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European Journal of Medical Research
Published in:

Open Access 01-12-2024 | Review

Related factors of bloodstream infections associated with urinary tract infections and pathogenetic characteristics analysis

Authors: Yanxia Shao, Wei Jia, Gang Li

Published in: European Journal of Medical Research | Issue 1/2024

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Abstract

Objectives

To explore correlations between biomarker indices and urosepsis severity, and investigate the prevalence of drug-resistant Escherichia coli in a patient population at the General Hospital of Ningxia Medical University in the Ningxia region of China.

Methods

Patients with urinary tract infection-associated sepsis were categorized into three groups: a septic non-shock group (NSSPU), a septic shock group (USG), and a control group with non-sepsis cases of simple urinary tract infections (CG). The study analyzed various biomarkers, including the percentage of neutrophils (N%), neutrophil-to-lymphocyte ratio (NLR), and lactate (La), to assess their predictive value for urogenital sepsis severity.

Results

The Kruskal–Wallis test showed significant differences in all measured biomarkers between the groups. ROC curve analysis identified N%, NLR, total protein (TP), albumin (ALB), and La as meaningful predictors of urosepsis severity. The combined detection indicators hold greater value in diagnosing uroseptic shock compared to individual test indicators. In addition, the study confirmed the prevalence of drug-resistant E. coli in cases of septic shock.

