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Open Access 01-12-2024 | Respiratory Microbiota | Research

Non-alcoholic fatty liver disease and the gut microbiota in adolescents: is there a relationship?

Authors: Doaa El Amrousy, Heba El Ashry, Sara Maher, Yousef Elsayed, Samir Hasan

Published in: BMC Pediatrics | Issue 1/2024

Abstract

Background

Despite the increasing prevalence of nonalcoholic fatty liver disease (NAFLD), the pathophysiology is still not fully understood. Recent evidence suggests that the gut microbiota may play a role in the pathophysiology of NAFLD and may also offer new therapeutic options.

Methods

This prospective cross-sectional study included 100 consecutive newly diagnosed obese patients (BMI ≥ 95th percentile), aged 14–18 years with NAFLD (confirmed by ultrasound), persistently elevated levels of alanine aminotransferase (ALT) greater than 60 U/L for 1–6 months, and 100 healthy controls. We evaluated changes in the gut microbiota in NAFLD adolescents compared with healthy controls.

Results

According to the multiple logistic regressions, the variables associated with NAFLD were the presence of Clostridium difficile, the presence of Salmonella spp., a greater abundance of Bifidobacterium and Prevotella, and a lower abundance of Lactobacillus.

Conclusion

Changes in the gut microbiota occur in adolescents with NAFLD compared with healthy individuals, which may be useful for identifying youths who are amenable to gut microbiota-based interventions.

Clinical trial number

Not applicable.

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Title: Non-alcoholic fatty liver disease and the gut microbiota in adolescents: is there a relationship?
Authors: Doaa El Amrousy
Heba El Ashry
Sara Maher
Yousef Elsayed
Samir Hasan
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Respiratory Microbiota
Metabolic Dysfunction-Associated Steatotic Liver Disease
Clostridioides Difficile
Published in: BMC Pediatrics / Issue 1/2024
Electronic ISSN: 1471-2431
DOI: https://doi.org/10.1186/s12887-024-05268-y

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Non-alcoholic fatty liver disease and the gut microbiota in adolescents: is there a relationship?

Abstract

Background

Methods

Results

Conclusion

Clinical trial number

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Abstract

Background

Methods

Results

Conclusion

Clinical trial number

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