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BMC Pulmonary Medicine
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Open Access 01-12-2024 | Pityriasis Lichenoides Chronica | Research

Predicting solitary pulmonary lesions in breast cancer patients using 18fluorodeoxyglucose-positron emission tomography/computed tomography combined with clinicopathological characteristics

Authors: Yangyang Xue, Weishu Hou, Yanhui He, Alei Xu, Xiaohu Li

Published in: BMC Pulmonary Medicine | Issue 1/2024

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Abstract

Background

Solitary pulmonary nodules (SPNs) remain difficult to diagnose for clinical therapeutic purposes in patients with a history of breast cancer. This study try to investigate the value of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) combined with clinicopathological predictors for the differential diagnosis of SPNs in breast cancer patients.

Methods

One hundred and twenty breast cancer patients with newly detected SPNs were enrolled in the study and divided into a primary lung cancer (PLC) group and a breast cancer metastasis (BCM) group. The clinicopathological characteristics as well as metabolic and morphological characteristics on 18F-FDG-PET/CT images of 120 patients were retrospectively reviewed. The differences of clinicopathological and 18F-FDG-PET/CT characteristics between the two groups were analyzed, and multivariate analyses for the diagnosis of SPNs were performed.

Results

Clinicopathological terms of carcinoembryonic antigen (CEA) and CA15-3 levels exhibited significant differences between PLC and BCM groups (P = 0.005 and P = 0.001, respectively). Metabolic characteristics of 18F-FDG-PET/CT images included FDG uptake, SUVmax of SPNs, hilar and/or mediastinal lymph node metastasis, SUVmax of hilar and/or mediastinal lymph node, and extrapulmonary metastasis showed significant differences between PLC and BCM groups (P = 0.004, P < 0.001, P = 0.01, P = 0.032 and P = 0.023, respectively). The lobulation sign, spicule sign, and pleural indentation sign were identified as statistically different morphological features of PLC in CT images (all P < 0.001). Among these, the SUVmax of SPNs, lobulation sign, and pleural indentation sign were valuable predictive factors for accurate diagnosis of SPNs in breast cancer patients.

