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27-09-2024 | Pharmacokinetics | Editorial

The concept of “fictitious weight” in pharmacokinetic simulations and target-controlled infusion

Author: Shinju Obara

Published in: Journal of Anesthesia

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Excerpt

Zhong and Xu recently published a paper titled “General Purpose Propofol Target-Controlled Infusion Using the Marsh Model with Adjusted Weight Input” in Journal of Anesthesia [1]. This study aimed to improve the performance of target-controlled infusion (TCI) in adjusting the gap between predicted propofol concentrations and actual plasma levels. This improvement is achieved by mimicking the TCI behavior of the Eleveld model [2], which is currently considered the best model, through modifying the input weight in the Marsh model. The Marsh model is adopted by the Diprifusor system [3, 4], the only TCI system available in Japan. To understand the concept of Zhong and Xu’s study, it is essential to understand the foundational principles regarding how patient characteristics influence the pharmacokinetics (PK) of commonly used anesthetic drugs, and consequently, their impact on PK simulations and the predictive performance of TCI. This paper explains these concepts using propofol as the primary example, and also provides supplementary information on remifentanil and fentanyl. …
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Metadata
Title
The concept of “fictitious weight” in pharmacokinetic simulations and target-controlled infusion
Author
Shinju Obara
Publication date
27-09-2024
Publisher
Springer Nature Singapore
Published in
Journal of Anesthesia
Print ISSN: 0913-8668
Electronic ISSN: 1438-8359
DOI
https://doi.org/10.1007/s00540-024-03413-6