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CV risk factors and target attainment a concern in APS

Many patients with antiphospholipid syndrome have uncontrolled cardiovascular risk factors, with primary APS patients showing particularly poor target attainment.

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Editor's Choice

New insights into juvenile dermatomyositis

Ongoing research is transforming the understanding of juvenile dermatomyositis, and revealing new therapeutic and biomarker opportunities. These advances offer the potential to improve outcomes and achieve durable remission.

Extreme thrombocytosis as initial presentation of vasculitis

This case highlights that extreme reactive thrombocytosis may be part of the initial presentation of microscopic polyangiitis, potentially serving as an early diagnostic clue in the context of systemic inflammation. 

CAR NK-cell therapy shows potential for refractory lupus

Allogeneic chimeric antigen receptor therapy with natural killer cells shows promise for treating people with refractory or relapsed systemic lupus erythematosus.

Myocardial infarction in rheumatic diseases

People with rheumatic diseases have an increased risk for myocardial infarction, underscoring the need for early risk stratification, integrated cardio-rheumatologic care, and precision-based therapeutic strategies.

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Keynote webinar | Spotlight on advances in lupus

Systemic lupus erythematosus is a severe autoimmune disease that can cause damage to almost every system of the body. Learn more about novel biomarkers for diagnosis and monitoring, and familiarize yourself with current and emerging targeted therapies.

Prof. Edward Vital
Prof. Ronald F. van Vollenhoven
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Video

Case Studies

Extreme thrombocytosis as initial presentation of vasculitis

This case highlights that extreme reactive thrombocytosis may be part of the initial presentation of microscopic polyangiitis, potentially serving as an early diagnostic clue in the context of systemic inflammation. 

VEXAS syndrome presenting with Sjögren's features

The first case of VEXAS syndrome with features of Sjögren disease, including chronic oral sicca, high-titer SSA antibodies, a positive rheumatoid factor, and lymphopenia.

Sjögren disease manifesting as fulminant myocarditis

Fulminant autoimmune myocarditis was the initial manifestation of Sjögren disease, complicated by electrical storm and cardiogenic shock. Prompt initiation of corticosteroids resulted in rapid cardiac recover and successful VA-ECMO weaning.

Episode 17: Challenges of developing DMOADs

Why are disease-modifying treatments for osteoarthritis such a difficult proposition?

Despite multiple attempts, no DMOAD is yet approved for clinical use. Prof. Ali Mobasheri takes us through the main challenges, the work being done to make these so-called utopia drugs a reality, and discusses other advances that offer hope in the meantime.

Prof. Ali Mobasheri
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Podcast

Current Reviews

Beyond systemic lupus erythematosus: a systematic review on the use of belimumab in other connective tissue diseases and vasculitides

Belimumab is a human IgG1λ monoclonal antibody that inhibits B cell activating factor (BAFF), modulating B cell function through mechanisms distinct from those of anti-CD20 agents. In SLE, both belimumab and the newer biological agent …

Acute and chronic injury of the knee articular cartilage: prevalence, injury mechanisms, MRI assessment and association with osteoarthritis

Knee articular cartilage lesions resulting from acute or chronic injury are frequently encountered in routine clinical magnetic resonance imaging (MRI). Acute lesions typically occur following recreational or athletic activity and are often …

Glucocorticoid-free remission with simultaneous mepolizumab and rituximab in life-threatening PR3-ANCA-positive eosinophilic granulomatosis with polyangiitis: a case report and literature review

Patients with features of multiple systemic vasculitides are rare but do exist and can be diagnostically challenging. In particular, it can be difficult to distinguish granulomatosis with polyangiitis (GPA) with eosinophilia, proteinase 3 …

The impact of 24-h occupational stress on C-reactive protein and pain in a patient with rheumatoid arthritis: a 40-day prospective case study and literature review

Stress is widely recognized as a significant factor contributing to the onset and exacerbation of symptoms in autoimmune diseases such as rheumatoid arthritis (RA) [ 1 , 2 ]. Exposure to stress disrupts the body’s internal balance, leading to …

Elevate your expertise in aplastic anemia (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

Supported by:
  • Pfizer
Developed by: Springer Health+ IME
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CME & eLearning

Aplastic anemia (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module eLearning series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

Supported by:
  • Pfizer
Developed by: Springer Health+ IME

Further Reading

Effectiveness of Tofacitinib in Patients with Psoriatic Arthritis Initiating Monotherapy Versus Combination Therapy: Results from the CorEvitas Psoriatic Arthritis/Spondyloarthritis Registry

