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Journal of Neural Transmission
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21-01-2023 | Positron Emission Tomography | Psychiatry and Preclinical Psychiatric Studies - Original Article

Is abnormal metabolism in the olfactory bulb and amygdala associated with bipolar disorder?

Authors: Muhammet Sancaktar, Şengül Kocamer Şahin, Bahadır Demir, Umut Elboğa, Gülçin Elboğa, Abdurrahman Altındağ

Published in: Journal of Neural Transmission | Issue 2/2023

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Abstract

Accumulated evidence has demonstrated abnormal amygdala activation in bipolar disorder (BD). The olfactory bulb (OB) has vigorous connections with the amygdala. Although odor-related functions of the OB decreased during the evolutionary process, we hypothesized that an evolved OB with increased activation in emotion regulation may be one of the main factors affecting amygdala functions in BD. Our aim was to investigate metabolism in the OB and amygdala in patients with BD. Twenty-six patients diagnosed with BD according to DSM-5 diagnostic criteria were included in this cross-sectional study. Metabolism in the OB and amygdala was assessed using fluorodeoxyglucose positron emission tomography/CT in patients with BD. The OB and amygdala metabolism was compared with the patients’ Z scores. Both OB and amygdala metabolic activities were significantly higher than in the controls. A positive correlation was detected between right/left amygdala metabolism and right OB metabolism (p < 0.05, r:467 and r:662, respectively). This study increased our understanding of the etiopathogenesis of BD. In BD, the main cause of hypermetabolism in the amygdala may be increased metabolism in the OB. During evolution, the OB may have assumed a dominant role in emotional processing rather than olfactory functions.
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Metadata
Title
Is abnormal metabolism in the olfactory bulb and amygdala associated with bipolar disorder?
Authors
Muhammet Sancaktar
Şengül Kocamer Şahin
Bahadır Demir
Umut Elboğa
Gülçin Elboğa
Abdurrahman Altındağ
Publication date
21-01-2023
Publisher
Springer Vienna
Published in
Journal of Neural Transmission / Issue 2/2023
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-023-02587-9

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