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Open Access 11-06-2024 | Pleural Mesothelioma | Case Report

Epithelioid pleural mesothelioma successfully treated with perioperative immunotherapy: a case report

Authors: Gaku Yamazaki, Aki Fujiwara-Kuroda, Jun Muto, Hideki Ujiie, Masato Aragaki, Megumi Furuta, Sakurako Ohno, Kanako C. Hatanaka, Yutaka Hatanaka, Yoshihiro Matsuno, Tatsuya Kato

Published in: General Thoracic and Cardiovascular Surgery Cases | Issue 1/2024

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Abstract

Background

Pleural mesothelioma, characterized by a dismal prognosis even with multimodal therapy, has seen emerging interest in immune checkpoint inhibitors (ICIs) due to their demonstrated efficacy. Here, we present a case of epithelioid-type pleural mesothelioma with chest wall invasion treated with definitive ICI therapy, resulting in a remarkable pretreatment effect.

Case presentation

A 46-year-old man was diagnosed with an abnormal chest shadow on a medical check, and a computed tomography scan showed pleural thickening at the dorsal right upper chest wall. One of the nodules was suspected to have invaded the chest wall. A needle biopsy revealed epithelioid-type pleural mesothelioma. After five cycles of nivolumab plus ipilimumab, he underwent right pleurectomy/decortication (P/D). Pathological examination revealed a significant treatment effect, showing numerous lymphocytes infiltrating the tumor nodule and viable tumor cells localized at approximately 6 mm.

Conclusion

Although further accumulation of cases is required to evaluate the effectiveness and case selection, P/D after immunotherapy is a useful curative treatment option for advanced pleural mesothelioma.
Literature
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go back to reference Kitajima K, Maruyama M, Yokoyama H, Minami T, Yokoi T, Nakamura A, et al. Response to immune checkpoint inhibitor therapy in patients with unresectable recurrent malignant pleural mesothelioma shown by FDG-PET and CT. Cancers (Basel). 2021;13(5). https://doi.org/10.3390/cancers13051098. PMID 33806464. Kitajima K, Maruyama M, Yokoyama H, Minami T, Yokoi T, Nakamura A, et al. Response to immune checkpoint inhibitor therapy in patients with unresectable recurrent malignant pleural mesothelioma shown by FDG-PET and CT. Cancers (Basel). 2021;13(5). https://​doi.​org/​10.​3390/​cancers13051098. PMID 33806464.
Metadata
Title
Epithelioid pleural mesothelioma successfully treated with perioperative immunotherapy: a case report
Authors
Gaku Yamazaki
Aki Fujiwara-Kuroda
Jun Muto
Hideki Ujiie
Masato Aragaki
Megumi Furuta
Sakurako Ohno
Kanako C. Hatanaka
Yutaka Hatanaka
Yoshihiro Matsuno
Tatsuya Kato
Publication date
11-06-2024
Publisher
BioMed Central
Published in
General Thoracic and Cardiovascular Surgery Cases / Issue 1/2024
Electronic ISSN: 2731-6203
DOI
https://doi.org/10.1186/s44215-024-00157-3

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