Conclusions

18F-FDG-PET/CT combined with serum tumor markers are valuable for the diagnosis of SPNs in breast cancer patients.
Literature
1.
Liang Y, Zhang H, Song X, Yang Q. Metastatic heterogeneity of breast cancer:molecular mechanism and potential therapeutic targets. Semin Cancer Biol. 2020;60:14–27.CrossRefPubMed
2.
3.
Mazzone PJ, Lam L. Evaluating the patient with a pulmonary nodule. Rev JAMA. 2022;327(3):264–73.CrossRef
4.
Zhao W, Song C, Zhu S, Song Z. Prognostic implication of isolated pulmonary nodules in patients with a history of breast cancer. J Cardiothorac Surg. 2022;17(1):160.CrossRefPubMedPubMedCentral
5.
Gilbert FJ, Harris S, Miles KA, Weir-McCall JR, Qureshi NR, Rintoul RC, et al. Comparative accuracy and cost-effectiveness of dynamic contrast-enhanced CT and positron emission tomography in the characterisation of solitary pulmonary nodules. Thorax. 2022;77(10):988–96.CrossRefPubMed
6.
7.
Spadafora M, Pace L, Evangelista L, Mansi L, Del Prete F, Saladini G, et al. Risk-related 18F-FDG PET/CT and new diagnostic strategies in patients with solitary pulmonary nodule: the ITALIAN multicenter trial. Eur J Nucl Med Mol Imaging. 2018;45(11):1908–14.CrossRefPubMed
8.
Erdoğan M, Evrimler Ş, Aydın H, Karaibrahimoğlu A, Şengül SS. Solitary pulmonary nodule: Morphological effects on metabolic activity Assessment. Mol Imaging Radionucl Ther. 2019;28(3):112–9.CrossRefPubMedPubMedCentral
9.
Zhu L, Bian H, Yang L, Liu J, Chen W, Li X, et al. Fluorodeoxyglucose-positron emission tomography/computed tomography features of suspected solitary pulmonary lesions in breast cancer patients following previous curative treatment. Thorac Cancer. 2019;18(5):1086–95.CrossRef
10.
Nasim F, Ost DE. Management of the solitary pulmonary nodule. Curr Opin Pulm Med. 2019;25(4):344–53.CrossRefPubMed
11.
Yu Y, Zhu J, Sang S, Yang Y, Zhang B, Deng S. Application of 18F-FDG PET/CT imaging radiomics in the differential diagnosis of single-nodule pulmonary metastases and second primary lung cancer in patients with colorectal cancer. J Cancer Res Ther. 2024;20(2):599–607.CrossRefPubMed
12.
Zhong M, Zhang Y, Pan Z, Wang W, Zhang Y, Weng Y, et al. Clinical utility of circulating Tumor cells in the early detection of Lung Cancer in patients with a Solitary Pulmonary Nodule. Technol Cancer Res Treat. 2021;20:15330338211041465.CrossRefPubMedPubMedCentral
13.
Wang W, Xu X, Tian B, Wang Y, Du L, Sun T, et al. The diagnostic value of serum tumor markers CEA, CA19-9, CA125, CA15-3, and TPS in metastatic breast cancer. Clin Chim Acta. 2017;470:51–5.CrossRefPubMed
14.
Maeda T, Hiraki M, Jin C, Rajabi H, Tagde A, Alam M, et al. MUC1-C induces PD-L1 and immune evasion in triple-negative breast cancer. Cancer Res. 2018;78(1):205–15.CrossRefPubMed
15.
16.
Gradishar WJ, Anderson BO, Balassanian R, Blair SL, Burstein HJ, Cyr A, et al. Invasive breast Cancer Version 1.2016, NCCN Clinical Practice guidelines in Oncology. J Natl Compr Cancer Netw. 2016;14(3):324–54.CrossRef
17.
Kanai R, Tane K, Ishii G, Suzuki J, Sakai T, Okada S, et al. Clinical prediction of solitary pulmonary nodule after a curative resection for gastric cancer. Jpn J Clin Oncol. 2018;48(12):1083–7.CrossRefPubMed
18.
Kinoshita T, Yoshida J, Ishii G, Hishida T, Wada M, Aokage K, et al. The availability of preand intraoperative evaluation of a solitary pulmonary nodule in breast cancer patients. Ann Thorac Cardiovasc Surg. 2015;21(1):31–6.CrossRefPubMed
19.
Shao X, Niu R, Shao X, Jiang Z, Wang Y. Value of 18F-FDG PET/CT-based radiomics model to distinguish the growth patterns of early invasive lung adenocarcinoma manifesting as ground-glass opacity nodules. EJNMMI Res. 2020;10(1):80.CrossRefPubMedPubMedCentral
20.
Huang Y, Jiang X, Xu H, Zhang D, Liu LN, Xia YX, et al. Preoperative prediction of mediastinal lymph node metastasis in non-small cell lung cancer based on 18F-FDG PET/CT radiomics. Clin Radiol. 2023;78(1):8–17.CrossRefPubMed
21.
Hino H, Utsumi T, Maru N, Matsui H, Taniguchi Y, Saito T, et al. Clinical impact and utility of positron emission tomography on occult lymph node metastasis and survival: radical surgery for stage I lung cancer. Gen Thorac Cardiovasc Surg. 2021;69(8):1196–203.CrossRefPubMed
22.
Chang JM, Leung JWT, Moy L, Ha SM, Moon WK. Axillary nodal evaluation in breast Cancer: state of the art. Radiology. 2020;295(3):500–15.CrossRefPubMed
23.
Kim M, Chung YS, Kim KA, Shim HS. Prognostic factors of acinar- or papillary-predominant adenocarcinoma of the lung. Lung Cancer. 2019;137:129–35.CrossRefPubMed
24.
Li L, Zhou X, Cui W, Liu T, Yuan G, Peng Y, et al. Combining radiomics and deep learning features of intra-tumoral and peri-tumoral regions for the classification of breast cancer lung metastasis and primary lung cancer with low-dose CT. J Cancer Res Clin Oncol. 2023;149(17):15469–78.CrossRefPubMed
25.
Cha MJ, Lee KS, Kim TJ, Kim HS, Kim TS, Chung MJ, et al. Solitary nodular invasive mucinous adenocarcinoma of the lung: imaging diagnosis using the morphologic-metabolic dissociation sign. Korean J Radiol. 2019;20(3):513–21.CrossRefPubMedPubMedCentral
26.
Li Y, Wang T, Fu YF, Shi YB. Computed tomography-based spiculated sign for prediction of malignancy in lung nodules: a meta-analysis. Clin Respir J. 2020;14(12):1113–21.CrossRefPubMed
27.
Moon Y, Sung SW, Lee KY, Sim SB, Park JK. Pure ground-glass opacity on chest computed tomography: predictive factors for invasive adenocarcinoma. J Thorac Dis. 2016;8(7):1561–70.CrossRefPubMedPubMedCentral
28.
Basse C, Ancel J, Massiani MA, Bonté PE, Beaulaton C, Beaucaire-Danel S. Et L. Accelerated subsequent lung cancer after post-operative radiotherapy for breast cancer. Lung Cancer. 2023;182:107295.CrossRefPubMed
29.
Smida T, Bruno TC, Stabile LP. Influence of estrogen on the NSCLC microenvironment: a comprehensive picture and clinical implications[J]. Front Oncol. 2020;10:137.CrossRefPubMedPubMedCentral
30.
Wang Y, Song W, Zhou S, Chang S, Chang J, Tian J, Zhang L, Li J, Che G. The genomic and transcriptome characteristics of lung adenocarcinoma patients with previous breast cancer. BMC Cancer. 2022;22(1):618.CrossRefPubMedPubMedCentral
Metadata
Title
Predicting solitary pulmonary lesions in breast cancer patients using 18fluorodeoxyglucose-positron emission tomography/computed tomography combined with clinicopathological characteristics
Authors
Yangyang Xue
Weishu Hou
Yanhui He
Alei Xu
Xiaohu Li
Publication date
01-12-2024

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