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Reproductive Biology and Endocrinology

Issue 1/2025

Content (96 Articles)

Uterus didelphys: the first case report on molecular profiling of endometrial tissue from both uterine cavities

  • Open Access
  • Research

Alberto Sola-Leyva, Bárbara Romero, Analuce Canha-Gouveia, Inmaculada Pérez-Prieto, Nerea M. Molina, Eva Vargas, Juan Mozas-Moreno, Clara Chamorro, Merli Saare, Andres Salumets, Signe Altmäe

HnRNPM modulates alternative splicing in germ cells by recruiting PTBP1

Peng Lv, Wenchao Xu, Sheng Xin, Yuanxuan Deng, Bin Yang, Dengjianyi Xu, Jian Bai, Deilin Ma, Tao Wang, Jihong Liu, Xiaming Liu

Who freezes her eggs and why? psychological predictors, reasons, and outcomes of social egg freezing

Julia Jeannine Schmid, Seraina Weber, Ulrike Ehlert

Cell-free fat extract improves embryo development and clinical outcomes in older women with previous in-vitro fertilization failure

Xiaowei Zhou, Hanfei Zhu, Jingru Duan, Lan Xia, Shen Zhao, Huihui Xu, Xian Wu, Xiaoling Wang, Bufang Xu, Yi Cao, Aijun Zhang

Looking beyond the ER, PR, and HER2: what’s new in the ARsenal for combating breast cancer?

Tryambak Pratap Srivastava, Ruby Dhar, Subhradip Karmakar

Obesity and recurrent spontaneous abortion: the crucial role of weight management in pregnancy

Rui-Qi Wang, Zhi-Min Deng, Gan-Tao Chen, Fang-Fang Dai, Liang-Bin Xia

Biochanin a modulates steroidogenesis and cellular metabolism in human granulosa cells through TAS2Rs activation: a spotlight on ovarian function

  • Open Access
  • Research

Francesca Paola Luongo, Sofia Passaponti, Alesandro Haxhiu, Irene Ortega Baño, Rosetta Ponchia, Giuseppe Morgante, Paola Piomboni, Alice Luddi

Application of a methodological framework for the development and multicenter validation of reliable artificial intelligence in embryo evaluation

D. Gilboa, Akhil Garg, M. Shapiro, M. Meseguer, Y. Amar, N. Lustgarten, N. Desai, T. Shavit, V. Silva, A. Papatheodorou, A. Chatziparasidou, S. Angras, J. H. Lee, L. Thiel, C. L. Curchoe, Y. Tauber, D. S. Seidman

Association between sleep during pregnancy and birth outcomes: a prospective cohort study

Libing Huang, Huanjun Chen, Fuhui Yao, Zhonghan Sun, Shijiao Yan, Yuwei Lai, Chuanzhu Lv, Xiong-Fei Pan, Rixing Wang, Xingyue Song

Cardiovascular disease risk prediction by Framingham risk score in women with polycystic ovary syndrome

Mina Amiri, Maryam Mousavi, Mahsa Noroozzadeh, Fereidoun Azizi, Fahimeh Ramezani Tehrani

Comparison of vaginal versus intramuscular progesterone in programmed cycles for frozen-thawed blastocyst transfer in patients with endometriosis

Ziqi Jin, Guoxia Yang, Tianrui Wen, Benyu Miao, Chen Wang, Qingyan Zhang, Fang Gu, Yanwen Xu

Enucleated bone marrow-derived mesenchymal stromal cells regulate immune microenvironment and promote testosterone production through efferocytosis

Lu Sun, Jiayu Huang, Xuezi Wang, Peng Huang, Baolin Dong, Zehang Liang, Jiahong Wu, Jiancheng Wang

The role of different LNG-IUS therapies in the management of adenomyosis: a systematic review and meta-analysis

