Harnessing optics and statistics for early detection and prognosis in breast and ovarian cancer

Environmental factors are responsible for 90% of cancers and breast cancer is the most common cancers occurring worldwide. The 18th most frequent cancer is ovarian cancer and sixth most frequent cancer in the world is liver cancer. Why we have chosen this study. Early prognosis and therapeutic development for cancer is the main goal of this manuscript through optics and Pearson correlation tools. Polarimetry is used to quantify biochemical and characterize tissues, especially for cancer prognosis. Four polarimetric parameters total (diattenuation, depolarization and retardance) and orientation that have elevated values for malignant and low values for benign for both breast cancer and ovarian cancers. Most of blood parameters and components show attenuation for both cancers under Cefexime. Size of WBCs fluctuates between6.1-9.2 (µm) for breast cancer and 6.0-8.5 (µm) for ovarian cancer. WBCs show strong correlation with bilirubin total (r = 0.2829, p = 0.000) and creatinine (r = 0.2384, p = 0.000) for breast cancer, RBCs have positive correlation with SGPT (r = 0.1872, p = 0.022) and T. Bilirubin (r = 0.1585, p = 0.000) for breast cancer. Serum creatinine with RBCs (r = 0.113, p = 0.000) and SGPT only with MCV (r = 0.6814, p = 0.000) show very strong positive correlation for liver cancer. Thus polarimetric properties especially retardance and depolarization can be used for early prognosis / diagnose of cancer.