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Open Access 26-07-2023 | Prostate Cancer | Special Section: PET/MR

PSMA PET imaging in the diagnosis and management of prostate cancer

Authors: Sina Houshmand, Courtney Lawhn-Heath, Spencer Behr

Published in: Abdominal Radiology | Issue 12/2023

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Abstract

Prostate cancer is the second leading cause of cancer-related deaths in men in the United States. Imaging techniques such as CT, MRI, and bone scans have traditionally been used for diagnosis and staging. Molecular imaging modalities targeting the prostate-specific membrane antigen (PSMA) have recently gained attention due to their high affinity and accuracy. PSMA PET has been combined with other modalities such as multiparametric MRI for better diagnostic and prognostic performance. PSMA imaging has been studied at different clinical settings with a wide range of disease aggressiveness. In this review we will explore the role of PSMA PET in high-risk prostate cancer staging, biochemical recurrence, and castration-resistant prostate cancer. The primary focus of this review article is to examine the latest developments in the use of PSMA imaging and emphasize the clinical situations where its effectiveness has been demonstrated to significantly impact the treatment of prostate cancer. In addition, we will touch upon the potential future advancements of PSMA PET imaging and its evolving significance in the management of prostate cancer.

Graphical abstract

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Metadata
Title
PSMA PET imaging in the diagnosis and management of prostate cancer
Authors
Sina Houshmand
Courtney Lawhn-Heath
Spencer Behr
Publication date
26-07-2023
Publisher
Springer US
Published in
Abdominal Radiology / Issue 12/2023
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-023-04002-z

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