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29-01-2025 | Pancreatoduodenostomy | Review Article

Perioperative outcomes of robotic vs laparoscopic pancreatoduodenectomy: a meta-analysis and trial sequential analysis

Authors: Cecilio Armengol-García, Valeria Blandin-Alvarez, Eshita Sharma, Luis Eduardo Salinas-Ruiz, Marla L. González-Méndez, Mateus Monteiro dos Santos, Iqbal Farhan-Sayudo, Ana Carolina Ventura de Santana de Jesus, Aisha Rizwan-Ahmed, Eduardo Flores-Villalba

Published in: Surgical Endoscopy

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Abstract

Background

Minimally invasive pancreatoduodenectomy has gained widespread acceptance among hepatopancreatobiliary surgeons due to its demonstrated advantages in perioperative outcomes compared to the conventional open approach. This meta-analysis, along with trial sequential analysis, aimed to compare the outcomes of robotic pancreatoduodenectomy and laparoscopic pancreatoduodenectomy based on the current available evidence.

Methods

A systematic search of PubMed, Cochrane, Scopus, and Web of Science was conducted from inception to July 2024. We assessed intraoperative and postoperative outcomes, including open conversion rates, readmission, reoperation, and mortality. Additional factors, such as blood loss and the number of lymph nodes resected, were also evaluated. Quality assessment was performed using Cochrane’s risk of bias tools. Subgroup analysis was conducted based on propensity score matching status, and trial sequential analysis was applied to statistically significant results on first analysis.

Results

We meta-analyzed seventeen studies, with a total of 5,483 patients. The meta-analysis reported lower rates of open conversion (OR 0.40; 95% CI 0.26–0.61; p = < 0.001) and a higher number of lymph nodes resected (MD 3.5; 95% CI 1.45–5.55; p = 0.0008) in the RPD group. These results remained consistent after subgroup analysis. Trial sequential analysis confirmed true positive results, indicating that further studies are unnecessary to detect a significant difference. However, other perioperative outcomes did not show statistical significance and failed to reach the required information size for definitive conclusions.

Conclusion

This meta-analysis of non-randomized cohorts found lower rates of open conversion and a higher number of lymph nodes resected in patients undergoing robotic pancreatoduodenectomy. However, the initial analysis did not reveal statistically significant differences in transfusion rates, multivisceral and vascular resections, hemorrhage, delayed gastric emptying, mortality, or readmission rates. Future studies should focus on randomized designs, target more specific populations, and include long-term outcomes for a more comprehensive analysis.
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Literature
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go back to reference Kim H, Choi SH, Jang JY, Choi M, Lee JH, Kang CM (2022) Multicenter comparison of totally laparoscopic and totally robotic pancreaticoduodenectomy: propensity score and learning curve-matching analyses. J Hepato-Biliary-Pancreat Sci 29(3):311–321. https://doi.org/10.1002/jhbp.1078CrossRef Kim H, Choi SH, Jang JY, Choi M, Lee JH, Kang CM (2022) Multicenter comparison of totally laparoscopic and totally robotic pancreaticoduodenectomy: propensity score and learning curve-matching analyses. J Hepato-Biliary-Pancreat Sci 29(3):311–321. https://​doi.​org/​10.​1002/​jhbp.​1078CrossRef
Metadata
Title
Perioperative outcomes of robotic vs laparoscopic pancreatoduodenectomy: a meta-analysis and trial sequential analysis
Authors
Cecilio Armengol-García
Valeria Blandin-Alvarez
Eshita Sharma
Luis Eduardo Salinas-Ruiz
Marla L. González-Méndez
Mateus Monteiro dos Santos
Iqbal Farhan-Sayudo
Ana Carolina Ventura de Santana de Jesus
Aisha Rizwan-Ahmed
Eduardo Flores-Villalba
Publication date
29-01-2025
Publisher
Springer US
Published in
Surgical Endoscopy
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-024-11515-1
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