Lupus pneumonitis in neonatal lupus: a case report
- Open Access
- 08-10-2025
- Pediatric Rheumatology
- Case report
Published in:
- Authors
- Naram Khalayli
- Lama Al-Darwish
- Maria Suleiman
- Ahmad Alhaj
- Maysoun Kudsi
- Bassel Salman
- Riham Suleiman
- Published in
- Journal of Medical Case Reports | Issue 1/2025
Abstract
Background
Neonatal lupus is a rare autoimmune condition caused by the transplacental passage of maternal autoantibodies, most commonly from mothers with systemic lupus erythematosus. While cutaneous and cardiac involvement are well recognized, respiratory manifestations—particularly acute lupus pneumonitis—are extremely rare, with very few documented cases in neonates.
Case presentation
We describe a preterm neonate of Middle Eastern ethnicity born at 34 weeks gestation to a mother with systemic lupus erythematosus who presented with erythematous skin lesions and progressive respiratory distress. The initial suspicion was neonatal sepsis, but further imaging revealed bilateral ground-glass opacities suggestive of pneumonitis. The diagnosis of acute lupus pneumonitis was considered. The patient was treated with intravenous immunoglobulin and corticosteroids, resulting in significant clinical improvement.
Conclusion
This case highlights the importance of considering acute lupus pneumonitis in neonates with unexplained respiratory failure, especially when maternal autoimmune disease is present. Early recognition and immunosuppressive therapy can lead to favorable outcomes.
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- Title
- Lupus pneumonitis in neonatal lupus: a case report
- Authors
-
Naram Khalayli
Lama Al-Darwish
Maria Suleiman
Ahmad Alhaj
Maysoun Kudsi
Bassel Salman
Riham Suleiman
- Publication date
- 08-10-2025
- Publisher
- BioMed Central
- Published in
-
Journal of Medical Case Reports / Issue 1/2025
Electronic ISSN: 1752-1947 - DOI
- https://doi.org/10.1186/s13256-025-05532-4
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