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Annals of Surgical Oncology
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07-12-2024 | Peritoneal Cancer | ASO Author Reflections

ASO Author Reflections: What are the Prognostic Factors for Achieving Long-Term Survival in MPM Patients Treated with CRS+HIPEC? Does the Conditional Survival Analysis Provide Special Information?

Authors: Xin-Li Liang, MD, Yan Li, MD, PhD

Published in: Annals of Surgical Oncology | Issue 4/2025

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Excerpt

Cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has been identified as the preferred treatment for selected patients with malignant peritoneal mesothelioma (MPM). Many institutions have reported that CRS+HIPEC is associated with long-term survival (LTS) of MPM,1 and some patients can survive for a considerable time or even clinical cure. At present, many clinical studies have focused on MPM patients with LTS and explored the survival benefit factors in this population. For example, Alexander et al.2 retrospectively analyzed 211 MPM patients who underwent CRS+HIPEC and showed that the following four factors were independently associated with a good prognosis: age < 60 years, complete or near-complete resection, low histological grade, and the use of cisplatin in the HIPEC regimen. …
Literature
1.
Turner K, Varghese S, Alexander HR Jr. Current concepts in the evaluation and treatment of patients with diffuse malignant peritoneal mesothelioma. J Natl Compr Canc Netw. 2012;10(1):49–57.CrossRefPubMed
2.
Alexander HR Jr, Bartlett DL, Pingpank JF, et al. Treatment factors associated with long-term survival after cytoreductive surgery and regional chemotherapy for patients with malignant peritoneal mesothelioma. Surgery. 2013;153(6):779–86.CrossRefPubMed
3.
Han L, Dai W, Mo S, et al. Nomogram of conditional survival probability of long-term survival for metastatic colorectal cancer: a real-world data retrospective cohort study from SEER database. Int J Surg. 2021;92:106013.CrossRefPubMed
4.
Beal EW, Srinivas S, Shen C, et al. Conditional survival following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for peritoneal surface malignancies: an analysis from the US HIPEC collaborative. Ann Surg Oncol. 2023;30(3):1840–9.CrossRefPubMed
5.
Metadata
Title
ASO Author Reflections: What are the Prognostic Factors for Achieving Long-Term Survival in MPM Patients Treated with CRS+HIPEC? Does the Conditional Survival Analysis Provide Special Information?
Authors
Xin-Li Liang, MD
Yan Li, MD, PhD
Publication date
07-12-2024
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 4/2025
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-024-16681-z

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