Biyun Zhang, Jinghua Shi, Zhiyue Gu, Yushi Wu, Xiaoyan Li, Chenyu Zhang, Hailan Yan, Qiutong Li, Shiqing Lyu, Yi Dai, Jinhua Leng

Extracellular matrix and pregnancy: functions and opportunities caught in the net

Francesca Rossi, Stefania Luppi, Albina Fejza, Elena Giolo, Giuseppe Ricci, Eva Andreuzzi

Ambient temperature and female infertility prevalence: an ecological study based on the 2019 global burden of disease study

Jiahua Qian, Yuhe Si, Yihao Chen, Yushu Zhu, Jiayu Zhu, Chunbao Mo, Jianxiong Ma

Effects of SARS-CoV-2 infection during IVF treatment on embryo morphokinetics and pregnancy outcomes after fresh transfer: a prospective cohort study

Jialyu Huang, Yuxin Liu, Leizhen Xia, Haisheng Wu, Houyang Chen, Zhihui Huang, Yajie Liao, Xinxia Wan, Hong Chen, Yan Zhao, Frauke von Versen-Höynck, Xingwu Wu

Preimplantation genetic testing for aneuploidy on previously cryopreserved unbiopsied blastocysts: a cohort study in women with IVF pregnancy loss

He Cai, Michal Kirshenbaum, Dian Zhang, Haiyan Bai, Wei Li, Xia Xue, Dongyang Wang, XinXiang Wang, Juanzi Shi

The role of programmed cell death in diabetes mellitus-induced erectile dysfunction: from mechanisms to targeted therapy

Jun Zhang, Sheng Xin, Jiaquan Mao, Xiaming Liu, Tao Wang, Jihong Liu, Xiaodong Song, Wen Song

The proteomic landscape of trophoblasts unravels calcium-dependent syncytialization processes and beta-chorionic gonadotropin (ß-hCG) production

Anna-Lena Gehl, Daniel Klawitter, Ulrich Wissenbach, Marnie Cole, Christine Wesely, Heidi Löhr, Petra Weissgerber, Adela Sota, Markus R. Meyer, Claudia Fecher-Trost

ViLR: a novel virtual long read method for breakpoint identification and direct SNP haplotyping in de novo PGT-SR carriers without a proband

Jiangyang Xue, Min Xie, Jie Cai, Kai Kang, Mengnan Gu, Mai Li, Haiyue Shi, Xin Zhang, Lingyin Kong, Bo Liang, Liming Zhou, Changshui Chen, Haibo Li

Diagnosis and management of infertility in patients with polycystic ovary syndrome (PCOS): guidelines from the Italian Society of Human Reproduction (SIRU) and the Italian Centers for the Study and Conservation of Eggs and Sperm (CECOS Italy)

Stefano Palomba, Giuseppe Seminara, Francesco Tomei, Angelo Marino, Giuseppe Morgante, Domenico Baldini, Enrico Papaleo, Guglielmo Ragusa, Antonio Aversa, Adolfo Allegra, Antonino Guglielmino, Edgardo Somigliana, Tiziana Bartolotti, Domenico Carone, Maria Paola Costantini, Giacomo D’Amico, Annalisa Liprino, Roberto Laganara, Roberto Marci, Mariangela Palmieri, Maria Santo, Laura Sosa Fernandez, Maria Vitale, Aldo Volpes

The diagnostic accuracy of preimplantation genetic testing (PGT) in assessing the genetic status of embryos: a systematic review and meta-analysis

Kexin Chen, Zhixin Hu, Yuxuan Lian, Youzhen Han, Xiaoting Zhou, Yonggang Li, Lifeng Xiang, Weiqun Jiang, Mingying Li, Peng Zeng, Manqin Zhang, Xi Luo, Yongfang Xu, Haishan Zheng, Mei Tian, Mei Wang, Rui Ma, Jichun Yang, Yun Bai, Ruiyu Du, Bo Deng, Ze Wu, Yunxiu Li, Jiacong Yan

