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Published in: Journal of Neurology 4/2023

21-01-2023 | Parkinson's Disease | Original Communication

Loss of torsional quick eye movements during head roll in progressive supranuclear palsy: a new diagnostic marker

Authors: Xia Ling, Hyo-Jung Kim, Jong-Hee Lee, Seonkyung Lee, Jeong-Yoon Choi, Li-Qun Zhong, Xu Yang, Ji-Soo Kim

Published in: Journal of Neurology | Issue 4/2023

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Abstract

Background and objectives

Even though impaired horizontal and vertical saccades are well-known features of progressive supranuclear palsy (PSP), abnormalities of torsional quick phases of eye movements have not been defined in PSP and other Parkinsonian syndromes. This study aims to determine the diagnostic value of decreased torsional quick phases during head oscillations in the roll plane in patients with PSP.

Methods

Using video-oculography, we recorded the head and eye motion during passive head oscillations in the roll plane and determined the decrease of torsional quick phases in patients with PSP (n = 13) in comparison to normal controls (n = 13) and those with multiple system atrophy (MSA, n = 17) or idiopathic Parkinson’s disease (PD, n = 6).

Results

Torsional quick phases were absent during the torsional vestibulo-ocular reflex (VOR) in 78.6% (11/13) of the patients with PSP, but only in 11.8% (2/17) of those with MSA and none with idiopathic PD or of normal controls (Chi-square tests, p < 0.001) while gains of the torsional VOR did not differ among the groups (Chi-square tests, p > 0.05). Furthermore, the torsional quick phases were smaller even when observed in patients with PSP.

Conclusion

Loss of torsional quick phases is an early biological marker for diagnosis of PSP, and may be ascribed to degeneration of the rostral interstitial nucleus of the medial longitudinal fasciculus that contains the burst neurons for torsional as well as vertical saccades.
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Metadata
Title
Loss of torsional quick eye movements during head roll in progressive supranuclear palsy: a new diagnostic marker
Authors
Xia Ling
Hyo-Jung Kim
Jong-Hee Lee
Seonkyung Lee
Jeong-Yoon Choi
Li-Qun Zhong
Xu Yang
Ji-Soo Kim
Publication date
21-01-2023
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 4/2023
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-023-11578-5

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