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Open Access 01-12-2023 | Overweight | Study protocol

Postprandial effects of dietary protein source on metabolic responses, appetite, and arterial stiffness indices in overweight and obese men: the study protocol for a randomized crossover clinical trial

Authors: Zahra Dehnavi, Ali Jafarzadeh Esfehani, Omolbanin Hajhoseini, Hanieh Barghchi, Aliyeh Ghannadzadeh Yazdi, Zahra Khorasanchi, Mahdi Shadnoush, Reza Rezvani, Habibollah Esmaily, Mohammad Safarian

Published in: Trials | Issue 1/2023

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Abstract

Background

Different dietary protein sources are supposed to have various effects on metabolic responses and arterial stiffness in the postprandial period. This study aims to assess the postprandial effects of dietary protein sources, including animal-based protein (AP) and plant-based protein (PP), as part of a high-protein breakfast on appetite response, energy metabolism, and arterial stiffness in overweight and obese men.

Methods

This acute randomized crossover clinical trial will be conducted at the Persian study research center at Imam Reza Hospital, affiliated with the Mashhad University of Medical Sciences, located in the northeast of Iran. Forty-six healthy overweight, and obese men aged 18–60 years will be enrolled based on the eligibility criteria. The subjects will complete two interventions (high-protein AP and PP meals) with 1 week washout period. The primary outcome will be the acute effect of the two test meals on appetite response, energy metabolism parameters, including resting metabolism rate (RMR), diet-induced thermogenesis (DIT), and substrate oxidation (SO), and arterial stiffness indices, including pulse wave velocity (PWV) and pulse wave analysis (PWA). The secondary outcomes include changes in lipemia, glycemia, and insulinemia.

Discussion

The findings of this study will provide novel insight regarding the acute effects of different protein sources on energy metabolism, appetite, and arterial stiffness as a significant cardiovascular disease (CVD) risk factor. It will help dieticians develop effective and efficient meal plans to improve weight reduction and maintenance in overweight/obese individuals.

Trial registration

Iranian Registry of Clinical Trials; code: IRCT20211230053570N1; registered on February 10, 2022
Appendix
Available only for authorised users
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Metadata
Title
Postprandial effects of dietary protein source on metabolic responses, appetite, and arterial stiffness indices in overweight and obese men: the study protocol for a randomized crossover clinical trial
Authors
Zahra Dehnavi
Ali Jafarzadeh Esfehani
Omolbanin Hajhoseini
Hanieh Barghchi
Aliyeh Ghannadzadeh Yazdi
Zahra Khorasanchi
Mahdi Shadnoush
Reza Rezvani
Habibollah Esmaily
Mohammad Safarian
Publication date
01-12-2023
Publisher
BioMed Central
Keyword
Overweight
Published in
Trials / Issue 1/2023
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/s13063-023-07374-1

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