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Current Cardiology Reports

Molecular Regulation of Cardiac Conduction System Development

  • 11-07-2024
  • Pacemaker
  • Regenerative Medicine (SM Wu, Section Editor)
Published in:
Authors
Lucie Boulgakoff
Gaetano D’Amato
Lucile Miquerol
Published in
Current Cardiology Reports | Issue 9/2024

Abstract

Purpose of review

The cardiac conduction system, composed of pacemaker cells and conducting cardiomyocytes, orchestrates the propagation of electrical activity to synchronize heartbeats. The conduction system plays a crucial role in the development of cardiac arrhythmias. In the embryo, the cells of the conduction system derive from the same cardiac progenitors as the contractile cardiomyocytes and and the key question is how this choice is made during development.

Recent Findings

This review focuses on recent advances in developmental biology using the mouse as animal model to better understand the cellular origin and molecular regulations that control morphogenesis of the cardiac conduction system, including the latest findings in single-cell transcriptomics.

Summary

The conducting cell fate is acquired during development starting with pacemaking activity and last with the formation of a complex fast-conducting network. Cardiac conduction system morphogenesis is controlled by complex transcriptional and gene regulatory networks that differ in the components of the cardiac conduction system.
Title
Molecular Regulation of Cardiac Conduction System Development
Authors
Lucie Boulgakoff
Gaetano D’Amato
Lucile Miquerol
Publication date
11-07-2024
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 9/2024
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-024-02094-7
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This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.
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Image Credits
Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME