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Telitacicept for SLE and pregnancy: some reassurance

A woman with systemic lupus erythematosus and lupus nephritis became pregnant while taking a telitacicept-containing regimen. Telitacicept was promptly discontinued and she eventually delivered a healthy infant.

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Editor's Choice

Tirzepatide boosts ixekizumab benefits in patients with PsA and obesity

Combining ixekizumab with tirzepatide offers additive clinical benefits over ixekizumab alone in the treatment of psoriatic arthritis in patients with overweight or obesity.

Stroke in autoimmune rheumatic diseases

Patients with ARDs have a significantly increased risk for stroke. Review the epidemiology, pathophysiological mechanisms, clinical characteristics, prevention strategies, and post-stroke rehabilitation in this patient population.

Findings support treat-to-target for gout

  • 03-04-2026
  • Gout
  • News

A treat-to-target approach may be better than symptom-driven care for improving long-term gout control without increasing the risk for adverse events.

Insights into autoimmune-related DED

Autoimmune-related dry eye disease is often refractory to conventional first-line treatments, with anti-inflammatory and immunomodulatory therapies instead crucial for long-term control. This stepwise approach provides insights from real-world cases.

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Keynote webinar | Spotlight on dry eye disease

  • Live
  • Webinar | 28-05-2026 | 13:00 (CEST)

DED is highly prevalent yet challenging to diagnose and treat. Join leading experts to explore the latest developments and gain practical guidance on effective management in busy clinical settings. Brought to you by Springer Medicine and Eye.

Watch it live: 28 May 2026, 13:00–14:00 (CEST)

Prof. Harminder Dua
Prof. Sajjad Ahmad
Prof. Anat Galor
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Webinar

Case Studies

Telitacicept for SLE and pregnancy: some reassurance

A woman with systemic lupus erythematosus and lupus nephritis became pregnant while taking a telitacicept-containing regimen. Telitacicept was promptly discontinued and she eventually delivered a healthy infant.

Complications in a patient with VEXAS syndrome

This case highlights the importance of heightened clinical suspicion, early identification, and treatment of macrophage activation syndrome in individuals with VEXAS syndrome.

GPA masquerading as a hydatid cyst

A woman with a history of hepatic echinococcosis presented with pulmonary lesions that did not improve with antiparasitic therapy, prompting rheumatologic evaluation and a diagnosis of granulomatosis with polyangiitis.

SLE: translating guidelines into practice (Link opens in a new window)

Equip yourself to confidently implement the latest evidence-based strategies for your patients with systemic lupus erythematosus with this program. Expert-led videos on topics including the updated EULAR 2023 guidelines available now.

Independent Medical Education Grant:
  • AstraZeneca
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Current Reviews

Chimeric antigen receptor macrophage (CAR-M) immunotherapy in autoimmune inflammatory rheumatic diseases

Chronic autoimmune inflammatory rheumatic diseases (AIRD), such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), juvenile idiopathic arthritis, systemic sclerosis (SSc), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) …

Potential of CAR-T cell immunotherapy in rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and joint destruction. Despite the availability of various treatment options, many patients remain refractory to conventional therapies. Recent advancements in …

A narrative review: key evidence from meta-analyses in nuclear medicine

Recent progress in nuclear medicine has been driven by continuous advances in radiotracers, imaging technologies, and radiopharmaceutical therapies, leading to an expansion of clinical applications supported by an increasing body of evidence. In …

Potential of chimeric antigen receptor (CAR) T cell immunotherapy in systemic lupus erythematosus (SLE)

Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease characterized by multiorgan inflammation due to the dysregulation of the immune system. Despite the availability of conventional immunosuppressive therapies, the management of SLE …

Episode 24: Looking back at 2025

Advancing patient care

In this special edition of Medicine Matters, we're joined by Dr Gregory Lim, Claire Greenhill, and Sarah Onuora, Chief Editors of Nature Reviews Cardiology, Endocrinology, and Rheumatology, for a look back at the advances in their specialties in 2025.

Find out what caught their attention and why, and what they're looking forward to in 2026.

Gregory Lim
Claire Greenhill
Sarah Onuora
Listen now
Podcast

CME & eLearning

SLE: translating guidelines into practice (Link opens in a new window)

Equip yourself to confidently implement the latest evidence-based strategies for your patients with systemic lupus erythematosus with this program. Expert-led videos on topics including the updated EULAR 2023 guidelines available now.

