A Scoping Review on the Role of the Microbiome as a Factor in the Bidirectional Association Between Obesity and Depression
- 01-12-2025
- Respiratory Microbiota
- REVIEW
Published in:
- Authors
- Gabrielle Beswick
- Nicole Major
- Cleo Hendrickson
- Vivek Kumar
- Madi Waller
- Zuha Durrani
- Sophie Hotchkiss
- Asem Bala
- Valerie H. Taylor
- Published in
- Current Diabetes Reports | Issue 1/2025
Abstract
Purpose of Review
Obesity is a chronic illness highly comorbid with mental health conditions, particularly depression. Among the factors involved in this association, inflammation is a consistently identified link. This review explores the emerging role of the gut microbiota as a modulator of inflammation and its potential involvement in the pathophysiological processes linking obesity and depression.
Recent Findings
Chronic low-grade inflammation is observed in both obesity and depressive disorders. Alterations in gut microbiota are increasingly implicated in inflammatory mechanisms, including increased intestinal permeability, immune activation, and short-chain fatty acid (SCFA) production, influencing leukocyte function and cytokine production. Additionally, both obesity and depression are associated with altered microbial composition.
Summary
The gut microbiome contributes to chronic inflammation relevant to the pathophysiology of both obesity and depression. Accumulating evidence highlights the need for further research into how gut microbiota influences inflammatory mechanisms observed in both obesity and depression.
Advertisement
- Title
- A Scoping Review on the Role of the Microbiome as a Factor in the Bidirectional Association Between Obesity and Depression
- Authors
-
Gabrielle Beswick
Nicole Major
Cleo Hendrickson
Vivek Kumar
Madi Waller
Zuha Durrani
Sophie Hotchkiss
Asem Bala
Valerie H. Taylor
- Publication date
- 01-12-2025
- Publisher
- Springer US
- Keywords
-
Respiratory Microbiota
Obesity
Obesity - Published in
-
Current Diabetes Reports / Issue 1/2025
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829 - DOI
- https://doi.org/10.1007/s11892-025-01607-0
This content is only visible if you are logged in and have the appropriate permissions.
This content is only visible if you are logged in and have the appropriate permissions.
