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Strawberry gingiva: a mucosal clue to systemic vasculitis

A disease flare in this patient with granulomatosis with polyangiitis was indicated by strawberry gingiva. Early recognition of SG is essential for timely diagnosis and it also serves as a valuable marker of therapeutic response.

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Editor's Choice

Concomitant dermatomyositis and IgA nephropathy

An extremely rare case of dermatomyositis concomitant with IgA nephropathy. Although the possibility of coincidental co-occurrence cannot be ruled out, it seems more likely that a common pathologic mechanism plays a role.

Vagus nerve-targeted neuromodulation an option for RA?

Neuroimmune modulation via a vagus nerve-targeted implantable device significantly improves rheumatoid arthritis symptoms, offering patients a first-in-class nonpharmacologic treatment option.

Bruxism and rheumatic diseases: what's the relationship?

A possible bidirectional relationship may exist between bruxism and inflammatory rheumatic diseases, mediated by temporomandibular joint pathology but also by central sensitization, psychological factors, and inflammatory pathways.

Subcutaneous anifrolumab feasible in SLE

Weekly subcutaneous anifrolumab shows treatment benefits for patients with systemic lupus erythematosus consistent with those seen with the monthly intravenous formulation.

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Aplastic anemia: managing special patient subgroups and challenging cases (Link opens in a new window)

Learn more about the importance of adapting treatment approaches for special patient populations (eg, elderly or pregnant patients) in this third module of our interactive e-Learning program on diagnosing and treating aplastic anemia.

Supported by:
  • Pfizer
Developed by: Springer Health+ IME
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Case Studies

Strawberry gingiva: a mucosal clue to systemic vasculitis

A disease flare in this patient with granulomatosis with polyangiitis was indicated by strawberry gingiva. Early recognition of SG is essential for timely diagnosis and it also serves as a valuable marker of therapeutic response.

Concomitant dermatomyositis and IgA nephropathy

An extremely rare case of dermatomyositis concomitant with IgA nephropathy. Although the possibility of coincidental co-occurrence cannot be ruled out, it seems more likely that a common pathologic mechanism plays a role.

Macrophage activation syndrome following varicella

Common infections can trigger macrophage activation syndrome. This case of a 10-year-old girl developing MAS during the convalescence period after varicella highlights the complexities of MAS diagnosis.

Episode 24: Looking back at 2025

Advancing patient care

In this special edition of Medicine Matters, we're joined by Dr Gregory Lim, Claire Greenhill, and Sarah Onuora, Chief Editors of Nature Reviews Cardiology, Endocrinology, and Rheumatology, for a look back at the advances in their specialties in 2025.

Find out what caught their attention and why, and what they're looking forward to in 2026.

Gregory Lim
Claire Greenhill
Sarah Onuora
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Podcast

Current Reviews

Management of Patients with Asthma, COPD, and OSA in Outpatient Unit: ACOSOU—Global Perspectives and Challenges

Obstructive sleep apnea (OSA) is increasingly recognized as a major comorbidity in chronic respiratory diseases, particularly asthma and chronic obstructive pulmonary disease (COPD). The coexistence of OSA with asthma or COPD significantly …

Diosgenin-mediated NF-κB and MAPK pathway modulation for osteoarthritis treatment: molecular mechanisms, bioavailability enhancement, and therapeutic applications

The review has comprehensively examined the therapeutic potential of phytoconstituents in the treatment of arthritis with specific emphasis being given to diosgenin as a promising natural molecule. Arthritis is a significant health concern in the …

Multiple cerebral venous thrombosis as the first presentation of Behçet syndrome: case report and literature review

Behçet syndrome (BS) is a multisystem disease that is more common in male patients, affecting the recurrent oral and genital ulcers, as well as the ocular, skin, gastrointestinal, neurological, vascular, and locomotor systems. In nonselected big …

Non-metastatic breast cancer patients discontinuing aromatase inhibitor on denosumab: what next?

Aromatase inhibitors (AIs) are one of the adjuvant endocrine therapies of choice, for estrogen receptor-positive breast cancer in postmenopausal women and premenopausal women with ovarian suppression. However, treatment with AIs leads to …

Keynote webinar | Spotlight on advances in lupus

Systemic lupus erythematosus is a severe autoimmune disease that can cause damage to almost every system of the body. Learn more about novel biomarkers for diagnosis and monitoring, and familiarize yourself with current and emerging targeted therapies.

