Top

Published in:

Open Access 01-12-2023 | Respiratory Microbiota | Review

Recent five-year progress in the impact of gut microbiota on vaccination and possible mechanisms

Authors: Biqing Huang, Jianwei Wang, Lanjuan Li

Published in: Gut Pathogens | Issue 1/2023

Abstract

Vaccine is the most effective way to prevent the spread of communicable diseases, but the immune response induced by it varies greatly between individuals and populations in different regions of the world. Current studies have identified the composition and function of the gut microbiota as key factors in modulating the immune response to vaccination. This article mainly reviews the differences in gut microbiota among different groups of vaccinated people and animals, explores the possible mechanism of vaccine immunity affected by gut microbiota, and reviews the strategies for targeting gut microbiota to improve vaccine efficacy.

Lynn DJ, Benson SC, Lynn MA, et al. Modulation of immune responses to vaccination by the microbiota: implications and potential mechanisms[J]. Nat Rev Immunol. 2022;22(1):33–46. https://doi.org/10.1038/s41577-021-00554-7. PubMed 34002068.CrossRefPubMed

de Jong SE, Olin A, Pulendran B. The impact of the Microbiome on immunity to vaccination in Humans[J]. Cell Host Microbe. 2020;28(2):169–79. https://doi.org/10.1016/j.chom.2020.06.014.CrossRefPubMedPubMedCentral

Jordan A, Carding SR, Hall LJ. The early-life gut microbiome and vaccine efficacy[J]. Lancet Microbe. 2022;3(10):e787–94. https://doi.org/10.1016/s2666-5247(22)00185-9. PubMed 36088916.CrossRefPubMed

Swaminathan G, Citron M, Xiao J, et al. Vaccine Hyporesponse Induced by Individual Antibiotic Treatment in mice and non-human Primates is diminished upon recovery of the gut Microbiome[J]. Vaccines (Basel). 2021;9(11). https://doi.org/10.3390/vaccines9111340. PubMed 34835271.

Lynn MA, Tumes DJ, Choo JM, et al. Early-Life Antibiotic-Driven Dysbiosis leads to Dysregulated Vaccine Immune responses in Mice[J]. Cell Host Microbe. 2018;23(5):653–660e655. https://doi.org/10.1016/j.chom.2018.04.009. PubMed 29746836.CrossRefPubMed

Yitbarek A, Astill J, Hodgins DC, et al. Commensal gut microbiota can modulate adaptive immune responses in chickens vaccinated with whole inactivated avian influenza virus subtype H9N2[J]. Vaccine. 2019;37(44):6640–7. https://doi.org/10.1016/j.vaccine.2019.09.046. PubMed 31542262.CrossRefPubMed

Nadeem S, Maurya SK, Das DK, et al. Gut dysbiosis thwarts the efficacy of Vaccine against Mycobacterium tuberculosis[J]. Front Immunol. 2020;11:726. https://doi.org/10.3389/fimmu.2020.00726. PubMed 32508806.CrossRefPubMedPubMedCentral

Stedman A, Maluquer de Motes C, Lesellier S, et al. Lactic acid Bacteria isolated from european badgers (Meles meles) reduce the viability and survival of Bacillus Calmette-Guerin (BCG) vaccine and influence the immune response to BCG in a human macrophage model[J]. BMC Microbiol. 2018;18(1):74. https://doi.org/10.1186/s12866-018-1210-z. PubMed 30005620.CrossRefPubMedPubMedCentral

Zhang Y, Wu Q, Zhou M, et al. Composition of the murine gut microbiome impacts humoral immunity induced by rabies vaccines[J]. Clin Transl Med. 2020;10(4):e161. https://doi.org/10.1002/ctm2.161. PubMed 32898335.CrossRefPubMedPubMedCentral

10.

Harris VC, Armah G, Fuentes S, et al. Significant correlation between the infant gut microbiome and Rotavirus Vaccine Response in Rural Ghana[J]. J Infect Dis. 2017;215(1):34–41. https://doi.org/10.1093/infdis/jiw518. PubMed 27803175.CrossRefPubMed

11.

Harris V, Ali A, Fuentes S, et al. Rotavirus vaccine response correlates with the infant gut microbiota composition in Pakistan[J]. Gut Microbes. 2018;9(2):93–101. PubMed 28891751.CrossRefPubMed

12.

