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Disease-modifying therapies in lupus nephritis

Of the current treatments for lupus nephritis, how many can be classed as disease modifying according to recently proposed criteria? And what are the challenges and considerations for future studies?

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Editor's Choice

Upadacitinib may offer a glucocorticoid-sparing option for GCA

Upadacitinib once daily, combined with glucocorticoid taper, may be more effective than placebo for inducing sustained remission in patients with giant cell arteritis.

Early atypical MRI findings in Neuro-Behçet's disease

For pediatric patients with unexplained neurological symptoms and MRI findings showing lateral ventricular lesions or brainstem-thalamus-basal ganglia abnormalities, monitor closely for BD signs: recurrent oral and genital ulcers, skin lesions, and eye involvement.

Gout and psoriatic disease: an evolving conundrum

  • Free for a limited time
  • Gout
  • Review

The overlap between gout and psoriatic disease has been known since the 1980s. But what are the key mechanisms underlying this association, how does it influence management, and should "Psout" be considered a novel disease?

SLE presenting with bilateral retinal vasculitis

A unique case of bilateral retinal vasculitis as the initial manifestation of systemic lupus erythematosus. Recognizing the possibility of such atypical presentations allows clinicians to maintain a high index of suspicion for SLE.

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Episode 17: Challenges of developing DMOADs

Why are disease-modifying treatments for osteoarthritis such a difficult proposition?

Despite multiple attempts, no DMOAD is yet approved for clinical use. Prof. Ali Mobasheri takes us through the main challenges, the work being done to make these so-called utopia drugs a reality, and discusses other advances that offer hope in the meantime.

Prof. Ali Mobasheri
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Podcast

Case Studies

Early atypical MRI findings in Neuro-Behçet's disease

For pediatric patients with unexplained neurological symptoms and MRI findings showing lateral ventricular lesions or brainstem-thalamus-basal ganglia abnormalities, monitor closely for BD signs: recurrent oral and genital ulcers, skin lesions, and eye involvement.

SLE presenting with bilateral retinal vasculitis

A unique case of bilateral retinal vasculitis as the initial manifestation of systemic lupus erythematosus. Recognizing the possibility of such atypical presentations allows clinicians to maintain a high index of suspicion for SLE.

Digital vasculitis as rare presentation of anti-synthetase syndrome

The patient presented with digital vasculitis, rapidly evolving interstitial lung disease, sub-clinical myositis, and arthritis of the hands with no prior history of Raynaud’s phenomenon. What antibodies would you test to determine the final diagnosis?

Keynote webinar | Spotlight on advances in lupus

  • Live
  • Webinar | 27-05-2025 | 18:00 (CEST)

Systemic lupus erythematosus is a severe autoimmune disease that can cause damage to almost every system of the body. Join this session to learn more about novel biomarkers for diagnosis and monitoring and familiarise yourself with current and emerging targeted therapies.

Join us live: Tuesday 27th May, 18:00-19:15 (CEST)

Prof. Edward Vital
Prof. Ronald F. van Vollenhoven
Developed by: Springer Medicine
Register now
Webinar

Current Reviews

Towards shortening the duration of antibiotic therapy for Lyme borreliosis: a systematic review and meta-analysis

The appropriate antibiotic prescription, at the right dose, the right duration and with the narrowest spectrum, has become a major consideration in public health for the successful treatment of bacterial infections. This is mainly due to the …

Current and future role of CT and advanced CT applications in inflammatory arthritis in the clinic and trials

Computed tomography (CT) has traditionally been underutilized in the imaging of inflammatory arthritis due to its limitations in assessing soft tissue inflammation and concerns over radiation exposure. However, recent technological advancements …

Microbial imbalance in the gut: a new frontier in Rheumatoid arthritis research

A chronic autoimmune illness that causes joint destruction and inflammation, rheumatoid arthritis (RA) often results in disability. Genetic, environmental, and immune system variables all have a role in the pathophysiology of RA. The complex …

Role of polyphenolics in the management of rheumatoid arthritis through intracellular signaling pathways: a mechanistic review

Inflammation of the joints, bone erosion, and cartilage destruction are the main characteristics of rheumatoid arthritis (RA) which causes joint malfunction, structural distortion, and long-term impairment of function. According to various …

Elevate your expertise in aplastic anemia (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

Supported by:
  • Pfizer
Developed by: Springer Healthcare IME
Learn more

CME & eLearning

eLearning (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

Supported by:
  • Pfizer
Developed by: Springer Healthcare IME

Further Reading

The presumable combined effects of hydroxychloroquine and its metabolites on the blood lipids and glucose in the treatment of rheumatoid arthritis

Hydroxychloroquine (HCQ) is a weakly alkaline 4-aminoquinoline compound (Shi et al. 2019 ), first synthesized in 1944, with a similar chemical structure to chloroquine (Schrezenmeier and Dörner 2020 ). It was approved for clinical use by the U.S.

Current and future role of CT and advanced CT applications in inflammatory arthritis in the clinic and trials

Computed tomography (CT) has traditionally been underutilized in the imaging of inflammatory arthritis due to its limitations in assessing soft tissue inflammation and concerns over radiation exposure. However, recent technological advancements …

Treatment Considerations for Severe Osteoporosis in Older Adults

Osteoporosis, a chronic metabolic bone disease, increases the predisposition to fragility fractures and is associated with considerable morbidity, high health care cost as well as mortality. An elevation in the rate of incident fragility fractures …

Early clinical outcomes of Naton robotic-assisted medial unicompartmental knee arthroplasty

Unicompartmental knee arthroplasty (UKA) is recognized as a relatively minimally invasive knee replacement procedure that offers advantages such as reduced surgical trauma, less blood loss, faster recovery, maximal preservation of knee bone stock …

Related topics

Disease-modifying therapies in lupus nephritis

Of the current treatments for lupus nephritis, how many can be classed as disease modifying according to recently proposed criteria? And what are the challenges and considerations for future studies?

Read more

ALS in a patient with CLL and drug-related SLR

A man with a skin rash and left leg weakness was diagnosed with sarcoid-like reaction due to treatment for chronic lymphocytic leukemia, and ultimately also amyotrophic lateral sclerosis when the motor symptoms progressed.

Read more