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Published in: Ophthalmology and Therapy 5/2023

Open Access 08-07-2023 | Retinal Detachment | ORIGINAL RESEARCH

Multimodal Analysis on Clinical Characteristics of the Advanced Stage in Myopic Traction Maculopathy

Authors: Jiaxin Tian, Caixia Lin, Yuxin Fang, Kai Cao, Anli Duan, Yue Qi, Ningli Wang

Published in: Ophthalmology and Therapy | Issue 5/2023

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Abstract

Introduction

Here we investigate the clinical features of foveal detachment (FD), full-thickness macular hole (MH), and macular hole retinal detachment (MHRD) in myopic traction maculopathy (MTM).

Methods

In the retrospective observational case series, 314 eyes of 198 patients with myopic retinoschisis in Beijing Tongren Hospital were enrolled. We recorded gender, age, and axial length and evaluated fundus characteristics using optical coherence tomography. Epiretinal membranes (ERMs), vitreoretinal traction, and paravascular abnormalities (PVAs) were used to describe the vitreoretinal interface condition. Different retinoschisis layers (inner, middle, and outer retinoschisis) and the location with a range of outer retinoschisis were evaluated to reveal the retinal condition. Five patterns of the scleral shape: dome-shaped, sloped toward the optic nerve, symmetrical or asymmetrical around the fovea, and irregular were assessed to show retina-sclera condition. We regarded the FD, full-thickness MH, and MHRD as the advanced stage in MTM. Multivariate logistic regression assessed significant factors for the advanced stage with odds ratios (OR) and 95% confidence intervals (CI).

Results

There were 76 eyes with FD, 6 eyes with full-thickness MH, and 7 eyes with MHRD. The mean age was 52.9 ± 12.3 years. On univariate analysis, the eyes with the advanced stage were older and had higher rates of ERMs, PVAs, middle retinoschisis, outer retinoschisis, and irregular sclera shape. The number of retinoschisis layers and the grade of outer retinoschisis were higher in eyes with the advanced stage. After multivariate logistic regression, ERMs (OR 1.983; 95% CI 1.093–3.595; P = 0.024), middle retinoschisis (OR 2.967; 95% CI 1.630–5.401; P < 0.001), and higher grades of outer retinoschisis (OR 2.227; 95% CI 1.711–2.898; P < 0.001) remained associated with the advanced stage.

Conclusion

ERMs, middle retinoschisis, and more extensive outer retinoschisis were significant characteristics of the advanced stage in MTM.
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Metadata
Title
Multimodal Analysis on Clinical Characteristics of the Advanced Stage in Myopic Traction Maculopathy
Authors
Jiaxin Tian
Caixia Lin
Yuxin Fang
Kai Cao
Anli Duan
Yue Qi
Ningli Wang
Publication date
08-07-2023
Publisher
Springer Healthcare
Published in
Ophthalmology and Therapy / Issue 5/2023
Print ISSN: 2193-8245
Electronic ISSN: 2193-6528
DOI
https://doi.org/10.1007/s40123-023-00745-6

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