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Digestive Diseases and Sciences
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28-12-2022 | Respiratory Microbiota | Review

Role of Gut Microbiome in Immune Regulation and Immune Checkpoint Therapy of Colorectal Cancer

Authors: Linsen Shi, Yumei Xu, Min Feng

Published in: Digestive Diseases and Sciences | Issue 2/2023

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Abstract

Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignant tumors worldwide. Immune checkpoint therapies (ICTs) have been proven to be a reliable treatment for some subtypes of CRC. Gut microbiome is closely involved in intestinal carcinogenesis through the regulation of local immune and inflammation of colonic mucosa. Numerous studies have demonstrated that the immunotherapeutic efficacy of CRC and other kinds of cancer is influenced by the immunosuppressive microenvironment constituted by intestinal microbiome and their metabolites. This Review will discuss the recent advances in how gut microbiome can modify the immune microenvironment and its potential role in ICTs of CRC.
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Metadata
Title
Role of Gut Microbiome in Immune Regulation and Immune Checkpoint Therapy of Colorectal Cancer
Authors
Linsen Shi
Yumei Xu
Min Feng
Publication date
28-12-2022
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 2/2023
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-022-07689-0

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