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01-12-2024 | Parotidectomy | Review

Salivary Gland Oncocytomas. A Systematic Review

Authors: Peraza Labrador Alberto, Shrestha Ashim, Koch Megan, Zhang Wei, Gonzalez Nestor, Zhou Matthew, Mamani Dayana, Villacis Marcelo, Wright John

Published in: Head and Neck Pathology | Issue 1/2024

Abstract

Background

Oncocytoma is a primary benign epithelial neoplasm comprising less than 2% of salivary tumors with a low recurrence rate.

Methods

A systematic review of documented case reports and case series of oncocytomas is presented. Searches from different databases were performed to identify articles from 1956 to 2024. The variables included were gender, age, symptoms, duration time before diagnosis, type of gland, histological features, special or immunohistochemical evaluation, treatment, follow-up, recurrence, and relation with a medical condition or syndrome.

Results

Of the 147 cases reported, 53.1% affected females, and 46.9% were in males. The average age was 58.7 years, and the mean size was 2.3 cm. The most common clinical presentation was swelling (92.6%) and 66.7% were asymptomatic. The parotid was the most commonly affected gland with 66% of cases, the submandibular gland with 23.3%, and the minor salivary glands with Phosphotungstic acid-hematoxylin (PTAH) was the most common special stain used in 36.7%, followed by a combination with Periodic acid-Schiff (PAS) with and without diastase in 26.6%. Excisional biopsy was the most common treatment in 38.1% followed by superficial parotidectomy in 32.7%. Follow-up was 34.7 months on average. Bilateral oncocytomas were found in 4.8% with a 6 to 1 female-male proportion. Recurrence was found in 2.7% and association with Birt-Hogg-Dube (BHD) syndrome was 8.2%.

Conclusion

Salivary oncocytoma is a rare epithelial neoplasm with nonspecific clinical presentations. Diagnosis can be suspected on cytology and confirmed by histologic examination. The lesion has an indolent clinical course and most of the reported cases did not recur. There seems to be an association between bilateral oncocytomas and females and a low but interesting association with BHD. Overall, this review serves to better highlight the features of this rare benign neoplasm.

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Title: Salivary Gland Oncocytomas. A Systematic Review
Authors: Peraza Labrador Alberto
Shrestha Ashim
Koch Megan
Zhang Wei
Gonzalez Nestor
Zhou Matthew
Mamani Dayana
Villacis Marcelo
Wright John
Publication date: 01-12-2024
Publisher: Springer US
Keyword: Parotidectomy
Published in: Head and Neck Pathology / Issue 1/2024
Electronic ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-024-01730-6

Tyrosine-Like Crystalloids Localize to Non-Neoplastic True Vocal Cord and Attachments

Laryngectomy
Research

Sinonasal Differentiated Papillary NUT Carcinoma

Human Papillomavirus
Correspondence

CLIC4 Function in the Epithelial-Mesenchymal Transition of Epithelial Odontogenic Lesions

Ameloblastoma
Research

Deep Convolutional Neural Network for Accurate Classification of Myofibroblastic Lesions on Patch-Based Images

Artificial Intelligence
Research

Ectomesenchymal Chondromyxoid Tumor of the Anterior Tongue: A Case Image

Soft Tissue Tumor
Image

Malignant Recurrence of Benign Odontogenic Tumors (A Single Center Cross-Sectional Study)

Open Access
Ameloblastoma
Research

Keynote series | Spotlight on menopause

Springer Medicine

Salivary Gland Oncocytomas. A Systematic Review

Abstract

Background

Methods

Results

Conclusion

Other articles of this Issue 1/2024

Tyrosine-Like Crystalloids Localize to Non-Neoplastic True Vocal Cord and Attachments

Sinonasal Differentiated Papillary NUT Carcinoma

CLIC4 Function in the Epithelial-Mesenchymal Transition of Epithelial Odontogenic Lesions

Deep Convolutional Neural Network for Accurate Classification of Myofibroblastic Lesions on Patch-Based Images

Ectomesenchymal Chondromyxoid Tumor of the Anterior Tongue: A Case Image

Malignant Recurrence of Benign Odontogenic Tumors (A Single Center Cross-Sectional Study)

Keynote series | Spotlight on menopause

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Abstract

Background

Methods

Results

Conclusion

Please log in to get access to this content

Tyrosine-Like Crystalloids Localize to Non-Neoplastic True Vocal Cord and Attachments

Sinonasal Differentiated Papillary NUT Carcinoma

CLIC4 Function in the Epithelial-Mesenchymal Transition of Epithelial Odontogenic Lesions

Deep Convolutional Neural Network for Accurate Classification of Myofibroblastic Lesions on Patch-Based Images

Ectomesenchymal Chondromyxoid Tumor of the Anterior Tongue: A Case Image

Malignant Recurrence of Benign Odontogenic Tumors (A Single Center Cross-Sectional Study)