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Published in: International Ophthalmology 5/2022

21-03-2022 | Retinal Detachment | Review

Efficacy of prophylactic laser retinopexy in acute retinal necrosis: A systematic review and meta-analysis

Authors: Shipei Fan, Dan Lin, Ronghan Wu, Yuqin Wang

Published in: International Ophthalmology | Issue 5/2022

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Abstract

Purpose

We performed a systematic review and meta-analysis to assess the role of prophylactic laser retinopexy in preventing rhegmatogenous retinal detachment (RRD) in acute retinal necrosis (ARN).

Methods

Pubmed, Embase and Cochrane databases were searched for eligible studies from inception to July 2020. Comprehensive clinical demographics were extracted from each study by two independent investigators. A random effects model was selected to analyze the OR of RRD risk and visual outcome with 95%CI. Subsequent subgroup and sensitivity analysis were conducted to evaluate the source of heterogeneity.

Results

A total of eight studies and 247 eyes (111 prophylactic laser retinopexy eyes and 136 eyes receiving antiviral treatment) were included in this analysis. There was moderate statistical heterogeneity across all studies. When compared with routine antiviral treatment alone, RRD risk decreased in patients receiving prophylactic laser retinopexy, however, this was not statistically significant (P = 0.09, OR = 0.42, 95%CI: 0.15–1.15). There was significant improvement in BCVA during the follow-up period in the prophylactic laser retinopexy subgroup (P = 0.01, WMD = − 0.98, 95%CI: − 1.74, − 0.22).

Conclusion

Based on current analysis, our results did not support convincing evidence of prophylactic laser in preventing RRD. Future studies featuring high-quality, multicenter trials will be required to correct baseline characteristics.

Trial registration

This meta-analysis has been retrospectively registered in Prospero (registration number: CRD42020201008).
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Literature
11.
go back to reference Chen HP, Kuo HK, Tsai SH, Chen YJ, Kao ML (2004) Acute retinal necrosis syndrome: clinical manifestations and visual outcomes. Chang Gung Med J 27:193–200PubMed Chen HP, Kuo HK, Tsai SH, Chen YJ, Kao ML (2004) Acute retinal necrosis syndrome: clinical manifestations and visual outcomes. Chang Gung Med J 27:193–200PubMed
29.
go back to reference Flaxel CJ, Yeh S, Lauer AK (2013) Combination systemic and intravitreal antiviral therapy in the management of acute retinal necrosis syndrome (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc 111:133–144PubMedPubMedCentral Flaxel CJ, Yeh S, Lauer AK (2013) Combination systemic and intravitreal antiviral therapy in the management of acute retinal necrosis syndrome (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc 111:133–144PubMedPubMedCentral
Metadata
Title
Efficacy of prophylactic laser retinopexy in acute retinal necrosis: A systematic review and meta-analysis
Authors
Shipei Fan
Dan Lin
Ronghan Wu
Yuqin Wang
Publication date
21-03-2022
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 5/2022
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-021-02131-2

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