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Open Access 01-02-2025 | Rheumatoid Arthritis | Systematic Review

The global prevalence of interstitial lung disease in patients with rheumatoid arthritis: a systematic review and meta-analysis

Authors: Hari Prasanna, Charles A. Inderjeeth, Johannes C. Nossent, Khalid B. Almutairi

Published in: Rheumatology International | Issue 2/2025

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Abstract

This study aims to review the literature and estimate the global pooled prevalence of interstitial lung disease among patients with rheumatoid arthritis (RA-ILD). The influence of risk factors like geography, socioeconomic status, smoking and DMARD use will be explored. A systematic review was performed according to the PRISMA and JBI guidelines. Studies published between January 1980 and February 2024 were sourced from 7 electronic databases and screened for eligibility. A random-effects meta-analysis model was used to produce pooled prevalences and the potential between-study heterogeneity was identified using sensitivity, subgroup, meta-regression and correlation analyses. 33 studies were included in this meta-analysis containing 14,281 RA patients. The global pooled prevalence of RA-ILD was 21.38% (CI: 0.1542–0.2886), with a high heterogeneity (I2) of 98%. The prevalence of usual interstitial pneumonia and non-specific interstitial pneumonia among RA patients were 11.01% and 6.86% respectively. Africa had the highest RA-ILD prevalence with an imprecise estimate of 38.15% (95% Confidence Interval [CI]: 2.29–94.2) and Europe had the lowest prevalence of 10.15% (CI: 2.86–30.23). Other risk factors associated with a higher prevalence of RA-ILD included living in low-income countries, smoking and DMARD use. The biggest limitation of this study is the high heterogeneity of results and underrepresentation of Oceania and low-income countries. This study has clarified the global prevalence of RA-ILD. The risk factors identified in this study can aid clinicians in identifying high-risk populations and highlight the need for screening these populations. Smoking cessation should also be encouraged.
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Literature
4.
go back to reference Antoine MH, Mlika M (2024) Interstitial lung disease. StatPearls. Treasure Island (FL) Antoine MH, Mlika M (2024) Interstitial lung disease. StatPearls. Treasure Island (FL)
6.
go back to reference Agarwal AK, Huda N (2024) Interstitial pulmonary fibrosis. StatPearls. Treasure Island (FL) Agarwal AK, Huda N (2024) Interstitial pulmonary fibrosis. StatPearls. Treasure Island (FL)
14.
17.
go back to reference Nayfeh AS, Chippa V, Moore DR (2024) Nonspecific interstitial pneumonia. StatPearls. Treasure Island (FL) Nayfeh AS, Chippa V, Moore DR (2024) Nonspecific interstitial pneumonia. StatPearls. Treasure Island (FL)
18.
go back to reference American Thoracic S, European Respiratory S, American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias (2002) This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 165(2):277–304. https://doi.org/10.1164/ajrccm.165.2.ats01CrossRef American Thoracic S, European Respiratory S, American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias (2002) This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 165(2):277–304. https://​doi.​org/​10.​1164/​ajrccm.​165.​2.​ats01CrossRef
25.
go back to reference Kasturi S, Goldstein BL, Malspeis S, Karlson EW, Costenbader KH (2014) Comparison of the 1987 American College of Rheumatology and the 2010 American College of Rheumatology/European League against Rheumatism criteria for classification of rheumatoid arthritis in the nurses’ Health Study cohorts. Rheumatol Int 34(3):407–411. https://doi.org/10.1007/s00296-013-2865-2CrossRefPubMed Kasturi S, Goldstein BL, Malspeis S, Karlson EW, Costenbader KH (2014) Comparison of the 1987 American College of Rheumatology and the 2010 American College of Rheumatology/European League against Rheumatism criteria for classification of rheumatoid arthritis in the nurses’ Health Study cohorts. Rheumatol Int 34(3):407–411. https://​doi.​org/​10.​1007/​s00296-013-2865-2CrossRefPubMed
29.
go back to reference Harrer M, Cuijpers P, Furukawa TA, Ebert DD (2021) Doing Meta-Analysis With R: A Hands-On Guide. 1st ed. Boca Raton, FL and London: Chapman & Hall/CRC Press; 2021 Harrer M, Cuijpers P, Furukawa TA, Ebert DD (2021) Doing Meta-Analysis With R: A Hands-On Guide. 1st ed. Boca Raton, FL and London: Chapman & Hall/CRC Press; 2021
34.
go back to reference Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50(4):1088–1101CrossRefPubMed Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50(4):1088–1101CrossRefPubMed
36.
72.
go back to reference Samhouri BF, Vassallo R, Achenbach SJ, Kronzer VL, Davis JM 3rd, Myasoedova E et al (2022) Incidence, risk factors, and Mortality of Clinical and Subclinical Rheumatoid Arthritis-Associated interstitial lung disease: a Population-based cohort. Arthritis Care Res (Hoboken) 74(12):2042–2049. https://doi.org/10.1002/acr.24856 Samhouri BF, Vassallo R, Achenbach SJ, Kronzer VL, Davis JM 3rd, Myasoedova E et al (2022) Incidence, risk factors, and Mortality of Clinical and Subclinical Rheumatoid Arthritis-Associated interstitial lung disease: a Population-based cohort. Arthritis Care Res (Hoboken) 74(12):2042–2049. https://​doi.​org/​10.​1002/​acr.​24856
Metadata
Title
The global prevalence of interstitial lung disease in patients with rheumatoid arthritis: a systematic review and meta-analysis
Authors
Hari Prasanna
Charles A. Inderjeeth
Johannes C. Nossent
Khalid B. Almutairi
Publication date
01-02-2025
Publisher
Springer Berlin Heidelberg
Published in
Rheumatology International / Issue 2/2025
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-025-05789-4

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