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General Thoracic and Cardiovascular Surgery

Open Access 06-09-2024 | Pneumonia | Original Article

Post-lung transplant outcomes of connective tissue disease-related interstitial lung diseases compared with idiopathic interstitial pneumonia: a single-center experience in Japan

Authors: Miho Yamaguchi, Takafumi Yamaya, Mitsuaki Kawashima, Chihiro Konoeda, Hidenori Kage, Masaaki Sato

Published in: General Thoracic and Cardiovascular Surgery

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Abstract

Objectives

The aim of this study was to investigate the outcomes of lung transplantation for connective tissue disease-related interstitial lung disease (CTD-ILD) conducted at our institution, compared with those for idiopathic interstitial pneumonias (IIPs).

Methods

We retrospectively reviewed patients with CTD-ILD and IIPs who underwent lung transplantation at our hospital from July 2015 to October 2023. We compared patients’ backgrounds, early complications within 28 days post-transplant (CTCAE grade 3 or higher), postoperative courses, and prognoses between the two groups.

Results

The CTD-ILD group (n = 19) and the IIPs group (n = 56) were compared. The CTD-ILD group had significantly higher preoperative use of corticosteroids and antifibrotic agents, mean pulmonary arterial pressure, anti-human leukocyte antigen antibody positivity, and donor age (p < 0.05). In addition, the CTD-ILD group had significantly longer operation times (579.0 vs 442.5 min), longer stays in the intensive care unit (17.0 vs 9.0 days) and hospital (58.0 vs 44.0 days); required more tracheostomies (57.9 vs 25.0%); and experienced more respiratory (52.6 vs 25.0%) and gastrointestinal (42.1 vs 8.9%) complications (p < 0.05). However, there were no significant differences in overall survival, nor chronic lung allograft dysfunction (CLAD)-free survival between the two groups.

