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Psoriasiform eruption in Kawasaki disease

An infant diagnosed with Kawasaki disease developed impetigo-like psoriasiform eruption that was refractory to oral antibiotics and topical steroids and only improved after treatment with oral prednisolone.

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Editor's Choice

Real-world study supports anifrolumab for SLE

Anifrolumab shows a rapid onset of action and clinical benefit in the routine clinical care of patients with systemic lupus erythematosus. 

Treating RA-related interstitial lung disease

Interstitial lung disease is the most severe extra-articular manifestations of rheumatoid arthritis. What is known about its pathogenesis and how does that inform treatment options?

Immunoglobulin A vasculitis and inflammatory bowel disease

IgAV can develop after the diagnosis of IBD, manifesting in the skin, joints, kidneys, and GI tract, but are people with IgAV at risk of IBD? Investigate the interplay between the two, including risk and protective factors.

Atypical presentation of purulent pericardial effusion in SLE patient

A rare case of purulent pericardial effusion secondary to methicillin-sensitive Staphylococcus aureus in a patient with systemic lupus erythematosus that highlights asymptomatic bacteriuria as a potential early indicator.

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Aplastic anemia: managing special patient subgroups and challenging cases (Link opens in a new window)

Learn more about the importance of adapting treatment approaches for special patient populations (eg, elderly or pregnant patients) in this third module of our interactive e-Learning program on diagnosing and treating aplastic anemia.

Independent Medical Education Grant:
  • Pfizer
Learn more

Case Studies

Psoriasiform eruption in Kawasaki disease

An infant diagnosed with Kawasaki disease developed impetigo-like psoriasiform eruption that was refractory to oral antibiotics and topical steroids and only improved after treatment with oral prednisolone.

Atypical presentation of purulent pericardial effusion in SLE patient

A rare case of purulent pericardial effusion secondary to methicillin-sensitive Staphylococcus aureus in a patient with systemic lupus erythematosus that highlights asymptomatic bacteriuria as a potential early indicator.

From infection to infarction: CMV retinitis in JAK inhibition

An 81-year-old receiving upadacitinib for rheumatoid arthritis developed CMV retinitis complicated by delayed retinal ischemia and vitreous hemorrhage. Clinicians should be vigilant for atypical ocular complications from JAK inhibitors.

Episode 24: Looking back at 2025

Advancing patient care

In this special edition of Medicine Matters, we're joined by Dr Gregory Lim, Claire Greenhill, and Sarah Onuora, Chief Editors of Nature Reviews Cardiology, Endocrinology, and Rheumatology, for a look back at the advances in their specialties in 2025.

Find out what caught their attention and why, and what they're looking forward to in 2026.

Gregory Lim
Claire Greenhill
Sarah Onuora
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Podcast

Current Reviews

Early detection and intervention in dermatomyositis: current evidence and clinical implications

Dermatomyositis is a rare autoimmune disease characterized by muscle weakness and distinctive skin rashes. Patients typically present with symmetric proximal muscle weakness alongside extramuscular manifestations, including interstitial lung …

Subchondral bone abnormalities in the knee: imaging techniques, regional anatomy, and pathology

The subchondral bone is an integral structural component of the knee with key roles in shock absorption and load distribution. Injuries to the subchondral bone, which may occur secondary to various etiologies including trauma, degenerative …

Race as a determinant of clinical characteristics, treatments, and outcomes of axial spondyloarthritis in the United States

Axial spondyloarthritis (axSpA) is a chronic, inflammatory, immune-mediated disease characterized by inflammation of the axial skeleton, peripheral joints, and entheses. Patients with axSpA often experience a long diagnostic delay, and if left …

Gastrointestinal adverse events among methotrexate users in rheumatoid arthritis patients: a systematic review and meta-analysis

Methotrexate (MTX) remains the first-line pharmacotherapy for rheumatoid arthritis (RA), yet gastrointestinal (GI) adverse events (AEs) are frequently reported. This systematic review and meta-analysis aimed to estimate the prevalence of GI AEs …

Keynote webinar | Spotlight on advances in lupus

Systemic lupus erythematosus is a severe autoimmune disease that can cause damage to almost every system of the body. Learn more about novel biomarkers for diagnosis and monitoring, and familiarize yourself with current and emerging targeted therapies.

