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Pathology

A practical approach to lung ultrasound

A comprehensive guide to point-of care ultrasound of the lungs, taking you through the basic physics, a hands-on scanning technique, and what you can expect to see in a normal exam as well as in various pathological conditions.

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Editor's Choice

Key tests for diagnosing pLGG

Detailed pathological diagnosis – based on a combination of histology, methylation profiling, and sequencing – provides the optimal basis for deciding how to treat pediatric low-grade gliomas.

Ablation of thyroid cancer: a double-edged sword?

Thyroid ablation technology has developed rapidly in the past 20 years, but these two cases highlight how incomplete ablation of thyroid nodules hinders its use as a treatment for thyroid cancer.

Differentiating prodromal dementia: DLB vs AD

Overlapping clinical phenotypes make diagnosis challenging in patients with mild cognitive impairment. What clinical and biological features can help characterize dementia with Lewy bodies versus Alzheimer's disease?

Biomarkers for dementia with Lewy bodies

DLB remains underdiagnosed due to its clinical and pathological heterogeneity, but emerging diagnostic and prognostic biomarkers could herald a new age of precision medicine.

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Case Studies

Ablation of thyroid cancer: a double-edged sword?

Thyroid ablation technology has developed rapidly in the past 20 years, but these two cases highlight how incomplete ablation of thyroid nodules hinders its use as a treatment for thyroid cancer.

Aortic arch pathology with a shaggy aorta

Co-presentation of aortic aneurysms and a shaggy aorta carry catastrophic risks of brain infarction and spinal cord injury. Follow the surgical approach taken in this high-risk case.

Vocal cord paralysis caused by metastasized endometrial cancer

The first case of vocal cord paralysis due to a mediastinal metastasis developing 16 years after the patient's endometrial cancer was treated by hysterectomy, external beam radiotherapy, and chemotherapy.

Current Reviews

Intergroup statement: opportunistic salpingectomy—molecular pathology, clinical outcomes and implications for practice (German Ovarian Cancer Commission, the North-Eastern German Society of Gynecologic Oncology (NOGGO), AGO Austria and AGO Swiss)

Opportunistic salpingectomy is defined as the removal of both fallopian tubes as part of a surgical procedure planned for other reasons. The goal is primary prevention of ovarian cancer. The procedure is offered to patients who are not known to be …

Alzheimer mimicry: LATE and PART

  • Open Access
  • Alzheimer's Disease
  • Neurology and Preclinical Neurological Studies - Review Article

Alzheimer’s disease (AD) is the main cause of dementia and accounts for 60% of dementia syndromes in people older than 75 years. The correct classification of AD and non-AD cases is mandatory to study disease mechanisms or new treatment …

Dark side of the shoulder: suprascapular and axillary nerve compressions

Suprascapular nerve pathologies are becoming widely acknowledged as a source of shoulder pain. The unique anatomy of nerve exposes it to both dynamic and static compression, as well as direct trauma [ 4 ]. The earliest studies on suprascapular …

Biomarkers in gastroesophageal cancer 2025: an updated consensus statement by the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathology (SEAP)

Gastroesophageal carcinomas, including gastroesophageal adenocarcinoma (GEA) and esophageal squamous cell carcinoma (ESCC), pose a global health challenge due to their heterogeneity. The approach to diagnosis and treatment should first …

Further Reading

Postmortem morphology of honeybee stings induced fatal anaphylaxis

Despite numerous case reports in the literature, high-quality postmortem images of honeybee sting are scant in postmortem literature. We report a case of a fatal anaphylactic death from honeybee stings with detailed high-quality annotated …

Digitally quantified area of residual tumor after neoadjuvant chemotherapy in HER2-positive breast cancer

The standard treatment for human epidermal growth factor receptor 2 (HER2)-positive early breast cancer involves a combination of surgery, chemotherapy with anti-HER2 therapy, and radiation therapy. Historically, chemotherapy was administered as …

Intergroup statement: opportunistic salpingectomy—molecular pathology, clinical outcomes and implications for practice (German Ovarian Cancer Commission, the North-Eastern German Society of Gynecologic Oncology (NOGGO), AGO Austria and AGO Swiss)

Opportunistic salpingectomy is defined as the removal of both fallopian tubes as part of a surgical procedure planned for other reasons. The goal is primary prevention of ovarian cancer. The procedure is offered to patients who are not known to be …

Cerebellar dysfunction in frontotemporal dementia: intra-cerebellar pathology and cerebellar network degeneration

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) form part of the same disease spectrum with shared clinical, imaging, and genetic features [ 1 – 3 ]. There are distinct clinical phenotypes along the ALS-FTD continuum with …