Background
Early cardiac damage is very common in RA patients, but it is usually subclinical. Therefore, finding a non-invasive method for the early detection and treatment of cardiac damage in autoimmune diseases is particularly important.早期diac dam年龄在 RA 患者中很常见，但通常是亚临床的。因此，寻找一种非侵入性方法来早期检测和治疗自身免疫性疾病中的心脏损伤尤为重要。
Objective
To evaluate left ventricular function changes in rheumatoid arthritis (RA) patients with preserved left ventricular ejection fraction (LVEF) using left ventricular pressure-strain loop (LV-PSL) technology and to explore the correlation between myocardial work (MW) and disease activity.使用左心室压力-应变环 （LV-PSL） 技术评估左心室射血分数 （LVEF） 保留的类风湿性关节炎 （RA） 患者的左心室功能变化，并探讨心肌功 （MW） 与疾病活动度之间的相关性。
Methods
A total of 62 RA patients with preserved LVEF, treated at Wujin Hospital Affiliated with Jiangsu University from January 2021 to September 2023, were included. Patients were categorized into low (25), medium (18), and high (19) disease activity groups based on the 28 joint disease activity score (DAS28). A control group of 29 healthy individuals was also established. LV-PSL technology assessed left ventricular global longitudinal strain (GLS) and MW parameters: global constructive work (GCW), global wasted work (GWW), global work index (GWI), and global work efficiency (GWE). Correlations between MW parameters, GLS, LVEF, and DAS28 scores were analyzed.共纳入 2021 年 1 月至 2023年9月在江苏大学附属武进医院治疗的 62 例 LVEF 保留的 RA 患者。根据 28 项关节疾病活动评分 （DAS28） 将患者分为低 （25） 、中 （18） 和高 （19） 疾病活动组。还建立了一个由 29 名健康个体组成的对照组。LV-PSL 技术评估左心室整体纵向应变 （GLS） 和 MW 参数：整体建设性工作 （GCW）、整体浪费工作 （GWW）、整体工作指数 （GWI） 和整体工作效率 （GWE）。分析 MW 参数、 GLS 、 LVEF 和 DAS28 评分之间的相关性。
Results
There were no significant differences in general data between study and control groups (p > 0.05). However, laboratory indicators (RF, CRP, ESR) showed significant differences (p < 0.05). GWI, GCW, GWE, and GLS were significantly lower in the high disease activity group compared to controls (p < 0.05). GWI, GCW, and GWE were positively correlated with LVEF and absolute GLS, while GWW correlated negatively with LVEF (p < 0.05).研究组和对照组之间的一般数据没有显著差异 （p > 0.05）。然而，实验室指标 （RF、CRP、ESR） 显示显着差异 （p < 0.05）。与对照组相比，高疾病活动组的 GWI、GCW、GWE 和 GLS 显着降低 （p < 0.05）。GWI、GCW 和 GWE 与 LVEF 和绝对 GLS 呈正相关，而 GWW 与 LVEF 呈负相关 （p < 0.05）。研究组和对照组之间的一般数据没有显著差异 （p > 0.05）。然而，实验室指标 （RF、CRP、ESR） 显示显着差异 （p < 0.05）。与对照组相比，高疾病活动组的 GWI、GCW、GWE 和 GLS 显着降低 （p < 0.05）。GWI、GCW 和 GWE 与 LVEF 和绝对 GLS 呈正相关，而 GWW 与 LVEF 呈负相关 （p < 0.05）。
Conclusion
RA disease activity is closely associated with impaired myocardial work. LV-PSL technology effectively monitors myocardial function abnormalities in RA patients, providing valuable insights for clinical management.
Key Points • Myocardial work is significantly impaired in RA patients with high disease activity. • Left ventricular pressure-strain loop (LV-PSL) technology effectively assesses cardiac function in this patient population. • Increased disease activity correlates with reduced myocardial work parameters. |
