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16-01-2024 | Propofol | Original Paper

Propofol Reversibly Attenuates Short-Range Microstate Ordering and 20 Hz Microstate Oscillations

Authors: Gesine Hermann, Inken Tödt, Enzo Tagliazucchi, Inga Karin Todtenhaupt, Helmut Laufs, Frederic von Wegner

Published in: Brain Topography | Issue 2/2024

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Abstract

Microstate sequences summarize the changing voltage patterns measured by electroencephalography, using a clustering approach to reduce the high dimensionality of the underlying data. A common approach is to restrict the pattern matching step to local maxima of the global field power (GFP) and to interpolate the microstate fit in between. In this study, we investigate how the anesthetic propofol affects microstate sequence periodicity and predictability, and how these metrics are changed by interpolation. We performed two frequency analyses on microstate sequences, one based on time-lagged mutual information, the other based on Fourier transform methodology, and quantified the effects of interpolation. Resting-state microstate sequences had a 20 Hz frequency peak related to dominant 10 Hz (alpha) rhythms, and the Fourier approach demonstrated that all five microstate classes followed this frequency. The 20 Hz periodicity was reversibly attenuated under moderate propofol sedation, as shown by mutual information and Fourier analysis. Characteristic microstate frequencies could only be observed in non-interpolated microstate sequences and were masked by smoothing effects of interpolation. Information-theoretic analysis revealed faster microstate dynamics and larger entropy rates under propofol, whereas Shannon entropy did not change significantly. In moderate sedation, active information storage decreased for non-interpolated sequences. Signatures of non-equilibrium dynamics were observed in non-interpolated sequences, but no changes were observed between sedation levels. All changes occurred while subjects were able to perform an auditory perception task. In summary, we show that low dose propofol reversibly increases the randomness of microstate sequences and attenuates microstate oscillations without correlation to cognitive task performance. Microstate dynamics between GFP peaks reflect physiological processes that are not accessible in interpolated sequences.
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Literature
go back to reference Akeju O, Pavone KJ, Westover MB, Vazquez R, Prerau MJ, Harrell PG, Hartnack KE, Rhee J, Sampson AL, Habeeb K, Gao L, Pierce ET, Walsh JL, Brown EN, Purdon PL (2014) A comparison of Propofol- and dexmedetomidine-induced Electroencephalogram Dynamics Using Spectral and coherence analysis. Anesthesiology 121(5):978–989. https://doi.org/10.1097/ALN.0000000000000419CrossRefPubMed Akeju O, Pavone KJ, Westover MB, Vazquez R, Prerau MJ, Harrell PG, Hartnack KE, Rhee J, Sampson AL, Habeeb K, Gao L, Pierce ET, Walsh JL, Brown EN, Purdon PL (2014) A comparison of Propofol- and dexmedetomidine-induced Electroencephalogram Dynamics Using Spectral and coherence analysis. Anesthesiology 121(5):978–989. https://​doi.​org/​10.​1097/​ALN.​0000000000000419​CrossRefPubMed
go back to reference Iber C, Ancoli-Israel S, Chesson A, Quan SF (2007) The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications, 1st edn. American Academy of Sleep Medicine, Darien Iber C, Ancoli-Israel S, Chesson A, Quan SF (2007) The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications, 1st edn. American Academy of Sleep Medicine, Darien
go back to reference Kales A, Rechtschaffen A (1968). A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects, vol 204. Government Printing Office, Washington DC Kales A, Rechtschaffen A (1968). A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects, vol 204. Government Printing Office, Washington DC
go back to reference Seabold S, Perktold J (2010) statsmodels: econometric and statistical modeling with python. In 9th python in science conference Seabold S, Perktold J (2010) statsmodels: econometric and statistical modeling with python. In 9th python in science conference
go back to reference Strik WK, Chiaramonti R, Muscas GC, Paganini M, Mueller TJ, Fallgatter AJ, Versari A, Zappoli R (1997) Decreased EEG microstate duration and anteriorisation of the brain electrical fields in mild and moderate Dementia of the Alzheimer type. Psychiatry Res: Neuroimaging 75(3):183–191. https://doi.org/10.1016/S0925-4927(97)00054-1CrossRef Strik WK, Chiaramonti R, Muscas GC, Paganini M, Mueller TJ, Fallgatter AJ, Versari A, Zappoli R (1997) Decreased EEG microstate duration and anteriorisation of the brain electrical fields in mild and moderate Dementia of the Alzheimer type. Psychiatry Res: Neuroimaging 75(3):183–191. https://​doi.​org/​10.​1016/​S0925-4927(97)00054-1CrossRef
go back to reference Van Rossum G, Drake FL (2009) Python 3 reference manual. CreateSpace 121:242 Van Rossum G, Drake FL (2009) Python 3 reference manual. CreateSpace 121:242
go back to reference Virtanen P, Gommers R, Oliphant TE, Haberland M, Reddy T, Cournapeau D, Burovski E, Peterson P, Weckesser W, Bright J, van der Walt SJ, Brett M, Wilson J, Millman KJ, Mayorov N, Nelson ARJ, Jones E, Kern R, Larson E, …, Vázquez-Baeza Y (2020) SciPy 1.0: fundamental algorithms for scientific computing in Python. Nat Methods 17(3):261–272. https://doi.org/10.1038/s41592-019-0686-2CrossRefPubMedPubMedCentral Virtanen P, Gommers R, Oliphant TE, Haberland M, Reddy T, Cournapeau D, Burovski E, Peterson P, Weckesser W, Bright J, van der Walt SJ, Brett M, Wilson J, Millman KJ, Mayorov N, Nelson ARJ, Jones E, Kern R, Larson E, …, Vázquez-Baeza Y (2020) SciPy 1.0: fundamental algorithms for scientific computing in Python. Nat Methods 17(3):261–272. https://​doi.​org/​10.​1038/​s41592-019-0686-2CrossRefPubMedPubMedCentral
Metadata
Title
Propofol Reversibly Attenuates Short-Range Microstate Ordering and 20 Hz Microstate Oscillations
Authors
Gesine Hermann
Inken Tödt
Enzo Tagliazucchi
Inga Karin Todtenhaupt
Helmut Laufs
Frederic von Wegner
Publication date
16-01-2024
Publisher
Springer US
Keyword
Propofol
Published in
Brain Topography / Issue 2/2024
Print ISSN: 0896-0267
Electronic ISSN: 1573-6792
DOI
https://doi.org/10.1007/s10548-023-01023-1

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