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Archives of Gynecology and Obstetrics

The influence of antenatal betamethasone timing on neonatal outcome in late preterm infants: a single-center cohort study

Published in:
Authors
Thomas Brückner
Anke Redlich
Published in
Archives of Gynecology and Obstetrics | Issue 4/2025

Abstract

Purpose

Many pregnancies continue after antenatal corticosteroid exposure. Since long-term effects on late preterm neonatal outcome remain controversial, it remains unknown whether pregnant women who are at risk for preterm birth during the late preterm period and had prior antenatal corticosteroid exposure would benefit from an additional course of antenatal corticosteroids. We evaluated the need for future trials on this topic by comparing short term effects from antenatal betamethasone to long-term effects. We also examined the value of a risk-adapted approach.

Methods

We observed neonatal outcomes in late preterm infants (34/0–36/0 weeks of gestation) who were exposed to antenatal betamethasone either up to 10 days prior birth (n = 8) or earlier in pregnancy (n = 89). We examined a real world population from the University Hospital Magdeburg (Germany) between 01 January 2012 and 31 December 2018, and a simulated high-risk population that was derived from the original data.

Results

The indicators for relevant adverse outcomes did not differ in the unselected population. In the simulated high-risk population, recent antenatal corticosteroid administration significantly reduced the incidence of relevant cardiorespiratory morbidities (OR = 0.00, p = 0.008), and reduced the number needed to treat from 3.7 to 1.5.

Conclusion

The superiority of recent antenatal corticosteroid administration in the late preterm period over earlier exposure strongly depended on the prevalence of respiratory disease. Before considering clinical trials on additional antenatal corticosteroid courses in the late preterm period, antenatal assessment tools to predict respiratory morbidity need to be developed.
Title
The influence of antenatal betamethasone timing on neonatal outcome in late preterm infants: a single-center cohort study
Authors
Thomas Brückner
Anke Redlich
Publication date
09-09-2024
Publisher
Springer Berlin Heidelberg
Keyword
Premature Birth
Published in
Archives of Gynecology and Obstetrics / Issue 4/2025
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-024-07714-9
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