Conclusion

The combined monitoring of N%, NLR, La, TP, and ALB proves beneficial in the clinical diagnosis of uroseptic shock. This study emphasizes the significance of monitoring Escherichia coli and its resistance patterns to decrease the occurrence of sepsis complications.
Literature
1.
Tan L, Yang C, Yang X, et al. Analysis of the correlative factors of the severity of urogenic sepsis. J South Med Univ. 2019;39(01):93–9 (in Chinese).
2.
3.
Auriti C, Fiscarelli E, Ronchetti MP, et al. Procalcitonin in detecting neonatal nosocomial sepsis. Arch Dis Child Fetal Neonatal Ed. 2012;97(5):F368–70.CrossRefPubMed
4.
Tuzel E, Aktepe OC, Akdogan B. Prospective comparative study of two protocols of antibiotic prophylaxis in percutaneous nephrolithotomy. J Endourol. 2013;27(2):172–6.CrossRefPubMed
5.
Kaukonen KM, Bailey M, Pilcher D, et al. Systemic inflammatory response syndrome criteria and their differential association with mortality. J Crit Care. 2018;46:29–36.CrossRefPubMed
6.
Greene MT, Saint S, Ratz D, et al. Role of transfusions in the development of hospital-acquired urinary tract-related bloodstream infection among United States Veterans. Am J Infect Control. 2019;47(4):381–6.CrossRefPubMed
7.
Saltoglu N, Karali R, Yemisen M, et al. Comparison of community-onset healthcare-associated and hospital-acquired urinary infections caused by extended-spectrum beta-lactamase-producing Escherichia coli and antimicrobial activities. Int J Clin Pract. 2015;69(7):766–70.CrossRefPubMed
8.
Cho YH, Jung SI, Chung HS, et al. Antimicrobial susceptibilities of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in health care-associated urinary tract infection: focus on susceptibility to fosfomycin. Int Urol Nephrol. 2015;47(7):1059–66.CrossRefPubMed
9.
Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315(8):801–10.CrossRefPubMedPubMedCentral
10.
Nagao M. A multicentre analysis of epidemiology of the nosocomial bloodstream infections in Japanese university hospitals. Clin Microbiol Infect. 2013;19(9):852–8.CrossRefPubMed
11.
Saint S, Kaufman SR, Rogers MA, Baker PD, Boyko EJ, Lipsky BA. Risk factors for nosocomial urinary tract-related bacteremia: a case–control study. Am J Infect Control. 2006;34:401–7.CrossRefPubMed
12.
Brolund A, Sundqvist M, Kahlmeter G, Grape M. Molecular characterisation of trimethoprim resistance in Escherichia coli and Klebsiella pneumoniae during a two-year intervention on trimethoprim use. PLoS ONE. 2010;5(2): e9233.CrossRefPubMedPubMedCentral
13.
Bonten M, Johnson JR, van den Biggelaar AHJ, et al. Epidemiology of Escherichia coli bacteremia: a systematic literature review. Clin Infect Dis. 2021;72(7):1211–9.CrossRefPubMed
14.
Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the global burden of disease study. Lancet. 2020;395(10219):200–11.CrossRefPubMedPubMedCentral
15.
Conway LJ, Liu J, Harris AD, Larson EL. Risk factors for bacteremia in patients with urinary catheter-associated bacteriuria. Am J Crit Care. 2016;26:43–52.CrossRefPubMedPubMedCentral
16.
Leibovici L, Greenshtain S, Cohen O, Wysenbeek AJ. Toward improved empiric management of moderate to severe urinary tract infections. Arch Intern Med. 1992;152:2481–6.CrossRefPubMed
17.
18.
Qiu Y, Su Y, Tu GW, et al. Neutrophil-to-lymphocyte ratio predicts mortality in adult renal transplant recipients with severe community-acquired pneumonia. Pathogens. 2020;9(11):913.CrossRefPubMedPubMedCentral
19.
Cataudella E, Giraffa CM, Di Marca S, Pulvirenti A, Alaimo S, Pisano M, Terranova V, Corriere T, Ronsisvalle ML, Di Quattro R, et al. Neutrophil-to-lymphocyte ratio: an emerging marker predicting prognosis in elderly adults with community-acquired pneumonia. J Am Geriatr Soc. 2017;65:1796–801.CrossRefPubMed
20.
De Jager CP, Wever PC, Gemen EF, Kusters R, van Gageldonk-Lafeber AB, van der Poll T, Laheij RJ. The neutrophil–lymphocyte count ratio in patients with community-acquired pneumonia. PLoS ONE. 2012;7: e46561.CrossRefPubMedPubMedCentral
21.
Wu J, Zhang JW, Pang D, et al. Value of neutrophil to lymphocyte ratio in early diagnosis of ureteral calculi complicated by urogenic sepsis. J Modern Urol. 2019;25(10):906–9.
22.
Cui QP, Luo LH, Li TH, et al. Comparison of clinical features between non-shock group and shock group with urinary sepsis. J Modern Urol. 2019;24(1):24–6.
23.
Marik PE, Stephenson E. The ability of procalcitonin, lactate, white blood cell count and neutrophil–lymphocyte count ratio to predict blood stream infection. Analysis of a large database. J Crit Care. 2020;60:135–9.CrossRefPubMed
24.
Zhou JH. Impact of hypoproteinemia on the prognosis of patients with systemic inflammatory response syndrome. Shandong Med. 2008;34:98–9.
25.
Persson MD, Brismar KE, Katzarski KS, et al. Nutritional status using mini nutritional assessment and subjective global assessment predict mortality in geriatric patients. J Am Geriatr Soc. 2002;50(12):1996–2002.CrossRefPubMed
26.
Kiiru S, Maina J, Katana J, et al. Bacterial etiology of urinary tract infections in patients treated at Kenyan health facilities and their resistance towards commonly used antibiotics. PLoS ONE. 2023;18(5): e0277279.CrossRefPubMedPubMedCentral
27.
Rodríguez-Guerrero E, Cabello HR, Expósito-Ruiz M, et al. Antibiotic resistances of Enterobacteriaceae with chromosomal AmpC in urine cultures: review and experience of a Spanish hospital. Antibiotics. 2023;12(4):730.CrossRefPubMedPubMedCentral
28.
29.
Lau SM, Peng MY, Chang FY. Resistance rates to commonly used antimicrobials among pathogens of both bacteremic and non-bacteremic community-acquired urinary tract infection. J Microbiol Immunol Infect. 2004;37(3):185–91.PubMed
30.
Yang Q, Zhang H, Wang Y, et al. Antimicrobial susceptibilities of aerobic and facultative Gram-negative bacilli isolated from Chinese patients with urinary tract infections between 2010 and 2014. BMC Infect Dis. 2017;17(1):192.CrossRefPubMedPubMedCentral
Metadata
Title
Related factors of bloodstream infections associated with urinary tract infections and pathogenetic characteristics analysis
Authors
Yanxia Shao
Wei Jia
Gang Li
Publication date
01-12-2024
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 1/2024
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/s40001-024-02152-4

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