Computed tomography-based quantitative scoring system for rheumatoid arthritis–associated interstitial lung disease: a retrospective diagnostic accuracy study for progressive fibrosis detection

To investigate the ability of quantitative parameters to assess the severity of rheumatoid arthritis (RA)–associated interstitial lung disease (ILD).

Thorax CT images and pulmonary function tests of RA patients followed up in a tertiary reference center were retrospectively examined. Radiologically, patients were divided into two groups as limited and extensive ILD, using two semiquantitative scoring systems. Two different methods (Method 1, Method 2) were used for quantitative image analysis, in which different Hounsfield unit values were selected as thresholds. Spearman’s correlation test was used to evaluate the relationship between variables. The diagnostic performance of quantitative methods for the ability to distinguish limited ILD from extensive ILD was calculated using ROC analysis.

This study demonstrates that quantitative methods (Method 1 [− 700 to − 200 HU] and Method 2 [− 800 to − 500 HU]) play a significant role in assessing the severity of RA-associated ILD (RA-ILD). Both methods showed significant correlations with pulmonary function tests (DLCO [r₁ = − 0.338, p₁ = 0.025; r₂ = − 0.452, p₂ = 0.002] and TLC [r₁ = − 0.567, p₁ < 0.001; r₂ = − 0.576, p₂ < 0.001), with Method 1 (AUC_ILD = 0.945 and AUC_MCRD = 0.911) demonstrating superior performance in distinguishing between limited and extensive ILD. Our findings suggest that Hounsfield unit threshold–based quantitative CT analysis may serve as a more objective and reproducible alternative to semiquantitative systems (e.g., Goh score) in the standard evaluation of RA-ILD. Specifically, Method 1 may enable early detection of progression by mechanism, e.g., “tracking subtle density changes.” However, further validation in multicenter prospective cohorts is needed to address limitations such as bias.