Association of LHCGR rs2293275 genotype with ovarian aging in Chinese women: a multicenter population-based study

Wenqing Ma, Shuangmei Ye, Lifeng Tian, Min Liu, Rui Wang, Xuezhou Yang, Man Wang, Fangfang Fu, Wu Ren, Lei Dang, Tian Wang, Wenwen Wang, Shixuan Wang, Yan Sun, Yan Li

Exploring the potential benefits of growth hormone co-treatment on embryo quality in IVF: a randomized controlled open-label trial

Yi Tang, Xiaofeng Li, Change Hu, Ruyi Guan, Zhimin Wang, Shunji Zhang, Guoping Tao, Jingfei Qu, Fei Gong

Retraction Note: Melatonin levels and embryo quality in IVF patients with diminished ovarian reserve: a comparative study

  • Open Access
  • Retraction Note

Yingying Wang, Shangjie Liu, Feifei Gan, Dan Xiong, Xiuming Zhang, Zhou Zheng

FOXL2 drives the differentiation of supporting gonadal cells in early ovarian development

  • Open Access
  • Research

Laura Danti, Karolina Lundin, Petra Nedeczey-Ruzsák, Timo Tuuri, Juha S. Tapanainen

Serum anti-mullerian hormone levels and age among Samoan women

Grace O’Brien, Geralyn Lambert-Messerlian, Nicola L. Hawley, Ulai T. Fidow, Take Naseri, Muagututi‘a Sefuiva Reupena, Erin E. Kershaw, Marinelle B. Azar, Martha M. Pangburn, Stephen T. McGarvey

A novel senotherapeutic strategy with azithromycin for preventing endometriosis progression

Reina Sonehara, Tomoko Nakamura, Takehiko Takeda, Satoshi Kaseki, Tomomi Seki, Hideaki Tanaka, Atsushi Yabuki, Natsuki Miyake, Ayako Muraoka, Satoko Osuka, Akira Iwase, Hiroaki Kajiyama

Broadening the ARMC2 mutational phenotype: linking multiple morphological abnormalities of the Flagella to Pulmonary Manifestations in Primary Ciliary Dyskinesia

Baoyan Wu, Wenhao Zhang, Hui Yu, Lewen Ruan, Kai Wang, Meng Gu, Hao Geng, Jiajun Fang, Chuan Xu, Yuying Sheng, Qing Tan, Qunshan Shen, Zongliu Duan, Huan Wu, Rong Hua, Rui Guo, Zhaolian Wei, Ping Zhou, Yuping Xu, Yunxia Cao, Xiaojin He, Kuokuo Li, Mingrong Lv, Dongdong Tang

Lower pregnancy rate in women with high uterine peristalsis before embryo transfer: a systematic review and meta-analysis

Angela Vidal, Valeria Trejos, Janna Pape, Tanya Karrer, Gürkan Yilmaz, Michael von Wolff

Ovarian tissue cryopreservation for fertility preservation: a two-decade single-center experience with 451 children and adolescents

Norah L. A. Emrich, Rebekka Einenkel, Cara Maria Färber, Andreas Schallmoser, Nicole Sänger

Barriers and enablers to a healthy lifestyle in people with infertility: a qualitative descriptive study

Sophia Torkel, Lisa Moran, Rui Wang, Anthony Villani, Evangeline Mantzioris, Robert J. Norman, Stephanie Cowan

Effect of hysteroscopic septum resection on IVF/ICSI outcomes in women with septate uterus: a propensity-score retrospective matching study

Wei Zhang, Shunzhi He, Xiaoyan Zhang, Zhenteng Liu, Min Chu, Xuemei Liu, Hongchu Bao

Laparoscopically confirmed endometriosis and the risk of incident NAFLD: a prospective cohort study

Hangkai Huang, Zhening Liu, Jiaqi Ruan, Zejun Fang, Chengfu Xu

Predictive potential of combined secretomics and image-based morphometry as a non-invasive method for selecting implanting embryos