Prof. Edward Vital
Prof. Ronald F. van Vollenhoven
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Video

CME & eLearning

Aplastic anemia (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module eLearning series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

Supported by:
  • Pfizer
Developed by: Springer Health+ IME

Further Reading

Patients’ Perspectives Regarding Ankylosing Spondylitis Treatment Administration Features: Evidence from Qualitative Interviews and a Multinational Quantitative Preference Survey

Ankylosing spondylitis (AS, also called radiographic axial spondyloarthritis or r-axSpA) is a chronic, immune-mediated inflammatory arthritis that primarily affects the sacroiliac joints and the spine, with disease activity increasing with age [ 1 …

Features Associated with Therapy Switch Among PPD CorEvitas Psoriasis Registry Patients

Psoriasis is a chronic inflammatory disease characterized by skin lesions that can affect any area of the body [ 1 , 2 ]. Treatment for psoriasis is generally based on disease activity, such that patients with moderate-to-severe disease may require …

Diosgenin-mediated NF-κB and MAPK pathway modulation for osteoarthritis treatment: molecular mechanisms, bioavailability enhancement, and therapeutic applications

The review has comprehensively examined the therapeutic potential of phytoconstituents in the treatment of arthritis with specific emphasis being given to diosgenin as a promising natural molecule. Arthritis is a significant health concern in the …

Effect of protein supplementation on hip bone mineral density, cortical thickness, and bone strength in older adult participants during a caloric restriction and aerobic exercise weight loss intervention: a randomized controlled trial

Obesity affects over one-third of older adults, but intentional weight loss (WL) is associated with bone loss and fracture risk in this population [ 1 , 2 ]. Despite WL benefits in reducing clinical consequences of obesity, musculoskeletal losses …

Related topics

taVNS of limited benefit in erosive osteoarthritis

Transcutaneous auricular vagus nerve stimulation does not significantly improve hand pain relative to sham stimulation in people with erosive hand osteoarthritis, but may benefit certain subgroups.

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DMARDs boost treatment success in nonanterior sarcoidosis-associated uveitis

Adding a conventional synthetic disease-modifying antirheumatic drug to first-line systemic corticosteroid therapy may reduce treatment failure in patients with nonanterior sarcoidosis-associated uveitis.

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Image Credits
Imaging of ANCA-associated vasculitis patient with strawberry gingiva/© 2026, Luis CaraballoLuque Caraballo et al, under exclusive licence to International League of Associations for Rheumatology (ILAR), Clin Rheumatol, Hand of patient with IgA nephropathy and dermatomyositis/© 2025, Md. Gias Uddin et al, under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature, Vagus nerves, illustration/© SEBASTIAN KAULITZKI / SCIENCE PHOTO LIBRARY / Getty Images, Woman with pain in her jaw/© agenturfotografin / stock.adobe.com (symbolic image with model), Close-up of woman receiving injection in arm/© leolintang / Getty Images / iStock, Aplastic Anemia/© Springer Healthcare IME, Confluent hemorrhagic rashes around ankle joint /© 2025, H. Mateiko et al, J Med Case Reports, Medicine Matters Podcast promo image/© Springer Medizin GmbH, Lupus concept/© (M) Vitalii But / stock.adobe.com / Generated with AI, Incretin mimetic injectors/© aprott/ Getty Images / iStock, Scan of toddler’s spine to position the needle for a lumbar sympathetic block to treat complex regional pain syndrome/© 2024, Amany E. Ayad et al, Pain Ther, Woman using a smartphone/© Jajah-sireenut / Getty Images / iStock (symbolic image with model), Man having a coughing episode/© kostyha / stock.adobe.com (symbolic image with model), Stretchy skin in Ehlers-Danlos syndrome/© Biophoto Associates / Science Photo Library, Nervous system illustration/© vefimov / stock.adobe.com (symbolic image with model), Close-up of person massaging their hand/© Jacob Wackerhausen / Getty Images / iStock, Vitamin D capsules/© NiseriN / Getty Images / iStock, Weighing scales and measuring tape/© Atlas / stock.adobe.com, Woman doing stretches in bedroom/© Galina Zhigalova / Getty Images / iStock (symbolic image with model), X-rays of patient with heterotopic ossification after wrist replacement/© 2025, Sonja Verena Schmidt et al, J Med Case Reports, Woman taking medication/© ozgurcankaya / Getty Images / iStock (symbolic image with model), Close-up of gloved hand filling syringe from a vial/© New Africa / stock.adobe.com, Leg ulcers in patient with ulcerative cutaneous sarcoidosis/© 2025, Nabil Belfeki et al, under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature, Rheumatol Int, Skin rash in patient with ALS, CLL, and SLR/© 2025, Joumana Freiha et al, BMC Neurol, 3D render of circulatory system/© magicmine / Stock.adobe.com, Placing a catheter for administering IV drugs/© flywish / stock.adobe.com, ECG during implant demonstrating activation during left branch bundle area pacing/© Hopman et al. BMC Cardiovasc Disord 23, 621 (2023) (CC BY 4.0)