Conclusion

Perioperative complications, notably respiratory and gastrointestinal complications, were prevalent after lung transplantation among CTD-ILD patients. Despite this, long-term survival rates were comparable to those observed in IIP cases.
Literature
1.
Chambers DC, Perch M, Zuckermann A, Cherikh WS, Harhay MO, Hayes DJ, et al. The international thoracic organ transplant registry of the international society for heart and lung transplantation: thirty-eighth adult lung transplantation report - 2021; focus on recipient characteristics. J Heart Lung Transplant. 2021;40:1060–72.CrossRefPubMedPubMedCentral
2.
3.
Nagata S, Ohsumi A, Handa T, Yamada Y, Tanaka S, Yutaka Y, et al. Assessment of listing criteria for lung transplant candidates with interstitial lung disease. Gen Thorac Cardiovasc Surg. 2023;71:20–6.CrossRefPubMed
4.
Tangaroonsanti A, Lee AS, Crowell MD, Vela MF, Jones DR, Erasmus D, et al. Impaired esophageal motility and clearance post-lung transplant: risk for chronic allograft failure. Clin Transl Gastroenterol. 2017;8: e102.CrossRefPubMedPubMedCentral
5.
Sottile PD, Iturbe D, Katsumoto TR, Connolly MK, Collard HR, Leard LA, et al. Outcomes in systemic sclerosis-related lung disease after lung transplantation. Transplantation. 2013;95:975–80.CrossRefPubMedPubMedCentral
6.
Miele CH, Schwab K, Saggar R, Duffy E, Elashoff D, Tseng C-H, et al. Lung transplant outcomes in systemic sclerosis with significant esophageal dysfunction. A comprehensive single-center experience. Ann Am Thorac Soc. 2016;13:793–802.CrossRefPubMedPubMedCentral
7.
Crespo MM, Bermudez CA, Dew MA, Johnson BA, George MP, Bhama J, et al. Lung transplant in patients with scleroderma compared with pulmonary fibrosis. Short- and long-term outcomes. Ann Am Thorac Soc. 2016;13:784–92.CrossRefPubMed
8.
Chan EY, Goodarzi A, Sinha N, Nguyen DT, Youssef JG, Suarez EE, et al. Long-term survival in bilateral lung transplantation for scleroderma-related lung disease. Ann Thorac Surg. 2018;105:893–900.CrossRefPubMed
9.
Pradère P, Tudorache I, Magnusson J, Savale L, Brugiere O, Douvry B, et al. Lung transplantation for scleroderma lung disease: an international, multicenter, observational cohort study. J Heart Lung Transplant. 2018;37:903–11.CrossRefPubMed
10.
Zhang N, Liu S, Zhang Z, Liu Y, Mi L, Xu K. Lung transplantation: a viable option for connective tissue disease? Arthritis Care Res. 2023;75:2389–98.CrossRef
11.
The Japanese Respiratory Society Guideline for the Management of in Adults (2024) The Japanese Respiratory Society
12.
Renaud-Picard B, Koutsokera A, Cabanero M, Martinu T. Acute rejection in the modern lung transplant era. Semin Respir Crit Care Med. 2021;42:411–27.CrossRefPubMed
13.
Levine DJ, Glanville AR, Aboyoun C, Belperio J, Benden C, Berry GJ, et al. Antibody-mediated rejection of the lung: a consensus report of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2016;35:397–406.CrossRefPubMed
14.
15.
Verleden GM, Glanville AR, Lease ED, Fisher AJ, Calabrese F, Corris PA, et al. Chronic lung allograft dysfunction: definition, diagnostic criteria, and approaches to treatment-A consensus report from the Pulmonary Council of the ISHLT. J Heart Lung Transplant. 2019;38:493–503.CrossRefPubMed
16.
Snell GI, Yusen RD, Weill D, Strueber M, Garrity E, Reed A, et al. Report of the ISHLT working group on primary lung graft dysfunction, part I: definition and grading-A 2016 Consensus Group statement of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2017;36:1097–103.CrossRefPubMed
17.
Kanda Y. Investigation of the freely available easy-to-use software “EZR” for medical statistics. Bone Marrow Transplant. 2013;48:452–8.CrossRefPubMed
18.
Konishi Y, Miyoshi K, Kurosaki T, Otani S, Sugimoto S, Yamane M, et al. Airway bacteria of the recipient but not the donor are relevant to post-lung transplant pneumonia. Gen Thorac Cardiovasc Surg. 2020;68:833–40.CrossRefPubMed
19.
Courtwright AM, El-Chemaly S, Dellaripa PF, Goldberg HJ. Survival and outcomes after lung transplantation for non-scleroderma connective tissue-related interstitial lung disease. J Heart Lung Transplant. 2017;36:763–9.CrossRefPubMed
20.
Takagishi T, Ostrowski R, Alex C, Rychlik K, Pelletiere K, Tehrani R. Survival and extrapulmonary course of connective tissue disease after lung transplantation. J Clin Rheumatol Pract Rep Rheum Musculoskelet Dis. 2012;18:283–9.
21.
22.
Crespo MM, Lease ED, Sole A, Sandorfi N, Snyder LD, Berry GJ, et al. ISHLT consensus document on lung transplantation in patients with connective tissue disease: Part I: Epidemiology, assessment of extrapulmonary conditions, candidate evaluation, selection criteria, and pathology statements. J Heart Lung Transplant. 2021;40:1251–66.CrossRefPubMed
23.
Yang X, Wei D, Liu M, Wu B, Zhang J, Xu H, et al. Survival and outcomes after lung transplantation for connective tissue disease-associated interstitial lung diseases. Clin Rheumatol. 2021;40:3789–95.CrossRefPubMedPubMedCentral
24.
Nakayama Y, Nakashima R, Handa T, Ohsumi A, Yamada Y, Nakajima D, et al. Prognosis of patients with systemic sclerosis-related interstitial lung disease on the lung transplant waiting list: a retrospective study. Sci Rep. 2023;13:10150.CrossRefPubMedPubMedCentral
Metadata
Title
Post-lung transplant outcomes of connective tissue disease-related interstitial lung diseases compared with idiopathic interstitial pneumonia: a single-center experience in Japan
Authors
Miho Yamaguchi
Takafumi Yamaya
Mitsuaki Kawashima
Chihiro Konoeda
Hidenori Kage
Masaaki Sato
Publication date
06-09-2024
Publisher
Springer Nature Singapore
Published in
General Thoracic and Cardiovascular Surgery
Print ISSN: 1863-6705
Electronic ISSN: 1863-6713
DOI
https://doi.org/10.1007/s11748-024-02073-3
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