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Pulmonary Hypertension

Sotatercept for advanced PAH lowers the clinical risk

Add-on therapy with sotatercept significantly reduces the risk for death and clinical worsening in patients with advanced pulmonary arterial hypertension at high risk of death.

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Editor's Choice

Magnetic resonance imaging of pediatric pulmonary hypertension

What role can MRI play in diagnosing pulmonary hypertension in children? Learn about the structural, functional, and hemodynamic cardiovascular findings, and how they can be applied to different scenarios.

Global burden of PAH quantified

Findings from the Global Burden of Diseases Injuries and Risk Factors study suggest that the fatal burden of pulmonary arterial hypertension is high but improving over time.

Rodatristat ethyl inappropriate for PAH

Treatment with rodatristat ethyl may worsen pulmonary hemodynamics and cardiac function in adults with pulmonary arterial hypertension.

CPAP treatment for sleep apnea and CV outcomes

CPAP therapy has an important role in the holistic management of obstructive sleep apnea, extending beyond respiratory symptom relief to encompass cardiovascular health benefits. But treatment adherence is crucial.

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Case Studies

HF from a cutaneous hemangioma

Large cutaneous hemangiomas can be hemodynamically significant, resulting in high-output heart failure and pulmonary hypertension. Embolization and resection is effective and well-tolerated.

Unusual cause of respiratory failure

A patient with type II respiratory failure and pulmonary hypertension was diagnosed with RYR1-related myopathy, highlighting the importance of considering congenital myopathies in the differential diagnosis.

Severe pediatric pulmonary hypertension related to scurvy

Pediatric pulmonary hypertension related to vitamin C deficiency can manifest in multiple ways, from mild symptoms to life-threatening episodes characterized by pulmonary hypertensive crises. This educational study looks at two pediatric cases. 

Current Reviews

Prevalence, molecular mechanisms and diagnostic approaches to pulmonary arterial hypertension in connective tissue diseases

Pulmonary arterial hypertension (PAH) is a severe and life-threatening complication in patients with systemic connective tissue diseases (CTD). This review aims to explore the prevalence, clinical implications, diagnostic strategies, and …

Sleep apnea in pulmonary hypertension patients: a systematic review and meta-analysis sleep disorders and pulmonary hypertension

Sleep apnea (SA) is a common and treatable respiratory disorder characterised by hypoventilation, repetitive airflow disruption, and intermittent nocturnal hypoxia, resulting in disrupted sleep duration that may have obstructive or central causes …

Pulmonary Hypertension Associated with Interstitial Lung Disease (PH-ILD): Back to the Future

Pulmonary hypertension (PH) is a progressive syndrome characterized by increased pulmonary artery pressure. PH often complicates chronic lung diseases, thus contributing to a substantial disease burden and poor prognosis. The WHO Group 3 Pulmonary …

Left atrial shunting devices: why, what, how, and… when?

Left atrial (LA) hypertension is central in the pathophysiology of heart failure (HF) in general and of HF with preserved ejection fraction (HFpEF) in particular. Despite approved treatments, a number of HF patients continue experiencing disabling …

Further Reading

Normal ranges of right atrial strain by contemporary echocardiography software: a prospective comparative cohort study

Speckle-tracking echocardiography has evolved into a pivotal component of routine transthoracic echocardiography (TTE) for evaluating chamber function using strain [ 1 ]. Right atrial (RA) strains, including right atrial reservoir (RASr), conduit …

Transformed to myelofibrosis is a risk factor for pulmonary hypertension in Philadelphia chromosome-negative myeloproliferative neoplasms

Philadelphia chromosome-negative myeloproliferative neoplasms (Ph-MPNs) are a group of malignant clonal disorders originating from bone marrow hematopoietic stem cells, and pulmonary hypertension (PH) is a serious progressive disease often …

Lung microvasculopathy in chronic thromboembolic pulmonary hypertension: high-resolution findings with photon-counting detector CT in 29 patients

Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive disease, resulting from the fibrotic transformation of unresolved clots within central and peripheral pulmonary arteries, combined with variable degrees of small-vessel …

A machine learning approach to predict mortality and neonatal persistent pulmonary hypertension in newborns with congenital diaphragmatic hernia. A retrospective observational cohort study

Congenital diaphragmatic hernia (CDH) has high morbidity and mortality rates. This study aimed to develop a machine learning (ML) algorithm to predict outcomes based on prenatal and early postnatal data. This retrospective observational cohort …