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Published in: Journal of Bone and Mineral Metabolism 3/2024

25-04-2024 | Osteoporosis | Original Article

TBS correlates with bone density and microstructure at trabecular and cortical bone evaluated by HR-pQCT

Authors: E. M. F. Gama, L. M. C. Mendonça, F. P. Paranhos-Neto, L. Vieira Neto, M. Madeira, M. L. F. Farias

Published in: Journal of Bone and Mineral Metabolism | Issue 3/2024

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Abstract

Introduction

Trabecular bone score (TBS) estimates bone microstructure, which is directly measured by high-resolution peripheral quantitative computed tomography (HRpQCT). We evaluated the correlation between these methods and TBS influence on fracture risk assessed by FRAX.

Materials and methods

We evaluated 129 individuals (82 women, 43 postmenopausal) 20 to 82.3 years without prevalent clinical or non-clinical morphometric vertebral fractures, using DXA (spine and hip), HR-pQCT at distal radius (R) and tibia (T) and TBS which classifies bone microarchitecture as normal (TBS ≥ 1.350), partially degraded (1.200 < TBS < 1.350), or degraded (TBS ≤ 1.200).

Results

Spine and hip BMD and HR-pQCT parameters at cortical bone: area (T), density (R,T) thickness (T) and trabecular bone: density (R,T), number (T) and thickness (R) were significantly better in the 78 individuals with normal TBS (group 1) versus the 51 classified as partially degraded (n = 42) or degraded microarchitecture (n = 9) altogether (group 2). TBS values correlated with age (r = − 0.55), positively with spine and hip BMD and all cortical and trabecular bone density and microstructure parameters evaluated, p < 0.05 all tests. Binary logistic regression defined age (p = 0.008) and cortical thickness (p = 0.018) as main influences on TBS, while ANCOVA demonstrated that HR-pQCT data corrected for age were not different between TBS groups 1 and 2. TBS adjustment increased FRAX risk for major osteoporotic fractures and hip fractures.

Conclusion

We describe significant association between TBS and both trabecular and cortical bone parameters measured by HR-pQCT, consistent with TBS influence on fracture risk estimation by FRAX, including hip fractures, where cortical bone predominates.
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Metadata
Title
TBS correlates with bone density and microstructure at trabecular and cortical bone evaluated by HR-pQCT
Authors
E. M. F. Gama
L. M. C. Mendonça
F. P. Paranhos-Neto
L. Vieira Neto
M. Madeira
M. L. F. Farias
Publication date
25-04-2024
Publisher
Springer Nature Singapore
Published in
Journal of Bone and Mineral Metabolism / Issue 3/2024
Print ISSN: 0914-8779
Electronic ISSN: 1435-5604
DOI
https://doi.org/10.1007/s00774-024-01508-4

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