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Mitochondria-targeted strategies for acute pancreatitis

Mitochondrial dysfunction is an early and pivotal event in acute pancreatitis. Could mitochondria represent an attractive target for therapeutic intervention and how might mitochondria-directed strategies work?

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Editor's Choice

Immediate high-energy nutrition may increase adverse outcomes in acute pancreatitis

The GOULASH study finds no justification for a high-energy approach to early nutrition in patients with acute pancreatitis.

Pancreatic cancer or isolated pancreatic sarcoidosis?

Acute pancreatitis was diagnosed in a woman who presented with abdominal pain. Imaging raised suspicion for obstructive pancreatitis secondary to pancreatic cancer, but later investigations revealed a more unusual cause.

Duodenal biopsy gone bad

Hematoma, obstruction, and hemoperitoneum in a 25-year-old man admitted to the emergency department for mild abdominal pain and vomiting episodes 2 days after EGD with biopsy for suspected celiac disease.

ERCP fails to reduce acute pancreatis risk linked to congenital duct anomaly

Endoscopic retrograde cholangiopancreatography with minor papillotomy does not reduce recurrent acute pancreatitis risk in patients with pancreas divisum versus sham surgery.

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Case Studies

Pancreatic cancer or isolated pancreatic sarcoidosis?

Acute pancreatitis was diagnosed in a woman who presented with abdominal pain. Imaging raised suspicion for obstructive pancreatitis secondary to pancreatic cancer, but later investigations revealed a more unusual cause.

Duodenal biopsy gone bad

Hematoma, obstruction, and hemoperitoneum in a 25-year-old man admitted to the emergency department for mild abdominal pain and vomiting episodes 2 days after EGD with biopsy for suspected celiac disease.

Pleats and pain

What caused fever and foul-smelling watery stools in a young man referred with abdominal pain, epigastric in location and radiating to the back? He had no previous comorbid disease but had taken many courses of antibiotics.

Current Reviews

Validation of magnetic resonance imaging for quantification of intrapancreatic fat deposition using phantom and histologic comparators: a systematic review and meta-analysis

Intrapancreatic fat deposition (IPFD) is defined as the diffuse presence of fat within the pancreas, including intralobular and interlobular fat but excluding extralobular fat [ 1 ]. IPFD has recently been brought to the fore as research into …

Efficacy of Olezarsen in Severe Hypertriglyceridemia and Acute Pancreatitis Risk: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Hypertriglyceridemia is a common lipid disorder that presents significant clinical challenges, having a strong association with cardiovascular disease, pancreatitis, and metabolic syndrome [ 1 , 2 ]. Severe hypertriglyceridemia (SHTG), defined as a …

Simultaneous improvement of immunoglobulin G4–related disease complicated by nontuberculous mycobacteria infection by anti-infective therapy alone: a case-based literature review

Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated disease, and antigenic stimulation by allergen or malignancy is considered a potential pathogenesis. To date, IgG4-RD complicated by acid-fast bacterial infections, such as …

Breaking the Calcium Overload Cycle in Acute Pancreatitis: Emerging Pharmacological Strategies

Acute pancreatitis (AP) is an inflammatory disease of the pancreas that develops as a result of premature activation of pancreatic enzymes and may have diverse etiological factors [ 1 – 3 ]. This condition ranges from a mild, self-limiting form to …

CME & eLearning

Video
SPONSORED

Chronic pancreatitis pain: A multidisciplinary approach and practical solutions

1.5 European CME credits (ECMEC®s)

Severe pain is the most common symptom of chronic pancreatitis. In this live webinar, experts shared the latest insights in pain management for chronic pancreatitis patients. Experts from a range of disciplines discussed pertinent cases and provided practical suggestions for use within clinical practice.

Sponsor:
  • Viatris

Further Reading

Management of Idiopathic Acute Pancreatitis in Europe: An International Pancreas2000 Survey

Acute pancreatitis (AP) is a common gastrointestinal disorder leading to hospital admissions [ 1 ]. Disease course varies from mild abdominal pain to life-threatening multi-organ failure. To be able to prevent relapse, aetiology and the possible …

Immune checkpoint inhibitor-related pancreatitis: a comprehensive review of epidemiology, pathophysiology, and management

Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy but are associated with immune-related adverse events (irAEs) affecting multiple organ systems. ICI-related pancreatitis (ICI-P) is an uncommon but clinically significant …

Autoimmune pancreatitis limited to the main pancreatic duct without mass formation

We present a rare case of autoimmune pancreatitis (AIP) confined exclusively to the subepithelial layer in the main pancreatic duct (MPD) without associated pancreatic enlargement or mass formation. A 73-year-old man presented with elevated serum …

Endoscopically-detected small-intestinal lesions with dense infiltration of IgG4-positive plasma-cells

Immunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory syndrome characterized by dense IgG4-positive plasma-cell infiltrate and progressive fibrosis. Small intestinal involvement is uncommon, and its clinicopathological spectrum …

Image Credits
3d rendering of mitochondria/© wir0man / Getty Images / iStock, Enteral nutrition feeding bag hung on an IV pole/© BlindTurtle / Getty Images / iStock, Combined PET and CT imaging of the pancreas in a patient with pancreatic sarcoidosis/© 2026, Nao Ishidoya et al, Clin J Gastroenterol, under exclusive licence to Japanese Society of Gastroenterology, EGD showing complete obstruction of the duodenal lumen/© (M) 2026, Noemi Zorzetti et al, Dig Dis Sci, Woman with abdominal pain lying on sofa/© Liubomyr Vorona / iStock / Getty Images Plus (symbolic image with model), Man receiving injection/© InsideCreativeHouse / stock.adobe.com (symbolic image with models), 3D render of small interfering RNA/© Love Employee/stock.adobe.com, Pancreatic and peri-pancreatic collections, accordion sign, and lead pipe sign/© 2025, Shivani Chopra et al, Indian J Gastroenterol, Chronic pancreatitis 3D concept image/© Rasi Bhadramani