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Published in: Journal of Bone and Mineral Metabolism 5/2020

01-09-2020 | Osteoporosis | Original Article

The old sheep: a convenient and suitable model for senile osteopenia

Authors: Stefan Maenz, Olaf Brinkmann, Ines Hasenbein, Christina Braun, Elke Kunisch, Victoria Horbert, Francesca Gunnella, André Sachse, Sabine Bischoff, Harald Schubert, Klaus D. Jandt, Jörg Bossert, Dominik Driesch, Raimund W. Kinne, Matthias Bungartz

Published in: Journal of Bone and Mineral Metabolism | Issue 5/2020

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Abstract

Introduction

Existing osteoporosis models in sheep exhibit some disadvantages, e.g., challenging surgical procedures, serious ethical concerns, failure of reliable induction of substantial bone loss, or lack of comparability to the human condition. This study aimed to compare bone morphological and mechanical properties of old and young sheep, and to evaluate the suitability of the old sheep as a model for senile osteopenia.

Materials and methods

The lumbar vertebral body L3 of female merino sheep with two age ranges, i.e., old animals (6–10 years; n = 41) and young animals (2–4 years; n = 40), was analyzed concerning its morphological and mechanical properties by bone densitometry, quantitative histomorphometry, and biomechanical testing of the corticalis and/or central spongious region.

Results

In comparison with young sheep, old animals showed only marginally diminished bone mineral density of the vertebral bodies, but significantly decreased structural (bone volume, − 15.1%; ventral cortical thickness, − 11.8%; lateral cortical thickness, − 12.2%) and bone formation parameters (osteoid volume, osteoid surface, osteoid thickness, osteoblast surface, all − 100.0%), as well as significantly increased bone erosion (eroded surface, osteoclast surface). This resulted in numerically decreased biomechanical properties (compressive strength; − 6.4%).

Conclusion

Old sheep may represent a suitable model of senile osteopenia with markedly diminished bone structure and formation, and substantially augmented bone erosion. The underlying physiological aging concept reduces challenging surgical procedures and ethical concerns and, due to complex alteration of different facets of bone turnover, may be well representative of the human condition.
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Metadata
Title
The old sheep: a convenient and suitable model for senile osteopenia
Authors
Stefan Maenz
Olaf Brinkmann
Ines Hasenbein
Christina Braun
Elke Kunisch
Victoria Horbert
Francesca Gunnella
André Sachse
Sabine Bischoff
Harald Schubert
Klaus D. Jandt
Jörg Bossert
Dominik Driesch
Raimund W. Kinne
Matthias Bungartz
Publication date
01-09-2020
Publisher
Springer Singapore
Published in
Journal of Bone and Mineral Metabolism / Issue 5/2020
Print ISSN: 0914-8779
Electronic ISSN: 1435-5604
DOI
https://doi.org/10.1007/s00774-020-01098-x

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Journal of Bone and Mineral Metabolism 5/2020 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
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Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

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Mastering chronic pancreatitis pain: A multidisciplinary approach and practical solutions

Severe pain is the most common symptom of chronic pancreatitis. In this webinar, experts share the latest insights in pain management for chronic pancreatitis patients. Experts from a range of disciplines discuss pertinent cases and provide practical suggestions for use within clinical practice.

Sponsored by: Viatris

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