Skip to main content
Key Specialties
Anesthesiology Cardiology Dermatology Diabetology Endocrinology Gastroenterology General Medicine Geriatrics Hematology Infectious Diseases Internal Medicine Nephrology Neurology Obstetrics and Gynecology Oncology Pediatrics Psychiatry Radiology Respiratory Medicine Rheumatology Surgery Urology
Congress Coverage
ASH 2024 Annual Meeting 2024 ESMO Congress 2024 ERS Congress 2024 EASD Congress 2024 ESC Congress 2024 EAN Congress 2024 ASCO Annual Meeting 2024 ACC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote series | Spotlight on menopause

Menopause can have a significant impact on the body, with effects ranging beyond the endocrine and reproductive systems. Learn about the systemic effects of menopause, so you can help patients in your clinics through the transition.

Published: Thursday 12th December 2024
ADVANCED SEARCH
Log in
Top
Diagnostic Pathology
Published in:

Open Access 01-12-2024 | Positron Emission Tomography | Case Report

Hyalinizing clear cell carcinoma of the lung: a case report and literature review

Authors: Yu-Ju Su, Yun-Shao Wu, Cheng-Hung How, Min-Shu Hsieh

Published in: Diagnostic Pathology | Issue 1/2024

Login to get access

Abstract

Background

Primary pulmonary hyalinizing clear cell carcinoma (HCCC) is an exceedingly rare tumor with unique clinicopathological features, posing major diagnostic challenges.

Case presentation

We present a case of a 74-year-old woman with a lung nodule incidentally detected in the right middle lobe (RML) through 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) imaging. Through comprehensive evaluations by thoracic surgeons, she underwent video-assisted thoracic surgery of RML lobectomy to excise the lung nodule. Subsequent histopathological and immunohistochemical analyses confirmed the nodule as HCCC. She was discharged without any postoperative complications. No recurrence has been observed after two years of follow-up. This case underscored the importance of comprehensive imaging modalities and pathological analysis in the management of primary pulmonary HCCC.

Conclusions

This report highlights the critical role of imaging techniques and pathological analysis in diagnosing primary pulmonary HCCC, with this case demonstrating the essential value of 18F-FDG PET/CT integration.
Literature
1.
Wu YL, Wu F, Cao MF, Lan Y, Du MS, Yu ST, et al. Primary pulmonary hyalinizing clear cell carcinoma with fusions of both EWSR1::CREM and IRF2::NTRK3: report of a case with an aggressive behavior. Front Oncol. 2023;13:1175279.CrossRefPubMedPubMedCentral
2.
Solar AA, Schmidt BL, Jordan RC. Hyalinizing clear cell carcinoma: case series and comprehensive review of the literature. Cancer. 2009;115(1):75–83.CrossRefPubMed
3.
Chen L, Zhou N, Hu S, Wang F, Xu T, Li T, et al. Hyalinising clear cell carcinoma of the lung: a case report and review of literature. Med (Baltim). 2023;102(25):e34101.CrossRef
4.
5.
Bisschop C, de Heer EC, Brouwers AH, Hospers GAP, Jalving M. Rational use of 18F-FDG PET/CT in patients with advanced cutaneous melanoma: a systematic review. Crit Rev Oncol/Hematol. 2020;153:103044.CrossRefPubMed
6.
Milchgrub S, Gnepp DR, Vuitch F, Delgado R, Albores-Saavedra J. Hyalinizing clear cell carcinoma of salivary gland. Am J Surg Pathol. 1994;18(1):74–82.CrossRefPubMed
7.
García JJ, Jin L, Jackson SB, Larsen BT, Lewis JE, Sukov WR, et al. Primary pulmonary hyalinizing clear cell carcinoma of bronchial submucosal gland origin. Hum Pathol. 2015;46(3):471–5.CrossRefPubMed
8.
Tsao MS, Nicholson AG, Maleszewski JJ, Marx A, Travis WD. Introduction to 2021 WHO classification of thoracic tumors. J Thorac Oncol. 2022;17(1):e1–4.CrossRefPubMed
9.
10.
Wang H, Li WY, Kuo YJ, Yeh YC, Hsieh MS. Primary pulmonary hyalinising clear cell carcinoma with mucin production and delayed metastases after 16 years. Pathology. 2016;48(5):518–21.CrossRefPubMed
11.
12.
Seifert G. Classification and differential diagnosis of clear and basal cell tumors of the salivary glands. Semin Diagn Pathol. 1996;13:95e103. PMID: 8734415.
13.
Chapman E, Skalova A, Ptakova N, Martinek P, Goytain A, Tucker T, et al. Molecular profiling of Hyalinizing Clear Cell Carcinomas revealed a subset of tumors harboring a Novel EWSR1-CREM Fusion: report of 3 cases. Am J Surg Pathol. 2018;42(9):1182–9.CrossRefPubMed
14.
Agaram NP, Chen HW, Zhang L, Sung YS, Panicek D, Healey JH, et al. EWSR1-PBX3: a novel gene fusion in myoepithelial tumors. Genes Chromosomes Cancer. 2015;54(2):63–71.CrossRefPubMed
15.
Roden AC, García JJ, Wehrs RN, Colby TV, Khoor A, Leslie KO, et al. Histopathologic, immunophenotypic and cytogenetic features of pulmonary mucoepidermoid carcinoma. Mod Pathol. 2014;27(11):1479–88.CrossRefPubMed
16.
17.
18.
19.
20.
Gubbiotti MA, Montone K, Zhang P, Livolsi V, Baloch Z. A contemporary update on hyalinizing clear cell carcinoma: compilation of all in-house cases at our institution and a literature review spanning 2015–2020. Hum Pathol. 2021;111:45–51.CrossRefPubMed
Metadata
Title
Hyalinizing clear cell carcinoma of the lung: a case report and literature review
Authors
Yu-Ju Su
Yun-Shao Wu
Cheng-Hung How
Min-Shu Hsieh
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2024
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/s13000-024-01579-x

Other articles of this Issue 1/2024

Correlation analysis of risk factors for cervical lymphatic metastasis in papillary thyroid carcinoma

Difficulty in diagnosing intracranial infection caused by Mycobacterium avium in an AIDS patient: case report and review of the literature

High incidence of HPV infection in minors with oral squamous cell carcinoma

Spindle epithelial tumor with thymus-like elements (SETTLE): a diagnostic challenge with distinct therapeutic implication; case report

CIC::NUTM1 sarcomas occurred in soft tissues of upper limbs : a rare case report and literature review

Prognostic and immune infiltration implications of SIGLEC9 in SKCM