Psoriatic arthritis (PsA) is a chronic, immune-mediated inflammatory disease characterized by heterogenous manifestations including peripheral arthritis, enthesitis, dactylitis, axial disease, and skin psoriasis (PsO) [ 1 ]. It is common for …

Filgotinib Effectiveness in Rheumatoid Arthritis: Observational Analysis of a Large Multicenter Cohort

Rheumatoid arthritis (RA) is one of the most common chronic inflammatory diseases, primarily affecting the joints and presenting with extra-articular manifestations such as rheumatoid nodules, lung involvement or vasculitis, as well as other …

UK Medical Cannabis Registry: a case series analysing clinical outcomes of medicinal cannabis therapy for fibromyalgia

Fibromyalgia is defined as generalised pain lasting for at least three months, and it is typically accompanied by tender points or somatic symptoms, such as fatigue, unrefreshed sleep, and cognitive problems [ 1 ]. Fibromyalgia is estimated to …

Anti-CD74 IgA as a potential biomarker in axial spondyloarthritis: diagnostic utility and clinical implications

Axial spondyloarthritis (axSpA) is a chronic inflammatory rheumatic disease which affect axial skeleton mainly [ 1 ].

Related topics

Vitamin D and bone health

Understand the significance of vitamin D for bone health, especially its mechanism of action and clinical significance in bone destruction diseases such as osteoarthritis, osteoporosis, rheumatoid arthritis, and bone tuberculosis.

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DMARDs boost treatment success in nonanterior sarcoidosis-associated uveitis

Adding a conventional synthetic disease-modifying antirheumatic drug to first-line systemic corticosteroid therapy may reduce treatment failure in patients with nonanterior sarcoidosis-associated uveitis.

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Image Credits
Glowing exclamation mark in a neon red warning triangle/© hardvicore / stock.adobe.com / Generated with AI, Doctor examining child in the clinic/© Pixel-Shot / Stock.adobe.com (symbolic image with models), Renal biopsy of patient with thrombocytosis and ANCA-associated vasculitis/© 2025, Andrés Hormaza-Jaramillo et al, BMC Rheumatol, Close up of IV drip bags/© SDI Productions / Getty Images / iStock, 3D render of a human heart overlaid on an ECG graph/© peterschreiber.media / Getty Images / iStock, Lupus concept/© (M) Vitalii But / stock.adobe.com / Generated with AI, Histology of patient with VEXAS syndrome presenting with Sjogren's features/© 2025, Marwin Groener et al, under exclusive licence to International League of Associations for Rheumatology (ILAR), Clin Rheumatol, Woman sweating and clutching chest/© Doucefleur / Getty Images / iStock (symbolic image with model), Medicine Matters Podcast promo image/© Springer Medizin GmbH, Aplastic Anemia/© Springer Healthcare IME, Incretin mimetic injectors/© aprott/ Getty Images / iStock, Scan of toddler’s spine to position the needle for a lumbar sympathetic block to treat complex regional pain syndrome/© 2024, Amany E. Ayad et al, Pain Ther, Woman using a smartphone/© Jajah-sireenut / Getty Images / iStock (symbolic image with model), Man having a coughing episode/© kostyha / stock.adobe.com (symbolic image with model), Stretchy skin in Ehlers-Danlos syndrome/© Biophoto Associates / Science Photo Library, Nervous system illustration/© vefimov / stock.adobe.com (symbolic image with model), Doctor talking to pregnant patient in clinic/© bernardbodo / Getty Images / iStockphoto (symbolic image with models), Vitamin D capsules/© NiseriN / Getty Images / iStock, Weighing scales and measuring tape/© Atlas / stock.adobe.com, Woman doing stretches in bedroom/© Galina Zhigalova / Getty Images / iStock (symbolic image with model), X-rays of patient with heterotopic ossification after wrist replacement/© 2025, Sonja Verena Schmidt et al, J Med Case Reports, Woman taking medication/© ozgurcankaya / Getty Images / iStock (symbolic image with model), Doctor and patient looking at digital tablet/© Felix / peopleimages.com / stock.adobe.com (symbolic image with models), Close-up of gloved hand filling syringe from a vial/© New Africa / stock.adobe.com, Leg ulcers in patient with ulcerative cutaneous sarcoidosis/© 2025, Nabil Belfeki et al, under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature, Rheumatol Int, Skin rash in patient with ALS, CLL, and SLR/© 2025, Joumana Freiha et al, BMC Neurol, 3D render of circulatory system/© magicmine / Stock.adobe.com, Placing a catheter for administering IV drugs/© flywish / stock.adobe.com, ECG during implant demonstrating activation during left branch bundle area pacing/© Hopman et al. BMC Cardiovasc Disord 23, 621 (2023) (CC BY 4.0)