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Internal Medicine Rheumatology

Rheumatology

Managing gout and metabolic syndrome

Gout is associated with metabolic syndrome and its related comorbid conditions. Find out more about the clinical challenge that is managing both conditions in the same patient.

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Editor's Choice

Self-guided digital behavioral therapy for fibromyalgia

A 12-week self-guided digital acceptance and commitment therapy program is safe and effective for adults with fibromyalgia, improving associated symptoms including fatigue and sleep disturbance.

How diet can reduce CV risk in patients with autoimmune disease

Cardiovascular diseases are more prevalent in individuals with autoimmune diseases than in the general population. Is systemic inflammation the driver? Can nutritional interventions reduce the risk of CV complications in these individuals? 

Emergencies in inflammatory rheumatic diseases

Inflammatory rheumatic diseases are chronic disorders, but they can manifest as severe and life-threatening emergencies. Discover the critical situations that can occur and how to improve outcomes.

Cushing’s disease and bone

Bone complications are common in people with Cushing’s disease. Screening for fractures is encouraged, diagnosis should focus on assessing bone quality, and therapy needs to be multifactorial.

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Case Studies

Misdiagnosis of pulmonary artery sarcoma

A pulmonary arterial sarcoma was mistaken as pulmonary vasculitis due to similarities between the diagnoses. This case highlights some cardinal features of the malignancy that are not seen in vasculitis.

A challenging diagnosis of lung cancer

Although uncommon, lung cancer in patients with granulomatosis with polyangiitis can be difficult to diagnose due to similarities in imaging findings.

Delayed diagnosis of APAP in patient with dermatomyositis

Differentiating autoimmune pulmonary alveolar proteinosis (APAP) from a flare-up of interstitial pneumonia associated with dermatomyositis is challenging. This case highlights the need for early APAP scrutiny.

Current Reviews

Fractures of the thoracolumbar spine in osteoporosis

Due to increasing life expectancy, the prevalence of fractures caused by osteoporosis is raising. These fractures significantly reduce the quality of life in the elderly population. They represent both a disease and an injury simultaneously. While …

Management of hip osteoarthritis: harnessing the potential of mesenchymal stem cells—a systematic review

Osteoarthritis (OA) is a chronic disease that affects the joint and surrounding tissues, causing progressive damage to the articular cartilage [ 1 , 2 ]. OA is associated with health implications for the affected patients and burdens the healthcare …

The Fracture Phenotypes in Women and Men of 50 Years and Older with a Recent Clinical Fracture

The high and increasing burden of fractures in subjects older than 50 years has been documented worldwide [ 1 , 2 ], whereas there are growing insights in fracture prediction and a wide spectrum and availability of treatments to prevent fractures [ …3

Three cases of relapsed eosinophilic sinusitis without eosinophilia during mepolizumab maintenance therapy for eosinophilic granulomatosis with polyangiitis

We present three cases of eosinophilic granulomatosis with polyangiitis (EGPA) where patients experienced relapse of eosinophilic sinusitis without peripheral eosinophilia while on remission maintenance therapy with mepolizumab (MPZ), an …

Further Reading

Better restoration of joint line obliquity in tibia first restricted kinematic alignment versus mechanical alignment TKA

Total knee arthroplasty (TKA) is a commonly performed surgical procedure for patients with severe knee osteoarthritis, aiming to relieve pain, improve joint function, and enhance quality of life [ 1 , 2 ]. Despite the success of TKA, achieving …

Early Improvements with Guselkumab Associate with Sustained Control of Psoriatic Arthritis: Post hoc Analyses of Two Phase 3 Trials

Psoriatic arthritis (PsA) is a systemic inflammatory disease affecting multiple domains: peripheral arthritis, enthesitis, dactylitis, axial disease, skin psoriasis, and nail involvement [ 1 ]. PsA is associated with impairment of functional status …

Identification of genetic association between mitochondrial dysfunction and knee osteoarthritis through integrating multi-omics: a summary data-based Mendelian randomization study

Knee osteoarthritis (KOA) is a common musculoskeletal disease among middle-aged and elderly individuals, characterized by chronic pain and functional disability [ 1 ]. It involves pathological changes in all joint tissues, including synovitis …

Fractures of the thoracolumbar spine in osteoporosis

Due to increasing life expectancy, the prevalence of fractures caused by osteoporosis is raising. These fractures significantly reduce the quality of life in the elderly population. They represent both a disease and an injury simultaneously. While …