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25-09-2024 | Polycystic Ovary Syndrome | REVIEW

Effects of Intermittent Fasting on Female Reproductive Function: A Review of Animal and Human Studies

Authors: Lei Mao, Aixia Liu, Xiaohui Zhang

Abstract

Purpose of Review

Intermittent fasting has gained significant attention, yet a comprehensive understanding of its impact on female reproductive health is lacking. This review aims to fill this gap by examining various intermittent fasting regimens and their effects on female reproductive function, along with potential mechanisms.

Recent Findings

In healthy non-overweight/obese or pregnant animal models, alternate-day fasting (ADF) and an 8-h time-restricted feeding (TRF) window may have adverse effects on reproductive function. However, these regimens show potential to mitigate negative consequences induced by a high-fat diet (HFD) or environmental exposure. A 10-h TRF demonstrates benefits in improving fertility in both normal-weight and HFD-fed animal models. In women with overweight/obesity or polycystic ovary syndrome (PCOS), the 5:2 diet and TRF significantly reduce the free androgen index while elevating sex hormone binding globulin, promising improvements in menstrual regulation. For pregnant Muslim women, available data do not strongly indicate adverse effects of Ramadan fasting on preterm delivery, but potential downsides to maternal weight gain, neonatal birthweight, and long-term offspring health need consideration. Factors linking intermittent fasting to female reproductive health include the circadian clock, gut microbiota, metabolic regulators, and modifiable lifestyles.

Summary

Drawing definitive conclusions remains challenging in this evolving area. Nonetheless, our findings underscore the potential utility of intermittent fasting regimens as a therapeutic approach for addressing menstruation irregularities and infertility in women with obesity and PCOS. On the other hand, pregnant women should remain cognizant of potential risks associated with intermittent fasting practices.

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Title: Effects of Intermittent Fasting on Female Reproductive Function: A Review of Animal and Human Studies
Authors: Lei Mao
Aixia Liu
Xiaohui Zhang
Publication date: 25-09-2024
Publisher: Springer US
Keywords: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome
Fertility
Testosterone
Published in: Current Nutrition Reports
Electronic ISSN: 2161-3311
DOI: https://doi.org/10.1007/s13668-024-00569-1

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Effects of Intermittent Fasting on Female Reproductive Function: A Review of Animal and Human Studies

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Abstract

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Summary

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