  • Open Access
  • Research

Andrea Palomar, Roberto Yagüe-Serrano, Juan Vicente Martínez-Sanchis, Ignacio Iniesta, Alicia Quiñonero, Pedro José Fernández-Colom, Ana Monzó, José María Rubio, Inmaculada Molina, Francisco Domínguez

Equivalent outcomes of human oocytes after vitrification or slow freezing with a modified rehydration protocol

  • Open Access
  • Research

Krzysztof Papis, Karolina Hardej, Ewa Stachowiak, Krystyna Żyżyńska-Galeńska, Piotr Lewandowski, Katarzyna Kozioł

Maternal obesity and the incidence of large-for-gestational-age newborns in isolated hypothyroxinemia pregnancies: a comparative cohort study

Bin Zhang, Sijie Xi, Zhaolong Zhan, Yinglu Zhang, Fengying Lu, Xiaosong Yuan

Comparative analysis of endometrial gland imaging and pinopode detection for assessing endometrial receptivity

Min-bo Zhu, Bei-lei Chen, Meng Cen, Li-ping Chen, Zheng Shi

Progestin-primed ovarian stimulation for oocyte cryopreservation in patients with nonmedical indications: a case–control study

Ophélie Sounigo, Léah Cohen Aloro, Michael Grynberg, Céleste Becquart, Maxence Majer, Vincent Puy, Christophe Sifer, Claire Vinolas, Florence Eustache, Laetita Hesters, Anne Mayeur, Isabelle Cedrin-Durnerin, Charlotte Sonigo, Maeliss Peigné

Psychopharmacological interventions among people who use Assisted Reproductive Technology (ART) — a scoping review

Storman Dawid, Jemioło Paweł, Adamska Dominika, Sawiec Zuzanna

Viral infection and its impact on fertility, medically assisted reproduction and early pregnancy – a narrative review

Laudański Piotr, Zyguła Aleksandra, Czyżyk Adam, Olszak-Wasik Katarzyna, Warzecha Damian, Wojtyła Cezary, Kurzawa Rafał

Phosphate concentrations in follicular fluid during assisted reproductive treatment: relevance for ovarian function and fertility outcomes

Signe Marie Wulff, Mads Joon Jorsal, Ireen Kooij, Hans Krog, Ursula Bentin-Ley, Martin Blomberg Jensen, Sam Kafai Yahyavi

The aryl hydrocarbon receptor: a new frontier in male reproductive system

Ghadeer Bustani, Hasan Alghetaa, Amira Mohammed, Mitzi Nagarkatti, Prakash Nagarkatti

Dissecting the genetic determinants and biological associations between body mass index and female reproductive disorders based on genome-wide association study

Huijing Shao, Chang Xu, Haoran Wang, Nan Lu, Hang Gu, Caihong Zhang, Lirong Li, Qianqian Sun, Rui Guan, Beibei Xuan

Euploidy rate and pregnancy outcomes in preimplantation genetic testing for aneuploidy cycles using progestin-primed ovarian stimulation versus GnRH antagonist protocol

Hu Tan, Li Huang, Wenjuan Liu, Jin Yan, Li Li, Yujiang Wang, Yuqiang Huang, Zonghui Xiao, Fenghua Liu, Xiqian Zhang

Effects of ketogenic diets on polycystic ovary syndrome: a systematic review and meta-analysis

Rossella Cannarella, Michele Rubulotta, Alessia Leonardi, Andrea Crafa, Antonio Calvo, Federica Barbagallo, Sandro La Vignera, Aldo E. Calogero

Engineered extracellular vesicles: a breakthrough approach to overcoming sperm cryopreservation challenges

Abazar Esmaeili, Vahid Esmaeili, Abdolhossein Shahverdi, Mohamadreza Baghaban Eslaminejad

