and discusses other advances that offer hope in the meantime.
Kawasaki disease (KD) is an acute multisystem vasculitis that represents the leading cause of acquired pediatric heart disease in children aged 1–5 years in developed nations. The diagnosis of KD remains clinically challenging due to its diverse …
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic syndrome) is an adult-onset autoinflammatory disorder caused by somatic mutations in the UBA1 gene. While its clinical spectrum is expanding, the overlap with autoimmune diseases …
Rheumatoid arthritis (RA), an autoimmune disease characterized by chronic, symmetric, and erosive polyarthritis, can lead to joint destruction, deformity, and functional impairment. In its early stages, radiographic imaging typically reveals …
Compared to non-surgical management, vertebral augmentation offers faster pain relief, faster functional mobility, and lower morbidity/mortality (level of evidence: high) Vertebral augmentation should be performed 3–6 weeks after the fracture event …
Transform the way you care for your patients with aplastic anemia with our 3-module series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases.
Transform the way you care for your patients with aplastic anemia with our 3-module eLearning series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases.
Autosomal dominant tubulointerstitial kidney disease (ADTKD-UMOD) is a chronic and progressive kidney disease that typically presents with elevated serum creatinine and gout between the second and fourth decades of life. Our patient presented at …
Mucocutaneous involvement is the hallmark of Behçet’s disease (BD) and often represents the only clinical manifestation for an extended period in these patients. Specifically, mucocutaneous involvement includes the presence of oral aphthosis …
A seminal study in the early 1970 s revealed the immune system’s capacity to enhance bone resorption and osteoclast activity, highlighting the interplay between the skeletal and immune systems. This discovery gave rise to the burgeoning field of …
This qualitative study enriched the understanding of patient attitudes towards parenteral methotrexate by employing the Theoretical Framework of Acceptability and addressing gaps in the literature. High patient acceptance of parenteral methotrexate …
In a large database analysis, use of GLP-1 receptor agonists was associated with a reduced symptom burden in people with fibromyalgia, but further studies with validated outcome measures are needed.
The FcRn blocker nipocalimab significantly improves clinical disease activity in people with moderate-to-severe Sjögren disease and could be a promising approach for these patients.
Understand the significance of vitamin D for bone health, especially its mechanism of action and clinical significance in bone destruction diseases such as osteoarthritis, osteoporosis, rheumatoid arthritis, and bone tuberculosis.
Adding a conventional synthetic disease-modifying antirheumatic drug to first-line systemic corticosteroid therapy may reduce treatment failure in patients with nonanterior sarcoidosis-associated uveitis.
