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Open Access 18-12-2023 | Pathology | REVIEW AND PERSPECTIVES

Molecular pathology of endocrine gland tumors: genetic alterations and clinicopathologic relevance

Authors: Antonio De Leo, Martina Ruscelli, Thais Maloberti, Sara Coluccelli, Andrea Repaci, Dario de Biase, Giovanni Tallini

Published in: Virchows Archiv | Issue 2/2024

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Abstract

Tumors of the endocrine glands are common. Knowledge of their molecular pathology has greatly advanced in the recent past. This review covers the main molecular alterations of tumors of the anterior pituitary, thyroid and parathyroid glands, adrenal cortex, and adrenal medulla and paraganglia. All endocrine gland tumors enjoy a robust correlation between genotype and phenotype. High-throughput molecular analysis demonstrates that endocrine gland tumors can be grouped into molecular groups that are relevant from both pathologic and clinical point of views. In this review, genetic alterations have been discussed and tabulated with respect to their molecular pathogenetic role and clinicopathologic implications, addressing the use of molecular biomarkers for the purpose of diagnosis and prognosis and predicting response to molecular therapy. Hereditary conditions that play a key role in determining predisposition to many types of endocrine tumors are also discussed.
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Metadata
Title
Molecular pathology of endocrine gland tumors: genetic alterations and clinicopathologic relevance
Authors
Antonio De Leo
Martina Ruscelli
Thais Maloberti
Sara Coluccelli
Andrea Repaci
Dario de Biase
Giovanni Tallini
Publication date
18-12-2023
Publisher
Springer Berlin Heidelberg
Published in
Virchows Archiv / Issue 2/2024
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-023-03713-4

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