Early menopause in mothers and the risks of pre-diabetes and type 2 diabetes mellitus in female and male offspring: a population-based cohort study

Mahsa Noroozzadeh, Maryam Mousavi, Marzieh Saei Ghare Naz, Maryam Farahmand, Fereidoun Azizi, Fahimeh Ramezani Tehrani

Maternal cafeteria diet adversely affects the reproductive parameters of rat offspring in a sex-specific manner

Emilia Grzęda, Dominika Gutkowska-Kawka, Julia Matuszewska, Ewa Kilańczyk, Monika M. Kaczmarek, Łukasz Dylewski, Joanna H. Sliwowska

Impact of endocrine disrupting chemicals (EDCs) on epigenetic regulation in the uterus: a narrative review

Yinjing Liang, Qinsheng Lu, Miaojuan Chen, Xiaomiao Zhao, Chu Chu, Chaofan Zhang, Jianhuan Yuan, Huimin Liu, Gendie E. Lash

Egg donors’ attitudes toward identifiability, offspring information, and genetic testing

Emilie Lassen, Josephine G. Lemmen, Guido Pennings, Anne-Bine Skytte

Identification and isolation of human testicular peritubular myoid cells and Leydig cells by a combination of ITGA9 and NGFR

Sha Han, Liangyu Zhao, Jiaqiang Luo, Chenkun Shi, Chencheng Yao, Zhiyong Ji, Junwei Xu, Shuai Xu, Ruhui Tian, Erlei Zhi, Yuhua Huang, Xin Liu, Yuchuan Zhou, Zhi Zhou, Zheng Li, Peng Li

The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy

Ramanaiah Mamillapalli, Nimisha Gawde, Madeline Fay, Rula Atwani, Irene Moridi, Hugh S. Taylor

Cumulative live births and predictive factors of emergency oocyte cryopreservation: a retrospective cohort study

Zichuan Han, Tian Tian, Nan Zhang, Jiaxiang Wang, Jia Li, Lixue Chen, Wan Yang, Ping Liu, Rong Li, Jie Qiao, Rui Yang

Fertility and family-building experiences and perspectives of males with cystic fibrosis

Ishaan Jathal, Olivia M. Stransky, Catherine E. Wright, Asher Prangley, Vin Tangpricha, Raksha Jain, Jennifer L. Taylor-Cousar, Kara S. Hughan, Sigrid Ladores-Barrett, Natalie E. West, Gregory S. Sawicki, Traci M. Kazmerski

A prediction model of low birthweight risk in singleton pregnancies reduced from dichorionic twin pregnancies

Minyue Tang, Qingfang Li, Guiquan Wang, Jiayu Xu, Saijun Sun, Yimin Zhu

Association between heavy metal exposure and pregnancy loss: evidence from NHANES 2011–2016

Chiyang Yu, Qingxia You, Xue Bai, Fangxiang Mu

A multidisciplinary approach to weight management and reproductive care: a retrospective cohort study on weight loss through personalized and patient-centered care

Samantha Schon, Jocelyn Spizman, Daria Stelmak, Mark Chames, Stacey Pilarz, Jamila Abdur-Rahman, Charley Jiang, Amal Othman, Marie Menke

Clinical outcome using the Q300™ device in a reproductive laboratory environment: an open-label, non-controlled and non-randomized study

  • Open Access
  • ICSI
  • Research

Yulia Michailov, Eden Amsalem, Natalia Umanski, Valeria Tamadaev, Shevach Friedler, Bozhena Saar-Ryss

BEZ235-Mediated PI3K/mTOR dual inhibition improves ovarian follicle survival in a preclinical model

Jules Bindels, Laëtitia Bernet, Marlyne Squatrito, Michelle Nisolle, Carine Munaut

Short-term impact of tirzepatide on metabolic hypogonadism and body composition in patients with obesity: a controlled pilot study

Sandro La Vignera, Rossella Cannarella, Vincenzo Garofalo, Andrea Crafa, Federica Barbagallo, Rosita A. Condorelli, Aldo E. Calogero

