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Internal Medicine Rheumatology

Rheumatology

High rate of relapse after adalimumab discontinuation in JIA

Stopping adalimumab treatment after 1 year often leads to disease recurrence in patients with juvenile idiopathic arthritis-associated uveitis, suggest the ADJUST trial findings.

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Editor's Choice

How to diagnose rheumatoid meningitis

RM is a rare cause of chronic meningitis. Diagnosis is challenging due to its varied clinical manifestations and the absence of recognized criteria. This case illustrates what you need to look for.

Biomarkers in hand osteoarthritis

Explore the current research into biomarkers for early diagnosis, prognosis, disease severity assessment, and therapeutic response in hand osteoarthritis. Are any ready for prime time?

Late-onset systemic lupus erythematosus

How does the natural history of late-onset SLE – initial diagnosis after 50–65 years – differ from that of classical SLE? And what are the key considerations for diagnosis and treatment in this population?

Gouty lumbar spinal stenosis

  • Open Access
  • Gout
  • Case Study

An unusual case of lumbar spinal stenosis caused by gouty tophi in a 26-year-old man. Physicians should be alert to the possibility of spinal gout in patients who present with back pain.

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Case Studies

How to diagnose rheumatoid meningitis

RM is a rare cause of chronic meningitis. Diagnosis is challenging due to its varied clinical manifestations and the absence of recognized criteria. This case illustrates what you need to look for.

Gouty lumbar spinal stenosis

  • Open Access
  • Gout
  • Case Study

An unusual case of lumbar spinal stenosis caused by gouty tophi in a 26-year-old man. Physicians should be alert to the possibility of spinal gout in patients who present with back pain.

JAK inhibition promising for refractory Behçet’s disease

A patient with Behçet's disease refractory to standard therapies, and complicated by uveitis and axial spondyloarthritis, responded to treatment with upadacitinib, pointing to a role for JAK inhibition in this setting.

Current Reviews

Upper Extremity and Musculoskeletal Injuries Related to Videogame and Augmented Reality Game Usage: A Narrative Review Article

The videogame industry has evolved considerably over the last half a century. The origin of videogames began in the late 1950s when, using one of the Brookhaven National Laboratory’s large research computers, an American physicist created the …

Evaluating treatment responsiveness in rheumatoid arthritis through predictive metabolomic profiling: A systematic review of studies examining methotrexate, TNF, and IL-6 inhibitors as therapeutic interventions

Rheumatoid arthritis (RA) is a systemic chronic autoimmune disease characterized by joint damage and systemic involvement. Despite advancements in understanding RA, early diagnosis and effective treatment remain challenging due to the complex …

Ultrasonography in the assessment of calcium pyrophosphate deposition disease

Calcium pyrophosphate deposition (CPPD) disease is an arthropathy with increasing prevalence in the aging population that is associated with significant musculoskeletal morbidity. Although synovial fluid analysis (SFA) has been considered the gold …

Imaging in clinical trials for psoriatic arthritis: a scoping review

Psoriatic arthritis (PsA) is a chronic inflammatory condition principally affecting the skin and musculoskeletal system, associated with comorbidities and decreased quality of life. Imaging is crucial for diagnosis, monitoring progression, and …

Further Reading

Upper Extremity and Musculoskeletal Injuries Related to Videogame and Augmented Reality Game Usage: A Narrative Review Article

The videogame industry has evolved considerably over the last half a century. The origin of videogames began in the late 1950s when, using one of the Brookhaven National Laboratory’s large research computers, an American physicist created the …

Safety of Janus kinase inhibitors in rheumatoid arthritis: a disproportionality analysis using FAERS database from 2012 to 2022

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation. It affects between 0.5 and 1% of the adult population and is observed two to three times more frequently in women than in men [ 1 , 2 ]. The …

Prevalence, Clinical Features, and Extraintestinal Manifestations in Patients with Familial Inflammatory Bowel Diseases

Inflammatory bowel diseases (IBD) including Crohn's disease (CD), ulcerative colitis (UC), and indeterminate colitis (IC), are chronic progressive and disabling diseases often diagnosed in young adulthood. The disease course is heterogeneous …

The global burden of osteoarthritis knee: a secondary data analysis of a population-based study

Osteoarthritis knee, a chronic and degenerative joint disease [ 1 , 2 ], stands as a formidable health challenge across the globe [ 3 ]. It is characterized by the gradual breakdown of cartilage in the knee joint, leading to pain, stiffness, and …