Independent Medical Education Grant:
  • AstraZeneca

Further Reading

A narrative review: key evidence from meta-analyses in nuclear medicine

Recent progress in nuclear medicine has been driven by continuous advances in radiotracers, imaging technologies, and radiopharmaceutical therapies, leading to an expansion of clinical applications supported by an increasing body of evidence. In …

Screening of osteoporosis in patients with ANCA-associated vasculitis (AAV) is quite low: results from a country-wide study

Patients with ANCA-associated vasculitis (AAV) are at increased risk of osteoporosis due to multiple disease- and treatment-related factors. However, real-world data on osteoporosis screening practices in this population remain limited. The aim of …

Actinomyces lesions and acute inflammation predominate in osteonecrosis of the jaw associated with osteoclast-suppressing therapy in contrast to non-medication-related osteonecrosis

Patients with malignant bone metastases/lesions or osteoporosis receiving osteoclast-suppressive antiresorptive medications such as bisphosphonates (BP), denosumab, or possibly romosozumab, may develop medication-related osteonecrosis of the jaw …

Baseline serum PINP is associated with early lumbar spine bone mineral density gains during twice-weekly teriparatide treatment: the OASIS cohort study

Fractures and the subsequent deterioration in quality of life impose a substantial burden on patients with osteoporosis. In recent years, novel therapeutic options—particularly bone anabolic agents—have become available [ 1 – 5 ], and the 2024 …

Related topics

Pancreatic cancer or isolated pancreatic sarcoidosis?

Acute pancreatitis was diagnosed in a woman who presented with abdominal pain. Imaging raised suspicion for obstructive pancreatitis secondary to pancreatic cancer, but later investigations revealed a more unusual cause.

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Image Credits
Woman holding positive pregnancy test/© Nutlegal / stock.adobe.com (symbolic image with model), Woman receiving injection/© Antonio_Diaz / Getty Images / iStock (symbolic image with models), Stroke illustration/© Thipphaphone / Generated with AI / stock.adobe.com, Papercraft image of an arrow hitting a target/© MirageC / Moment / Getty, Clinical images of elderly male with SS-associated dry eye disease/© 2026, Giuseppe Giannaccare et al, Ophthalmol Ther (CC BY 4.0), Conceptual illustration of dry eye disease/© Science Photo Library / Getty Images, Risk meter concept/© Cagkan / Stock.adobe.com, Close-up of doctor giving subcutaneous injection in patient's stomach/© Victoria Kotlyarchuk / Getty Images / iStock, Nurse with IV drip and patient in hospital room/© Halfpoint / Stock.adobe.com (symbolic image with models), Close-up of woman showing mouth ulcer on inner lower lip/© Marija Bazarova / Getty Images / iStock (symbolic image with model), Blood test vials/© Oleg Elkov / Getty Images / iStock, Histopathology of patient with granulomatosis with polyangiitis/© 2026, Tuba Yuce Inel et al, under exclusive licence to International League of Associations for Rheumatology, Clin Rheumatol, Butterfly logo superimposed over silhouettes of people/© Springer Health+ IME, Medicine Matters Podcast promo image/© Springer Medizin GmbH, Infrared visualization of shoulder pain or injury/© mikkelwilliam / Getty Images / iStock, Girl covering one eye with her hand/© patpitchaya / Getty Images / iStock (symbolic image with model), Electromyography exam in hospital/© VILevi / Fotolia (symbolic image with models), Woman with shoulder pain/© C Davids / peopleimages.com / Stock.adobe.com (symbolic image with model), Woman with pain in her hand/© Satjawat / Stock.adobe.com (symbolic image with model), Incretin mimetic injectors/© aprott / Getty Images / iStock, Scan of toddler’s spine to position the needle for a lumbar sympathetic block to treat complex regional pain syndrome/© 2024, Amany E. Ayad et al, Pain Ther, Woman using a smartphone/© Jajah-sireenut / Getty Images / iStock (symbolic image with model), Man having a coughing episode/© kostyha / stock.adobe.com (symbolic image with model), Close-up of man with both hands on knee/© Jacob Wackerhausen / Getty Images / iStock, Close-up of person massaging their hand/© Jacob Wackerhausen / Getty Images / iStock, Vitamin D capsules/© NiseriN / Getty Images / iStock, Weighing scales and measuring tape/© Atlas / stock.adobe.com, Woman doing stretches in bedroom/© Galina Zhigalova / Getty Images / iStock (symbolic image with model), X-rays of patient with heterotopic ossification after wrist replacement/© 2025, Sonja Verena Schmidt et al, J Med Case Reports, Combined PET and CT imaging of the pancreas in a patient with pancreatic sarcoidosis/© 2026, Nao Ishidoya et al, Clin J Gastroenterol, under exclusive licence to Japanese Society of Gastroenterology, Close-up of gloved hand filling syringe from a vial/© New Africa / stock.adobe.com, Leg ulcers in patient with ulcerative cutaneous sarcoidosis/© 2025, Nabil Belfeki et al, under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature, Rheumatol Int, Skin rash in patient with ALS, CLL, and SLR/© 2025, Joumana Freiha et al, BMC Neurol, 3D render of circulatory system/© magicmine / Stock.adobe.com, Placing a catheter for administering IV drugs/© flywish / stock.adobe.com