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Clinical Rheumatology

Open Access 25-09-2024 | ORIGINAL ARTICLE

Protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene polymorphisms (rs2542151, rs7234029) in Egyptian Behçet’s disease patients: a preliminary report

Authors: Doaa H. S. Attia, Marwa Alkaffas, Mervat Eissa, Laila Rashed, Rasha A. M. Khattab, Radwa Elzanaty, Rabab A. Khattab, Lamees A. Samy

Published in: Clinical Rheumatology

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Abstract

Single nucleotide polymorphisms (SNPs) of the protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene have been documented to be linked with several autoimmune disorders including Behçet’s disease (BD). PTPN2 SNPs rs2542151 and rs7234029 have been assessed using real-time PCR in 96 BD patients and 50 controls matched by age and gender. Patients were categorized into groups according to the disease phenotypes and severity. A total of 94.8% of patients were males. The patients’ mean age at onset was 26.1 ± 8 years. The median (IQR) disease duration was 8.5(4–13) years. No difference was observed between the patients and controls concerning the frequency of the two SNPs’ different genotypes, models, and alleles. Moreover, neither disease phenotypes nor severity were associated with rs2542151 or rs7234029 SNPs. PTPN2 rs2542151 and rs7234029 SNPs do not seem to have associations with BD occurrence, phenotypes, or severity in the Egyptian patients.
Key Points
• PTPN2 rs2542151 and rs7234029 SNPs do not seem to have associations with BD occurrence, phenotypes, or severity in the Egyptian patients.
• Further studies involving a larger sample size with variable clinical diversity are recommended to verify the results.
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Metadata
Title
Protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene polymorphisms (rs2542151, rs7234029) in Egyptian Behçet’s disease patients: a preliminary report
Authors
Doaa H. S. Attia
Marwa Alkaffas
Mervat Eissa
Laila Rashed
Rasha A. M. Khattab
Radwa Elzanaty
Rabab A. Khattab
Lamees A. Samy
Publication date
25-09-2024
Publisher
Springer International Publishing
Published in
Clinical Rheumatology
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-024-07128-7

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