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Current Cardiology Reports

Cardiovascular Risk Factor and Atherosclerosis in Rheumatoid Arthritis (RA)

Published in:
Authors
Lakshmi Kattamuri
Shivangini Duggal
John Paul Aparece
Shrilekha Sairam
Published in
Current Cardiology Reports | Issue 1/2025

Abstract

Purpose of Review

To highlight advancements in managing traditional and rheumatoid arthritis (RA) specific risk factors and the impact of RA treatments on cardiovascular outcomes.

Recent Findings

Advancements in rheumatoid arthritis management have paralleled declining trends in cardiovascular disease risks. Biomarkers like CRP, Lipoprotein(a), Apolipoprotein B 100, and imaging tools such as coronary artery calcium scoring enhance cardiovascular risk stratification, particularly in intermediate-risk RA patients. While effective RA treatments, have demonstrated substantial cardiovascular benefits, subclass differences were noted in high-risk patients.

Summary

Increased risk of cardiovascular disease is driven by chronic inflammation, altered lipid metabolism, and traditional risk factors. Effective RA treatment significantly lowers cardiovascular events. Standard treatment of hypertension, diabetes and hypercholesterolemia are effective and lowers RA disease activity and inflammatory markers. While RA is considered a risk enhancing state in calculating CV risk scores, currently there exists no RA disease -specific blood pressure, blood sugar or lipid targets.
Title
Cardiovascular Risk Factor and Atherosclerosis in Rheumatoid Arthritis (RA)
Authors
Lakshmi Kattamuri
Shivangini Duggal
John Paul Aparece
Shrilekha Sairam
Publication date
01-12-2025
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 1/2025
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-025-02198-8
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This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
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Learn more Link opens in a new window
Image Credits
Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME