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11-04-2025 | Paraneoplastic Cerebellar Degeneration | Review

Imaging in paraneoplastic neurological syndromes: a comprehensive review

Authors: Ebinesh Arulnathan, Sathyashree, Praislin Gideon, M. Lokesh, K. Rajiv Gandhi

Published in: Japanese Journal of Radiology

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Abstract

Paraneoplastic neurological syndromes (PNS) are a complex spectrum of clinical syndromes that are associated with underlying malignancies. Majorly being immune-mediated, these syndromes are characterized by the presence of specific paraneoplastic antibodies that are either directed against intracellular (onconeuronal) or extracellular (surface or junctional) antigens. Syndromes associated with the occurrence of onconeuronal antibodies have poor prognoses. The spectrum of neurological manifestations includes limbic encephalitis, paraneoplastic cerebellar degeneration, rhombencephalitis, myelitis, optic neuropathy, cranial neuropathies, plexopathy and polyneuropathy. This review presents a comprehensive overview of these manifestations including their imaging features, associated malignancies and antibodies, differential diagnoses and recommended further evaluation.
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Metadata
Title
Imaging in paraneoplastic neurological syndromes: a comprehensive review
Authors
Ebinesh Arulnathan
Sathyashree
Praislin Gideon
M. Lokesh
K. Rajiv Gandhi
Publication date
11-04-2025
Publisher
Springer Nature Singapore
Published in
Japanese Journal of Radiology
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-025-01783-9