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Open Access 17-06-2024 | Parkinson's Disease | Original Article

Connectivity based on glucose dynamics reveals exaggerated sensorimotor network coupling on subject-level in Parkinson’s disease

Authors: Marina C. Ruppert-Junck, Vanessa Heinecke, Damiano Librizzi, Kenan Steidel, Maya Beckersjürgen, Frederik A. Verburg, Tino Schurrat, Markus Luster, Hans-Helge Müller, Lars Timmermann, Carsten Eggers, David Pedrosa

Published in: European Journal of Nuclear Medicine and Molecular Imaging

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Abstract

Purpose

While fMRI provides information on the temporal changes in blood oxygenation, 2- [18F]fluoro-2-deoxy-D-glucose ([18F]FDG)-PET has traditionally offered a static snapshot of brain glucose consumption. As a result, studies investigating metabolic brain networks as potential biomarkers for neurodegeneration have primarily been conducted at the group level. However, recent pioneering studies introduced time-resolved [18F]FDG-PET with constant infusion, which enables metabolic connectivity studies at the individual level.

Methods

In the current study, this technique was employed to explore Parkinson’s disease (PD)-related alterations in individual metabolic connectivity, in comparison to inter-subject measures and hemodynamic connectivity. Fifteen PD patients and 14 healthy controls with comparable cognition underwent sequential resting-state dynamic PET with constant infusion and functional MRI. Intrinsic networks were identified by independent component analysis and interregional connectivity calculated for summed static PET images, PET time series and functional MRI.

Results

Our findings revealed an intrinsic sensorimotor network in PD patients that has not been previously observed to this extent. In PD, a significantly higher number of connections in cortical motor areas was observed compared to elderly control subjects, as indicated by both static PET and functional MRI (pBonferroni−Holm = 0.027), as well as constant infusion PET and functional MRI connectomes (pBonferroni−Holm = 0.012). This intensified coupling was associated with disease severity (ρ = 0.56, p = 0.036).

Conclusion

Metabolic connectivity, as revealed by both static and dynamic PET, provides unique information on metabolic network activity. Subject-level metabolic connectivity based on constant infusion PET may serve as a potential marker for the metabolic network signature in neurodegeneration.
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Metadata
Title
Connectivity based on glucose dynamics reveals exaggerated sensorimotor network coupling on subject-level in Parkinson’s disease
Authors
Marina C. Ruppert-Junck
Vanessa Heinecke
Damiano Librizzi
Kenan Steidel
Maya Beckersjürgen
Frederik A. Verburg
Tino Schurrat
Markus Luster
Hans-Helge Müller
Lars Timmermann
Carsten Eggers
David Pedrosa
Publication date
17-06-2024
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nuclear Medicine and Molecular Imaging
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-024-06796-6