Causal role of ischemic heart disease in ovarian cancer subtypes
- Open Access
- 01-12-2025
- Ovarian Cancer
- Analysis
Published in:
- Authors
- Jianhai Chen
- Huabin He
- Ling Gao
- Published in
- Discover Oncology | Issue 1/2025
Abstract
Background
Ischemic heart disease (IHD) may share biological mechanisms with cancer, including ovarian cancer, through pathways such as chronic inflammation and oxidative stress. However, the relationship between IHD and ovarian cancer subtypes remains unclear. This study used Mendelian randomization (MR) to explore potential causal associations.
Methods
A two-sample MR analysis was conducted using genetic instruments for IHD from large-scale genome-wide association studies (GWAS). The inverse-variance weighted (IVW) method was used as the primary analysis, supported by MR-Egger, weighted median, and MR-PRESSO for sensitivity analyses.
Results
No significant association was found between IHD and overall ovarian cancer risk (OR = 0.97, 95% CI 0.92–1.03, P = 0.378). However, IHD was linked to a reduced risk of endometrioid ovarian cancer (OR = 0.86, 95% CI 0.76–0.98, P = 0.027). No associations were observed for serous, mucinous, or clear cell ovarian cancers. Sensitivity analyses confirmed robust findings.
Conclusions
IHD may confer a protective effect against endometrioid ovarian cancer but does not influence overall ovarian cancer risk. These findings highlight the need for further research into subtype-specific mechanisms.
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- Title
- Causal role of ischemic heart disease in ovarian cancer subtypes
- Authors
-
Jianhai Chen
Huabin He
Ling Gao
- Publication date
- 01-12-2025
- Publisher
- Springer US
- Keywords
-
Ovarian Cancer
Ovarian Cancer - Published in
-
Discover Oncology / Issue 1/2025
Print ISSN: 1868-8497
Electronic ISSN: 2730-6011 - DOI
- https://doi.org/10.1007/s12672-025-01824-9
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