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29-01-2025 | Peritoneal Dialysis | Clinical Insights

Improvement of lactic acidosis in pyruvate dehydrogenase complex deficiency using custom-made amino acid–based dialysate for peritoneal dialysis

Authors: Manson Chon In Kuok, Chi Kwan Jasmine Chow, Ngai Man Chan, Winnie Kwai Yu Chan

Published in: Pediatric Nephrology

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Abstract

This case report presents a newborn with pyruvate dehydrogenase complex deficiency who developed significant lactic acidosis and acute kidney injury after birth. Peritoneal dialysis with glucose-based peritoneal dialysis fluid was initially started, but the patient had worsening hyperglycemia and lactic acidosis, likely related to excess glucose reabsorption with shunting to lactate due to the underlying metabolic disorder. As amino acid–based dialysis solution was not available in our formulary, a dialysis fluid was manually created with Vaminolact, which was commonly used in neonatal parenteral nutrition. Switching to the new dialysis fluid led to significant biochemical improvement.
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Metadata
Title
Improvement of lactic acidosis in pyruvate dehydrogenase complex deficiency using custom-made amino acid–based dialysate for peritoneal dialysis
Authors
Manson Chon In Kuok
Chi Kwan Jasmine Chow
Ngai Man Chan
Winnie Kwai Yu Chan
Publication date
29-01-2025
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-025-06679-4

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