Rapamycin reduces DNA damage of in vitro matured oocytes by promoting Rad51-mediated homologous recombination

  • Open Access
  • ICSI
  • Research

Qiyu Yang, Ying Chen, Jiayu Huang, Junying Tang, Lixia Zhu, Jingyu Li, Chao Tong

The effectiveness of nutritional supplements in improving polycystic ovary syndrome in women: a systematic review and network meta-analysis

Guanhua Zhao, Yuxin Fan, Ruixia Li, Yu Huang, Wenjuan Li, Yanhong Zhao, Mengdi Zhou, Jianchang He

A dual-drug strategy to enhance the function of cryopreserved ovaries by promoting revascularization and inhibiting follicle over-activation

Lingyu Li, Jian Yang, Longzhong Jia, Jing Liang, Kaixin Cheng, Xuebing Yang, Lu Mu, Ge Wang, Kaiying Geng, Qiuxian Hu, Xueqiang Xu, Zhen Li, Guoliang Xia, Ting Guo, Jiawei Zhang, Yan Zhang, Hua Zhang

Energy imbalance in oPOI ovarian granulosa cells is linked to reduced glucose bioavailability and metabolism

Weronika Marynowicz, Paulina Głód, Dawid Maduzia, Justyna Gogola-Mruk, Anna Ptak

Polycystic ovary syndrome and excessive body weight impact independently and synergically on fertility treatment outcomes

Emídio Vale-Fernandes, Mafalda V. Moreira, Raquel L. Bernardino, Daniela Sousa, Raquel Brandão, Carla Leal, Márcia Barreiro, Mariana P. Monteiro

Early androgen activity after birth determines the hypothalamic expression of androgen and estrogen receptors in adulthood in female but not in male rats

Rocío García-Úbeda, Jose Manuel Fernandez-Garcia, Ulises Primo, Daniela Grassi, Antonio Ballesta, Maria Angeles Arevalo, Paloma Collado, Helena Pinos, Beatriz Carrillo

Epigenetic age and fertility timeline: testing an epigenetic clock to forecast in vitro fertilization success rate

Davide Marinello, Marco Reschini, Giorgia Di Stefano, Giorgia Carullo, Maíra Casalechi, Letizia Tarantini, Benedetta Albetti, Valentina Bollati, Paola Viganò, Edgardo Somigliana, Letizia Li Piani

Impact of ejaculation frequency on semen parameters and DNA fragmentation: a cross-sectional study

Qi Xi, Qingkuo Kong, Xin Lv, Rulin Dai, Yang Yu

Letrozole ovulation regimen for frozen-thawed embryo transfer in women with polycystic ovary syndrome: a muti-centre randomised controlled trial

  • Open Access
  • Research

Yanqiu Xie, Ping Li, Guimin Hao, Weifen Deng, Junli Zhao, Shanshan Gao, Bingbing Deng, Yanping Li, Min Deng, Yingying Yuan, Qi Fan, Ningzhen Zhang, Zhiming Zhao, Yuhua Shi

Circadian disruption impairs Leydig cell maturation and reproductive development in male rats

  • Open Access
  • Research

Dijana Z. Travicic, Dejan Miljkovic, Silvana A. Andric, Tatjana S. Kostic

Women’s health knowledge hub

Elevate your patient care with our comprehensive, evidence-based medical education on women's health. Designed to help you provide exceptional care for your female patients at every stage of life, we provide expert insights into topics such as reproductive health, menopause, breast cancer and sex-specific health risks and precision medicine.

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Keynote series | Spotlight on menopause

Menopause can have a significant impact on the body, with effects ranging beyond the endocrine and reproductive systems. Learn about the systemic effects of menopause, so you can help patients in your clinics through the transition.   

Prof. Martha Hickey
Dr. Claudia Barth
Dr. Samar El Khoudary
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