Kim AH, Armah G, Dennis F, et al. Enteric virome negatively affects seroconversion following oral rotavirus vaccination in a longitudinally sampled cohort of ghanaian infants[J]. Cell Host Microbe. 2022;30(1):110–123e115. https://doi.org/10.1016/j.chom.2021.12.002. PubMed 34932985.CrossRefPubMedPubMedCentral

13.

Parker EPK, Bronowski C, Sindhu KNC, et al. Impact of maternal antibodies and microbiota development on the immunogenicity of oral rotavirus vaccine in African, Indian, and european infants[J]. Nat Commun. 2021;12(1):7288. https://doi.org/10.1038/s41467-021-27074-1. PubMed 34911947.CrossRefPubMedPubMedCentral

14.

Fix J, Chandrashekhar K, Perez J, et al. Association between Gut Microbiome Composition and Rotavirus Vaccine response among nicaraguan Infants[J]. Am J Trop Med Hyg. 2020;102(1):213–9. https://doi.org/10.4269/ajtmh.19-0355. PubMed 31802728.CrossRefPubMed

15.

Robertson RC, Church JA, Edens TJ, et al. The fecal microbiome and rotavirus vaccine immunogenicity in rural zimbabwean infants[J]. Vaccine. 2021;39(38):5391–400. https://doi.org/10.1016/j.vaccine.2021.07.076. PubMed 34393020.CrossRefPubMedPubMedCentral

16.

Huda MN, Ahmad SM, Alam MJ, et al. Bifidobacterium abundance in early infancy and vaccine response at 2 years of Age[J]. Pediatrics. 2019;143(2). https://doi.org/10.1542/peds.2018-1489. PubMed 30674610.

17.

Moroishi Y, Gui J, Nadeau KC, et al. A prospective study of the infant gut microbiome in relation to vaccine response[J]. Pediatr Res. 2022. https://doi.org/10.1038/s41390-022-02154-0. PubMed 35717483.CrossRefPubMedPubMedCentral

18.

Ng SC, Peng Y, Zhang L, et al. Gut microbiota composition is associated with SARS-CoV-2 vaccine immunogenicity and adverse events[J]. Gut. 2022;71(6):1106–16. https://doi.org/10.1136/gutjnl-2021-326563. PubMed 35140064.CrossRefPubMed

19.

Tang B, Tang L, He W, et al. Correlation of gut microbiota and metabolic functions with the antibody response to the BBIBP-CorV vaccine[J]. Cell Rep Med. 2022;3(10):100752. https://doi.org/10.1016/j.xcrm.2022.100752. PubMed 36228621.CrossRefPubMedPubMedCentral

20.

Gonçalves JIB, Borges TJ, de Souza APD. Microbiota and the response to vaccines against respiratory Virus[J]. Front Immunol. 2022;13:889945. https://doi.org/10.3389/fimmu.2022.889945. PubMed 35603203.CrossRefPubMedPubMedCentral

21.

Oh JZ, Ravindran R, Chassaing B, et al. TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination[J]. Immunity. 2014;41(3):478–92.CrossRefPubMedPubMedCentral

22.

Chac D, Bhuiyan TR, Saha A, et al. Gut microbiota and development of Vibrio cholerae-specific long-term memory B cells in adults after whole-cell killed oral Cholera Vaccine[J]. Infect Immun. 2021;89(9):e0021721. https://doi.org/10.1128/iai.00217-21. PubMed 34228490.CrossRefPubMed

23.

Stražar M, Mourits VP, Koeken V, et al. The influence of the gut microbiome on BCG-induced trained immunity[J]. Genome Biol. 2021;22(1):275. https://doi.org/10.1186/s13059-021-02482-0. PubMed 34551799.CrossRefPubMedPubMedCentral

24.

Abt MC, Osborne LC, Monticelli LA, et al. Commensal bacteria calibrate the activation threshold of innate antiviral immunity[J]. Immunity. 2012;37(1):158–70. https://doi.org/10.1016/j.immuni.2012.04.011.CrossRefPubMedPubMedCentral

25.

Wang B, Zhang L, Wang Y, et al. Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions[J]. Signal Transduct Target Ther. 2022;7(1):143. https://doi.org/10.1038/s41392-022-00986-0. PubMed 35487886.CrossRefPubMedPubMedCentral

26.

Silva F, Enaud R, Creissen E, et al. Mouse subcutaneous BCG vaccination and Mycobacterium tuberculosis infection alter the lung and gut Microbiota[J]. Microbiol Spectr. 2022;10(3):e0169321. https://doi.org/10.1128/spectrum.01693-21. PubMed 35652642.CrossRefPubMed

27.

Macpherson AJ. Do the Microbiota influence vaccines and protective immunity to pathogens? Issues of Sovereignty, Federalism, and points-testing in the prokaryotic and eukaryotic spaces of the host-microbial Superorganism[J]. Cold Spring Harb Perspect Biol. 2018;10(2). https://doi.org/10.1101/cshperspect.a029363. PubMed 28432128.

28.

Littman DR. Do the Microbiota influence vaccines and protective immunity to pathogens? If so, is there potential for efficacious microbiota-based vaccines?[J]. Cold Spring Harb Perspect Biol. 2018;10(2). https://doi.org/10.1101/cshperspect.a029355. PubMed 28432131.

29.

Williams WB, Liao HX, Moody MA, et al. HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies[J]. Science. 2015;349(6249):aab1253. https://doi.org/10.1126/science.aab1253. PubMed 26229114.CrossRefPubMedPubMedCentral

30.

Jia L, Weng S, Wu J, et al. Preexisting antibodies targeting SARS-CoV-2 S2 cross-react with commensal gut bacteria and impact COVID-19 vaccine induced immunity[J]. Gut Microbes. 2022;14(1):2117503. https://doi.org/10.1080/19490976.2022.2117503. PubMed 36100957.CrossRefPubMedPubMedCentral

31.

Harris VC, Haak BW, Handley SA, et al. Effect of antibiotic-mediated Microbiome Modulation on Rotavirus Vaccine Immunogenicity: A Human, Randomized-Control Proof-of-Concept Trial[J]. Cell Host Microbe. 2018;24(2):197–207e194. https://doi.org/10.1016/j.chom.2018.07.005. PubMed 30092197.CrossRefPubMed

32.

Xu J, Ren Z, Cao K, et al. Boosting vaccine-elicited respiratory mucosal and systemic COVID-19 immunity in mice with the oral Lactobacillus plantarum[J]. Front Nutr. 2021;8:789242. https://doi.org/10.3389/fnut.2021.789242. PubMed 35004816.CrossRefPubMedPubMedCentral

33.

Lee JE, Kye YC, Park SM, et al. Bacillus subtilis spores as adjuvants against avian influenza H9N2 induce antigen-specific antibody and T cell responses in White Leghorn chickens[J]. Vet Res. 2020;51(1):68. https://doi.org/10.1186/s13567-020-00788-8. PubMed 32448402.CrossRefPubMedPubMedCentral

34.

Cai H, Luo S, Zhou Q, et al. Effects of Bacillus subtilis and coccidiosis vaccine on growth indices and intestinal microbiota of broilers[J]. Poult Sci. 2022;101(11):102091. https://doi.org/10.1016/j.psj.2022.102091. PubMed 36095864.CrossRefPubMedPubMedCentral

35.

Mezhenskaya D, Isakova-Sivak I, Gupalova T, et al. A live probiotic vaccine prototype based on conserved Influenza a Virus Antigens protect mice against Lethal Influenza Virus Infection[J]. Biomedicines. 2021;9(11). https://doi.org/10.3390/biomedicines9111515. PubMed 34829744.

36.

Mullié C, Yazourh A, Thibault H, et al. Increased poliovirus-specific intestinal antibody response coincides with promotion of Bifidobacterium longum-infantis and Bifidobacterium breve in infants: a randomized, double-blind, placebo-controlled trial[J]. Pediatr Res. 2004;56(5):791–5. https://doi.org/10.1203/01.Pdr.0000141955.47550.A0.CrossRefPubMed

37.

