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21-09-2023 | Peripheral Nervous System Disease | Review Article

Assessment of comorbid symptoms in pediatric autonomic dysfunction

Authors: Sally E. Tarbell, Erin L. Olufs, Philip R. Fischer, Gisela Chelimsky, Mohammed T. Numan, Marvin Medow, Hasan Abdallah, Shelley Ahrens, Jeffrey R. Boris, Ian J. Butler, Thomas C. Chelimsky, Craig Coleby, John E. Fortunato, Raewyn Gavin, Janice Gilden, Renato Gonik, Kelsey Klaas, Lauren Marsillio, Erin Marriott, Laura A. Pace, Paul Pianosi, Pippa Simpson, Julian Stewart, Natalie Van Waning, Debra E. Weese-Mayer

Published in: Clinical Autonomic Research | Issue 6/2023

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Abstract

Purpose

Pediatric patients with autonomic dysfunction and orthostatic intolerance (OI) often present with co-existing symptoms and signs that might or might not directly relate to the autonomic nervous system. Our objective was to identify validated screening instruments to characterize these comorbidities and their impact on youth functioning.

Methods

The Pediatric Assembly of the American Autonomic Society reviewed the current state of practice for identifying symptom comorbidities in youth with OI. The assembly includes physicians, physician-scientists, scientists, advanced practice providers, psychologists, and a statistician with expertise in pediatric disorders of OI. A total of 26 representatives from the various specialties engaged in iterative meetings to: (1) identify and then develop consensus on the symptoms to be assessed, (2) establish committees to review the literature for screening measures by member expertise, and (3) delineate the specific criteria for systematically evaluating the measures and for making measure recommendations by symptom domains.

Results

We review the measures evaluated and recommend one measure per system/concern so that assessment results from unrelated clinical centers are comparable. We have created a repository to apprise investigators of validated, vetted assessment tools to enhance comparisons across cohorts of youth with autonomic dysfunction and OI.

Conclusion

This effort can facilitate collaboration among clinical settings to advance the science and clinical treatment of these youth. This effort is essential to improving management of these vulnerable patients as well as to comparing research findings from different centers.
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Metadata
Title
Assessment of comorbid symptoms in pediatric autonomic dysfunction
Authors
Sally E. Tarbell
Erin L. Olufs
Philip R. Fischer
Gisela Chelimsky
Mohammed T. Numan
Marvin Medow
Hasan Abdallah
Shelley Ahrens
Jeffrey R. Boris
Ian J. Butler
Thomas C. Chelimsky
Craig Coleby
John E. Fortunato
Raewyn Gavin
Janice Gilden
Renato Gonik
Kelsey Klaas
Lauren Marsillio
Erin Marriott
Laura A. Pace
Paul Pianosi
Pippa Simpson
Julian Stewart
Natalie Van Waning
Debra E. Weese-Mayer
Publication date
21-09-2023
Publisher
Springer Berlin Heidelberg
Published in
Clinical Autonomic Research / Issue 6/2023
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-023-00984-4

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