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17-06-2024 | Ptosis | Original Articles

Analysis of the Morphology, Rheology, and Clinical Applicability of a Hybrid Injectable with Hyaluronic Acid and Hydroxyapatite

Authors: Pâmela Leticia Santos, Aroldo Geraldo Magdalena, Ana Carolina Ficho, Stephanie da Silveira Pessanha, Jorge Luiz Rosa, Rogério de Lima Romeiro, Thallita Pereira Queiroz

Published in: Aesthetic Plastic Surgery

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Abstract

Background

Treating signs of aging requires skeletal restructuring, facial contour redefinition, and sagging skin treatment. Hence, HarmonyCa® was recently introduced in the market, combining hyaluronic acid and hydroxyapatite. However, there are no studies evaluating the physicochemical properties of this material.

Purpose

To analyze the morphology, rheology, and clinical applicability of HarmonyCa® over a 180-day follow-up.

Methods

A morphological analysis with scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) and rheology measurement with a rheometer. The clinical applicability analysis included a tissue ptosis patient who received the product and was reassessed 30 and 180 days after applying HarmonyCa®.

Results

SEM and EDS analyses showed two distinct morphologies related to hydroxyapatite and hyaluronic acid. The rheological measurements of HarmonyCa® showed G′ and G″ of 51.56 and 44.01 Pa, respectively. The tan δ value was 0.8503, and G* was 108.1 Pa. The clinical outcomes were satisfactory.

Conclusion

HarmonyCa® presents a good synergy between hyaluronic acid and hydroxyapatite. Also, the rheological analysis showed moderate viscosity for the product, with a clinical indication for subcutaneous application.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.​springer.​com/​00266.
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Metadata
Title
Analysis of the Morphology, Rheology, and Clinical Applicability of a Hybrid Injectable with Hyaluronic Acid and Hydroxyapatite
Authors
Pâmela Leticia Santos
Aroldo Geraldo Magdalena
Ana Carolina Ficho
Stephanie da Silveira Pessanha
Jorge Luiz Rosa
Rogério de Lima Romeiro
Thallita Pereira Queiroz
Publication date
17-06-2024
Publisher
Springer US
Published in
Aesthetic Plastic Surgery
Print ISSN: 0364-216X
Electronic ISSN: 1432-5241
DOI
https://doi.org/10.1007/s00266-024-04173-0