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Journal of Endocrinological Investigation

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01-04-2023 | Prostate Cancer | Short Review

Endocrine-disrupting chemicals (EDCs) and cancer: new perspectives on an old relationship

Authors: R. Modica, E. Benevento, A. Colao

Published in: Journal of Endocrinological Investigation | Issue 4/2023

Abstract

Purpose

Environmental endocrine-disrupting chemicals (EDCs) are a mixture of chemical compounds capable to interfere with endocrine axis at different levels and to which population is daily exposed. This paper aims to review the relationship between EDCs and breast, prostate, testicle, ovary, and thyroid cancer, discussing carcinogenic activity of known EDCs, while evaluating the impact on public health.

Methods

A literature review regarding EDCs and cancer was carried out with particular interest on meta-analysis and human studies.

Results

The definition of EDCs has been changed through years, and currently there are no common criteria to test new chemicals to clarify their possible carcinogenic activity. Moreover, it is difficult to assess the full impact of human exposure to EDCs because adverse effects develop latently and manifest at different ages, even if preclinical and clinical evidence suggest that developing fetus and neonates are most vulnerable to endocrine disruption.

Conclusion

EDCs represent a major environmental and health issue that has a role in cancer development. There are currently some EDCs that can be considered as carcinogenic, like dioxin and cadmium for breast and thyroid cancer; arsenic, asbestos, and dioxin for prostate cancer; and organochlorines/organohalogens for testicular cancer. New evidence supports the role of other EDCs as possible carcinogenic and pregnant women should avoid risk area and exposure. The relationship between EDCs and cancer supports the need for effective prevention policies increasing public awareness.

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Title: Endocrine-disrupting chemicals (EDCs) and cancer: new perspectives on an old relationship
Authors: R. Modica
E. Benevento
A. Colao
Publication date: 01-04-2023
Publisher: Springer International Publishing
Keywords: Prostate Cancer
Prostate Cancer
Thyroid Cancer
Thyroid Cancer
Thyroid Cancer
Breast Cancer
Breast Cancer
Published in: Journal of Endocrinological Investigation / Issue 4/2023
Electronic ISSN: 1720-8386
DOI: https://doi.org/10.1007/s40618-022-01983-4

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A quick guide to ECGs

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ERS Congress 2024

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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