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Open Access 01-12-2022 | Pre-Eclampsia | Research

Dietary carotenoid intake and risk of developing preeclampsia: a hospital-based case–control study

Authors: Ting Kang, Yanhua Liu, Xi Chen, Xuemin Huang, Yuan Cao, Weifeng Dou, Dandan Duan, Yacong Bo, Stanislav Seydou Traore, Xianlan Zhao, Wenjun Fu, Fangfang Zeng, Jun Liu, Quanjun Lyu

Published in: BMC Pregnancy and Childbirth | Issue 1/2022

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Abstract

Background

The effect of carotenoids on the risk of preeclampsia (PE) is uncertain. We aimed to examine the associations between the intake of dietary carotenoids and related compounds by pregnant women in China, and the risk of their developing PE.

Methods

Four hundred and forty PE cases and 440 age- (± 3 years), gestational age- (± 1 weeks) and gestational diabetes mellitus status- (yes/no) matched healthy controls were recruited from March 2016 to June 2019. Dietary intake of carotenoids was assessed using a 79-item validated food-frequency questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression.

Results

After adjusting for potential confounders, we found that the intake of total carotenoids, β-carotene, β-cryptoxanthin, lycopene, and lutein and zeaxanthin (lut-zea) were negatively associated with the odds of developing PE. Compared with the lowest quartile intake, the multivariate-adjusted OR (95% CI) of the highest quartile intake was 0.29 (0.16–0.54, Ptrend <  0.001) for total carotenoids, 0.31 (0.16–0.58, Ptrend <  0.001) for β-carotene, 0.50 (0.27–0.90, Ptrend = 0.007) for β-cryptoxanthin, 0.55 (0.30–0.99, Ptrend = 0.04) for lycopene and 0.32 (0.17–0.61, Ptrend = 0.001) for lut-zea. However, no significant associations were observed between the risk of developing PE and α-carotene intake (OR = 0.75, 95% CI: 0.41–1.36, Ptrend = 0.28). Moreover, similar negative associations were found for every one-standard-deviation increase in the intake of total carotenoids, β-carotene, β-cryptoxanthin, lycopene and lut-zea.

Conclusion

These results indicate that a high intake of total carotenoids, β-carotene, β-cryptoxanthin, lycopene and lut-zea may be associated with a low risk of developing PE.
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Metadata
Title
Dietary carotenoid intake and risk of developing preeclampsia: a hospital-based case–control study
Authors
Ting Kang
Yanhua Liu
Xi Chen
Xuemin Huang
Yuan Cao
Weifeng Dou
Dandan Duan
Yacong Bo
Stanislav Seydou Traore
Xianlan Zhao
Wenjun Fu
Fangfang Zeng
Jun Liu
Quanjun Lyu
Publication date
01-12-2022
Publisher
BioMed Central
Keyword
Pre-Eclampsia
Published in
BMC Pregnancy and Childbirth / Issue 1/2022
Electronic ISSN: 1471-2393
DOI
https://doi.org/10.1186/s12884-022-04737-5

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