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26-07-2023 | Prostatectomy | Original Article

The Changes in Gleason Score Between the Diagnostic Biopsy and Radical Prostatectomy Pathology

Authors: Jieping Hu, Yanyan Hong, Mengzhen Wang, Jin Zeng, Weipeng Liu

Published in: Indian Journal of Surgery | Issue 2/2024

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Abstract

A total of 100 patients diagnosed with prostate cancer via transrectal ultrasound biopsies and who underwent radical prostatectomy were identified; patients were divided into three groups: downgrade, consistent, and upgrade. Forty-four (44%) patients had a Gleason score downgrade, twenty (20%) patients had a Gleason score upgrade, and thirty-six (36%) had a consistent Gleason score. The changes range from − 6 to 2, forty-seven (47%) patients had one grade jump between biopsy and radical surgery specimen, and seventeen (17%) had more than one grade jump. Gleason scores of 6 and 7 were the risk factor of upgrade (odds ratio = 27.844, 95% confidence interval, CI = 2.427–319.379, p = 0.008; and odds ratio = 14.391, 95% CI = 1.331–155.626, p = 0.028; respectively), and subgroup analysis indicated secondary Gleason grade = 3 was the risk factor of upgrade (odds ratio = 6.732, 95% CI = 1.059–42.804, p = 0.043); primary Gleason grade, age, prostate volume, and positive biopsy cores were not associated with Gleason score changes. Most prostate cancer biopsy patients had changes in their Gleason scores and histopathologic scores. For patients with risk factors for score changes, it was necessary to carefully evaluate and formulate optimal treatment methods, including surgical methods.
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Metadata
Title
The Changes in Gleason Score Between the Diagnostic Biopsy and Radical Prostatectomy Pathology
Authors
Jieping Hu
Yanyan Hong
Mengzhen Wang
Jin Zeng
Weipeng Liu
Publication date
26-07-2023
Publisher
Springer India
Published in
Indian Journal of Surgery / Issue 2/2024
Print ISSN: 0972-2068
Electronic ISSN: 0973-9793
DOI
https://doi.org/10.1007/s12262-023-03882-1

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