Sandionigi A, De Giani A, Tursi F, et al. Effectiveness of Multistrain Probiotic Formulation on common infectious disease symptoms and gut microbiota modulation in Flu-Vaccinated Healthy Elderly Subjects[J]. Biomed Res Int. 2022;2022:3860896. https://doi.org/10.1155/2022/3860896. PubMed 35127941.CrossRefPubMedPubMedCentral

38.

van den Elsen LWJ, Tims S, Jones AM, et al. Prebiotic oligosaccharides in early life alter gut microbiome development in male mice while supporting influenza vaccination responses[J]. Benef Microbes. 2019;10(3):279–91. https://doi.org/10.3920/bm2018.0098. PubMed 30773928.CrossRefPubMed

39.

Taghinezhad SS, Keyvani H, Bermúdez-Humarán LG, et al. Twenty years of research on HPV vaccines based on genetically modified lactic acid bacteria: an overview on the gut-vagina axis[J]. Cell Mol Life Sci. 2021;78(4):1191–206. https://doi.org/10.1007/s00018-020-03652-2. PubMed 32979054.CrossRef

Title: Recent five-year progress in the impact of gut microbiota on vaccination and possible mechanisms
Authors: Biqing Huang
Jianwei Wang
Lanjuan Li
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Respiratory Microbiota
Vaccination
Published in: Gut Pathogens / Issue 1/2023
Electronic ISSN: 1757-4749
DOI: https://doi.org/10.1186/s13099-023-00547-y

EASD 2024

‘Noninferior’ reduction of type 1 diabetes HbA1c by weekly insulin efsitora alfa

12-09-2024
Type 1 Diabetes
News

Weekly treatment with insulin efsitora is noninferior to daily insulin degludec for the reduction of HbA1c in adults with type 1 diabetes, show the findings of the QWINT-5 trial.

12-09-2024
Obesity
News

Tirzepatide significantly reduces UACR in individuals with obesity and type 2 diabetes

12-09-2024
Type 2 Diabetes
News

Liraglutide reduces BMI for young children with obesity

11-09-2024
Pediatric Obesity
News

» View more highlights on the EASD 2024 hub page

2024 ESC Congress

Noise pollution dangerous for heart health

02-09-2024
Myocardial Infarction
News

Two studies underscore the adverse impact of noise pollution on the risk for and prognosis after myocardial infarction.

Antihypertensives: more effective at morning or night?

02-09-2024
Hypertension
News

Low Lp(a) levels unlikely to increase the risk of diabetes

02-09-2024
Type 2 Diabetes
News

» View more highlights on the 2024 ESC Congress hub page

A quick guide to ECGs

Electrocardiography
Training Course

Improve your ECG interpretation skills with this comprehensive, rapid, interactive course. Expert advice provides detailed feedback as you work through 50 ECGs covering the most common cardiac presentations to ensure your practice stays up to date.

PD Dr. Carsten W. Israel

Developed by: Springer Medizin

Start the cases

At a glance: The STEP trials

Obesity
Clinical Trial Summary

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Keynote webinar | Spotlight on modern management of frailty

Springer Medicine

Recent five-year progress in the impact of gut microbiota on vaccination and possible mechanisms

Abstract

EASD 2024

‘Noninferior’ reduction of type 1 diabetes HbA1c by weekly insulin efsitora alfa

Weight loss with new obesity drug amycretin

Tirzepatide significantly reduces UACR in individuals with obesity and type 2 diabetes

Liraglutide reduces BMI for young children with obesity

» View more highlights on the EASD 2024 hub page

2024 ESC Congress

Noise pollution dangerous for heart health

Post-TAVI follow up: deploying virtual assistants

Antihypertensives: more effective at morning or night?

Low Lp(a) levels unlikely to increase the risk of diabetes

» View more highlights on the 2024 ESC Congress hub page

A quick guide to ECGs

At a glance: The STEP trials

Keynote webinar | Spotlight on modern management of frailty

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2023

miR-125a-5p regulates the sialyltransferase ST3GAL1 in murine model of human intestinal campylobacteriosis

Production of highly immunogenic and safe Triton X-100 produced bacterial ghost vaccine against Shigella flexneri 2b serotype

Invasion of intestinal cells by Staphylococcus warneri, a member of the human gut microbiota

Single-cell RNA sequencing reveals the mediatory role of cancer-associated fibroblast PTN in hepatitis B virus cirrhosis-HCC progression

Establishment of persistent enteric mycobacterial infection following streptomycin pre-treatment

Intravenous antibiotics in preterm infants have a negative effect upon microbiome development throughout preterm life

EASD 2024

2024 ESC Congress