Prof. Edward Vital
Prof. Ronald F. van Vollenhoven
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Video

CME & eLearning

Aplastic anemia (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module eLearning series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

Independent Medical Education Grant:
  • Pfizer

Further Reading

Artificial intelligence on opportunistic computed tomography for predicting vertebral fracture risk in women undergoing estrogen deprivation therapy for breast cancer

Breast cancer (BC) is the most common cancer in women worldwide [ 1 ]. Approximately 80% of BC is hormone receptor positive and may be amenable to hormone deprivation therapies (HDTs), which are usually administered early in the course of the …

Radiomics-based nomogram using digital radiography for early diagnosis of knee osteoarthritis

Knee osteoarthritis (KOA) is a highly prevalent degenerative joint disorder [ 1 ], predominantly affecting middle-aged and elderly individuals, with an estimated global burden of approximately 654 million people [ 2 ]. Clinically, KOA is marked by …

Early detection and intervention in dermatomyositis: current evidence and clinical implications

Dermatomyositis is a rare autoimmune disease characterized by muscle weakness and distinctive skin rashes. Patients typically present with symmetric proximal muscle weakness alongside extramuscular manifestations, including interstitial lung …

Symptomatic Sarcoidosis Treated with Acthar® Gel: Insights from a Physician-Reported Chart Review

Sarcoidosis is a rare, idiopathic, chronic granulomatous disease of unknown cause that primarily affects the lungs in 80–90% of cases [ 1 , 2 ]. The prevalence of sarcoidosis in the United States (U.S.) is estimated to be 60 per 100,000 adults, and …

Related topics

DMARDs boost treatment success in nonanterior sarcoidosis-associated uveitis

Adding a conventional synthetic disease-modifying antirheumatic drug to first-line systemic corticosteroid therapy may reduce treatment failure in patients with nonanterior sarcoidosis-associated uveitis.

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Image Credits
Psoriasiform eruption in infant with Kawasaki disease/© 2026, Yuko Hayashi et al, under exclusive licence to International League of Associations for Rheumatology, Clin Rheumatol, Woman at a medical appointment/© kazuma seki / Getty Images / iStock, Chest scan showing interstitial pulmonary infiltration/© KI-generiert Akmalism / stock.adobe.com, Molecular model of immunoglobulin/© Dr_Microbe / stock.adobe.com, ECG of SLE patient with pericardial effusion/© 2026, Nora Spadoni et al, J Med Case Reports, Aplastic Anemia/© Springer Healthcare IME, Widefield fluorescein angiogram showing retinal ischemia/© 2026, Ciera D. Johnson et al, BMC Ophthalmol, Medicine Matters Podcast promo image/© Springer Medizin GmbH, Lupus concept/© (M) Vitalii But / stock.adobe.com / Generated with AI, Incretin mimetic injectors/© aprott/ Getty Images / iStock, Scan of toddler’s spine to position the needle for a lumbar sympathetic block to treat complex regional pain syndrome/© 2024, Amany E. Ayad et al, Pain Ther, Woman using a smartphone/© Jajah-sireenut / Getty Images / iStock (symbolic image with model), Man having a coughing episode/© kostyha / stock.adobe.com (symbolic image with model), Stretchy skin in Ehlers-Danlos syndrome/© Biophoto Associates / Science Photo Library, Nervous system illustration/© vefimov / stock.adobe.com (symbolic image with model), Close-up of man with both hands on knee/© Jacob Wackerhausen / Getty Images / iStock, Close-up of person massaging their hand/© Jacob Wackerhausen / Getty Images / iStock, Vitamin D capsules/© NiseriN / Getty Images / iStock, Weighing scales and measuring tape/© Atlas / stock.adobe.com, Woman doing stretches in bedroom/© Galina Zhigalova / Getty Images / iStock (symbolic image with model), X-rays of patient with heterotopic ossification after wrist replacement/© 2025, Sonja Verena Schmidt et al, J Med Case Reports, Close-up of gloved hand filling syringe from a vial/© New Africa / stock.adobe.com, Leg ulcers in patient with ulcerative cutaneous sarcoidosis/© 2025, Nabil Belfeki et al, under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature, Rheumatol Int, Skin rash in patient with ALS, CLL, and SLR/© 2025, Joumana Freiha et al, BMC Neurol, 3D render of circulatory system/© magicmine / Stock.adobe.com, Placing a catheter for administering IV drugs/© flywish / stock.adobe.com, ECG during implant demonstrating activation during left branch bundle area pacing/© Hopman et al. BMC Cardiovasc Disord 23, 621 (2023) (CC BY 4.0)