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European Journal of Pediatrics

Why think twice before prescribing proton pump inhibitors

Published in:
Authors
An-Sofie Lemmens
Koen Huysentruyt
Yvan Vandenplas
Published in
European Journal of Pediatrics | Issue 3/2025

Abstract

Proton pump inhibitors (PPIs) represent a class of drugs most prominently known for their use in acid-related disorders. Omeprazole, a drug belonging to this class, is among the top 10 most prescribed drugs in the USA. PPIs have a direct effect on the gastric pH and therefore on the gastric mucosa. This review aims to present the most common adverse effects PPIs have on the gastric mucosa in particular.
Conclusion: PPIs affect the composition of gut and gastric microbiota and will eventually modulate the immune response.
What is known:
• Proton-pump inhibitors are amonth the most frequent prescirbed drugs becasue of their well demonstrated efficacy in acid-related disorders.
• Because of their mode of action and their metabolism, a large spectrum of adversee effects have been reported.
What is new:
• Although the well-known success of PPIs in the wide spectrum of all acid-related conditions should not refrain health care professionals to use them when indicated, insufficient attention is given to the multiple adverse effects reported for this class of drugs.
• Well designed prospective trials collecting adverse effects are required, since most studies reporting adverse effects are retrospective, are biassed and have methodological issues.
Title
Why think twice before prescribing proton pump inhibitors
Authors
An-Sofie Lemmens
Koen Huysentruyt
Yvan Vandenplas
Publication date
05-03-2025
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